4,721 research outputs found
Psychology of Reflexivity and reflexivity for psychology
No full textA long tradition has produced a misleading interpretation of the categories
of idiographic and nomothetic. Such an interpretation has hindered
the development of psychology and more in general of social science. “Idiographic”
has been treated as a matter of identity, an ideological approach
that continues to be reproduced through the conflict with what-is-outside-it
viii S. Salvatore, G. Marsico, and R. Andrisano-Ruggieri
(i.e., nomothetic mainstream psychology). Far from such a militant ritualization
of the concept, YIS aims at promoting a return to the origin of
what Windelband (1904/1998) proposed, namely the idea of idiographic
and nomothetic as categories depicting two complementary—rather than
alternative - forms of knowledge building
Palliative treatment: selective arterial embolisation for bone metastases.
No full textTreatment options in patients with bone metastases are mostly aimed at palliation. The goals of treatment in these patients are pain control, prevention and treatment of fractures, maintenance of independence and prevention of tumor progression, and improvement of quality of remaining life [1,2]. Traditional palliative treatments include surgery, if the metastatic lesion is accessible, and/or external beam radiation therapy [3,4]. However, all metastatic lesions are progressive, causing bone failure by producing angiogenic and bone-reabsorbing factors [4]. In addition, most, if not all metastatic lesions are hypervascular. Some lesions such as renal and thyroid metastases are highly hypervascular [5–7]. This may cause technical difficulties with respect to the extent of surgery and primary stability for pain relief [2,8,9]
Constantinopoli vista da P. Giulo Mancinelli S. J. (1583-1585)
No full textREB 60 2002 France p. 113-131
Vincenzo Ruggieri, Constantinopoli vista da P. Giulo Mancinelli S. J. (1583-1585). — The chief of the first Jesuit mission to Constantinople in the 1580's, P. Giulio Mancinelli, is the author of a report of the mission. Preserved in the General Archives of the Jesuit Order (Rome), this document also contains a contemporary description of Constantinople. The article presents an edition and commentary on this topographical part of Mancinelli' s report.La première mission jésuite à Constantinople, effectuée dans les années 1580, a eu pour chef P. Giulio Mancinelli, qui a laissé un rapport de cette mission. Conservé dans les Archives Générales de la Compagnie de Jésus (Rome), ce document comprend également une description contemporaine de Constantinople. C'est cette partie, topographique, qui est éditée et commentée dans l'article.Ruggieri Vincenzo. Constantinopoli vista da P. Giulo Mancinelli S. J. (1583-1585). In: Revue des études byzantines, tome 60, 2002. pp. 113-131
Spectrum of skeletal abnormalities in a complex malformation syndrome with "cutis tricolor" (Ruggieri-Happle syndrome)
No full textBackground: The term cutis tricolor describes the combination of congenital hyper- and hypopigmented skin lesions in close proximity to each other in a background of normal complexion. This phenomenon has been reported: (i) as a purely cutaneous trait; (ii) as a part of a complex malformation syndrome (Ruggieri-Happle syndrome - RHS); (iii) as a distinct type [cutis tricolor parvimaculata]; (iv) in association with other (e.g. vascular) skin disturbances. Objectives: To delineate the spectrum of skeletal defects in cutis tricolor. Methods: Retrospective and prospective analysis of skeletal surveys in 14 subjects (eight men; six women; aged 2-28 years) with cutis tricolor [4 purely cutaneous trait; 10 syndromic (RHS)]. Results: Bone abnormalities were recorded in 71.4% (10/14) of patients [100% (10/10) of cases with (other-than-skeletal) extra-cutaneous manifestations vs. null (0/4) in cases with purely cutaneous traits] and included overall small skull (n = 6); prognathism (n = 6); 'J'-shaped pituitary fossa (n = 1); absence of atlas posterior arch (n = 3); frontal bossing (n = 6); scoliosis (n = 9) with kyphosis (n = 6) and/or lordosis (n = 6); vertebral (n = 9) and ribs (n = 4) defects. Negative ZFHX1B gene analyses excluded overlaps with Mowat-Wilson syndrome. Conclusions: Cutis tricolor may be a marker of underlying skeletal involvement particularly in subjects with a complex syndromic (RHS) phenotype. © 2010 The Author(s)/Acta Pædiatrica © 2010 Foundation Acta Pædiatrica
Surgical treatment for metastatic pathological fractures.
No full textPathological fractures of the long bones occur in 10–29% of patients with bone metastases. The occurrence of these fractures may alter management and prognosis, decrease quality of life and jeopardize survival [1–4]. The fracture hematoma may contaminate the adjacent soft tissue, nerves, vessels and joint, and damage to the microcirculation may favor distant hematogenous dissemination of the tumor [5]
Surgical treatment for pelvic bone metastases.
No full textThe pelvis is the second most common site of bone metastases after the spine. Pain, bone destruction causing mechanical instability and pathological fractures are the most common manifestations. Traditional treatments for pelvic bone metastases include surgery and external beam radiation therapy. If bone destruction is limited, analgesics, radiation therapy, hormonal therapy, chemotherapy, embolization, bisphosphonates and minimally invasive techniques such as radiofrequency ablation, osteoplasty and cryosurgery can be considered [6]. Lesions of the hemipelvis not directly involving the hip joint, pathological fractures sustained through an area of the pelvis other than the acetabulum and avulsion fractures of the anterior superior/inferior iliac spines, iliac crest and pubic rami seldom require surgical stabilization and reconstruction because pelvic stability is maintained. By contrast, diffuse involvement of the pelvis, impending or existing pelvic discontinuity and bony destruction of the periacetabular area warrants surgical treatment [4,7–10]. The use of poly(methyl methacrylate) to bridge large defects and suspend an acetabular component, conventional total hip replacement, massive allograft or saddle megaprosthetic reconstruction are likely to fail because of the deficient bone and the progressive osteolytic disease [1]
LICEO FARNESINA. Nuovi spazi didattici.
No full textIl contributo riguarda la presentazione/illustrazione del Progetto di RDM Studio (PV. Dell'Aira, P. Misino, M. Ruggieri, P. Troiano) al Concorso Internazionale "Liceo Farnesina".
L’obiettivo principale contenuto nel Bando Concorsuale, riguardava la fattibilità in 2 fasi, dovuta a specifiche necessità finanziarie. Il progetto trae la sua organizzazione morfologica da tale requisito, conformando il plesso scolastico come edificio "bino", attraverso due volumetrie tra loro interconnesse, strutturalmente indipendenti e realizzabili in successione consentendo un'eventuale cantierizzazione "in esercizio".The contribution concerns the presentation / illustration of the Project of RDM Studio (PV. Dell'Aira, P. Misino, M. Ruggieri, P. Troiano) at the International Competition "Liceo Farnesina".
The main objective contained in the Call for Proposals was the two-stage feasibility, due to specific financial needs. The project draws its morphological organization from that requirement by conforming the school plexus to a "bino" building, through two interconnected volumes, structurally independent and executable in succession, allowing a possible "operational" construction
Thymosin beta arg10, a major variant of thymosin beta 10 in rabbit tissues.
No full textTwo homologous peptides, designated thymosin beta 4 and thymosin beta 10, respectively, have been shown to be widely distributed in mammalian cells and tissues (S. Erickson-Viitanen, S. Ruggieri, P. Natalini, and B.L. Horecker (1983) Arch. Biochem. Biophys. 221, 570-576; S. Erickson-Viitanen, S. Ruggieri, P. Natalini, and B.L. Horecker, (1983) Arch. Biochem. Biophys. 225, 407-413). In the rabbit, thymosin beta 4 is replaced by a variant, thymosin beta ala4, that contains alanine in place of serine at the blocked NH2-terminus. It is reported that in rabbit tissues thymosin beta 10 is also replaced by a variant, designated thymosin beta arg10, that contains an additional amino acid, arginine, inserted following lysine-38. The rabbit tissues analyzed also differ from those of other mammals in the relative quantities of thymosin beta ala4 and beta arg10, which are nearly equal, compared to tissues from other mammals where the quantities of thymosin beta 10 are only one-third to one-tenth those of thymosin beta 4
Palliative treatments: electrochemotherapy and thermoablation.
No full textMetastatic disease is a major cause of pain and decreased quality of life in patients with cancer. Autopsy studies have shown that up to 85% of patients who die from breast, prostate or lung cancer have histological evidence of bone metastases at the time of death. In Europe, the number of new cases of bone metastases per year is approximately 1 in 100,000. Worsening of patients’ quality of life is due to associated symptoms such as intractable pain, pathological fractures, spinal cord compression, hypercalcemia and reduction of movement and performance status
Metastatic spread to bone: The role of chemotherapy
No full textCancer metastasis includes tumor cell intravasation, transport and immune evasion within the circulatory system, arrest at a secondary site, extravasation and finally, colonization and growth [1]. However, cancer metastasis remains poorly understood in terms of clinical outcome, pathology and tissue specificity of different tumor types. The predilection of some cancers to target and proliferate in bone is also unclear (Figure 2.1). Less than 1% of cancer cells entering the blood circulation successfully generate metastatic foci [2]. Consequently, there are few successful treatments that directly target metastatic cancer; identifying effective therapeutic targets for this stage of cancer and prognostic factors to identify those patients prone to develop local and distant progressive disease is challenging [2].Genetic profiling of tumors has revealed important regulators of the metastatic process and suggested novel targets for cancer therapeutics. Targeting the tumor cell alone is not sufficient; multimodality therapy against tumor cells, their growth factors and the essential accessory cells with which cancer cells interact is imperative. In the bone marrow and within the tumor stroma, two niches constitute highly specific, physiologically defined sites; the vascular and stromal niche. A high preponderance of tumor cells is found in the bone marrow of patients with malignancy, even in the absence of overt distant metastases. Bisphosphonates inhibit normal and pathologic osteoclast-mediated bone resorption. Denosumab inhibits the maturation of osteoclasts by binding to RANKL, protecting the bone from degradation
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