393 research outputs found
Cyanolipid-rich seed oils from Allophylus natalensis and A. dregeanus
No full textAs a continuation of our study on plants of the Sapindaceae, the chemical composition of the oil extracted from seeds of Allophylus natalensis (Sonder) De Winter and of A. dregeanus (Sonder) De Winter has been investigated. The oil from both species contained approximately equal amounts of TAG and type I cyanolipids (CL), 1-cyano-2-hydroxymethylprop-2-en-1-ol-diesters, with minor amounts of type III CL, 1-cyano-2-hydroxymethylprop-2-en-1-ol-diesters. Structural investigation of the oil components was accomplished by chemical, chromatographic (TLC, CC, GC, and GC-MS), and spectroscopic (IR, NMR) means. GC and GC-MS analysis showed that C-20 FA were dominant in the CL components of the oil from the two species (44-80% vs. 21-26% in TAG), with cis-11-eicosenoic acid (36-46%) and cis 13-eicosenoic acid (paullinic acid, 23-37%) as the major esterified fatty acyl chains in A. natalensis and A. dregeanus, respectively. cis-Vaccenic acid was particularly abundant (11-31%) in the CL from A. dregeanus, whereas eicosanoic acid (10-22%) was also a major component of CL in both species
Sarcomatous variant of Wilms' tumor. A light and immunohistochemical study of four cases
No full textFour cases of infantile sarcomatous renal tumors are reported. Rhabdomyoblastic differentiation was investigated in these tumors by the immunoperoxidase method using antimyoglobin sera. Rhabdomyoblastic cells were found in 2 cases and in a metastasis of one case in which the primary tumor was composed of undifferentiated cells negative for myoglobin stain. The histogenesis of these neoplasias is discussed, and it is suggested that they are a sarcomatous variant of Wilms' tumor
Characterization of seed oil components from Nephelium lappaceum L.
No full textThe chem. compn. of the oil extd. from the seeds of Nephelium lappaceum L., commonly known as rambutan, has been investigated. The oil from this plant, similar to other members of the Sapindaceae, typically contained triglycerides (83%) and cyanolipids (17%). The latter consisted of type III cyanolipids, 1-cyano-2-hydroxymethylprop-1-en-3-ol diesters. Structural investigation of the oil components was carried out using chem., chromatog. and spectroscopic methods. Oleic and arachidic acids were the two dominant esterified fatty acyl chains in both triglycerides and cyanolipids. Eicosenoic acids (cis-vaccenic and paullinic acid) were present in higher amts. in the cyanolipid fraction of the oil
Characterization of seed oil components from Nephelium lappaceum L
No full textThe chemical composition of the oil extracted from the seeds of Nephelium lappaceum L., commonly known as rambutan, has been investigated. The oil from this plant, similar to other members of the Sapindaceae, typically contained triglycerides (83%) and cyanolipids (17%). The latter consisted of type III cyanolipids, 1-cyano-2-hydroxymethylprop-1-en-3-ol diesters. Structural investigation of the oil components was carried out using chemical, chromatographic and spectroscopic methods. Oleic and arachidic acids were the two dominant esterified fatty acyl chains in both triglycerides and cyanolipids. Eicosenoic acids (cis-vaccenic and paullinic acid) were present in higher amounts in the cyanolipid fraction of the oil
Exploring the use of dimethyl fumarate as microglia modulator for neurodegenerative diseases treatment
No full textThe maintenance of redox homeostasis in the brain is critical for the prevention of the development of neurodegenerative diseases. Drugs acting on brain redox balance can be promising for the treatment of neurodegeneration. For more than four decades, dimethyl fumarate (DMF) and other derivatives of fumaric acid ester compounds have been shown to mitigate a number of pathological mechanisms associated with psoriasis and relapsing forms of multiple sclerosis (MS). Recently, DMF has been shown to exert a neuroprotective effect on the central nervous system (CNS), possibly through the modulation of microglia detrimental actions, observed also in multiple brain injuries. In addition to the hypothesis that DMF is linked to the activation of NRF2 and NF-kB transcription factors, the neuroprotective action of DMF may be mediated by the activation of the glutathione (GSH) antioxidant pathway and the regulation of brain iron homeostasis. This review will focus on the role of DMF as an antioxidant modulator in microglia processes and on its mechanisms of action in the modulation of different pathways to attenuate neurodegenerative disease progression
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