263 research outputs found
Association between atherogenic index of plasma and carotid intima-media thickness in a cohort of Mediterranean women
No full textThe association between early atherosclerosis (IMT) and Atherogenic index of plasma (AIP), a marker of atherogenicity (log triglycerides/HDL Cholesterol) was evaluated in a population-based cohort study in women, aged 30-69, living in the metropolitan area of Naples, Southern Italy (Progetto ATENA). Serum cholesterol, HDL-cholesterol, LDL-cholesterol, Triglyceride, Insulin, HOMA, Apo B, hs-CPR were measured in 390 menopausal women, as a part of 5.062 participants of the cohort. Women in the second and third tertile of AIP showed an increased common carotid intima-media thickness compared with those in the first tertile: II vs I tertile (O.R. = 2.24, p = 0.007), III vs I tertile (O.R. = 2.29, p = 0.005), adjusted for age and Systolic pressure or II vs I tertile (O.R. = 2.19, p = 0.014), III vs I tertile (O.R. = 2.13, p = 0.026), adjusted for age, Systolic pressure, Body mass index and Apo B. Women in the second and third tertile of AIP compared to those in the first tertile, showed an OR of 2.14 (p = 0.016) and 1.99 (p = 0.033) respectively, of having elevates level of IMT, adjusted for traditional cardiovascular risk factor (age, Systolic Pressure, BMI, LDL Cholesterol, Diabetes diagnosis). This finding shows that in this group of menopausal women increased IMT is associated with elevated AIP independently of age and different cardiovascular risk factors. These results are in line with the hypothesis that AIP may be an useful clinical tools to give additional information in the risk assessment for atherosclerotic disease, in particular in postmenopausal women
Obesity, overweight, and weight gain over adult life are main determinants of elevated hs-CRP in a cohort of Mediterranean women.
No full textARTERIAL HYPERTENSION AND CARDIOVASCULAR PROGNOSIS AFTER SUCCESSFUL REPAIR OF AORTIC COARCTATION: A CLINICAL MODEL FOR THE STUDY OF VASCULAR FUNCTION
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The peripheral circulation in the hypertensive patients: effects of antihypertensive drugs
No full textThe peripheral circulation in the hypertensive patients: effects of antihypertensive drugs
No full textLaboratorio di epidemiologia in un master per medici di medicina generale : valore e significato dei dati sull' attività fisica.
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Insulin resistance and impaired glucose tolerance in obese children and adolescents from southern Italy
No full textBackground and aim: Obesity in children may lead to insulin resistance and impaired glucose regulation over time. The aim of this study was to investigate the insulin resistance status and the frequency of impaired glucose regulation in obese children and adolescents from the Campania region (Southern Italy), where the prevalence of obesity is among the highest in Europe.
Methods and results: We studied 100 (62 mate) Italian obese children and adolescents (mean age 10.1 +/- 2.7 years) and 50 (27 mate) normal weight healthy subjects (mean age 10.2 +/- 2.7 years). Anthropometric measures and biochemical tests were performed in all subjects. In obese patients an oral glucose tolerance test was also performed. The estimate of insulin resistance was calculated by a homeostasis model. assessment (HOMA) index. A cut-off HOMA level of > 2.5 in children and > 4.0 in adolescents was used to identify an insulin-resistance status. Insulin resistance was found in 40.8% of obese children and 41.2% of obese adolescents, whereas it was found in 3.0% of normal children and none of the 17 normal adolescents (p < 0.0001 and p < 0.002, respectively). None of the subjects had impaired fasting glucose or diabetes, white 4 obese patients had impaired glucose tolerance (4%).
Conclusions: Impaired glucose tolerance is still rare whereas insulin-resistance is already detectable in more than 40% of obese children and adolescents in Southern Italy. Our observations confirm that metabolic risk factors can be found at a very early age and strengthen the case for implementing programmes for prevention and treatment of childhood obesity
Role of Polyunsaturated Omega-3 Fatty Acids and Micronutrient Intake on Atherosclerosis and Cardiovascular Disease
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