230 research outputs found
Gli avverbi monolessicali di luogo, tempo e maniera nelle lingue indoeuropee antiche. Verso un approccio tipologico
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Articles and Quantifiers in the Mediterranean Languages: a Typological-Diachronic Analysis
No full textLe vicende storiche della sede dell’Accademia di San Luca al Foro di Cesare
No full textLa breve vita dell’incompiuto palazzo dell’Accademia di S. Luca, la cui costruzione venne iniziata nel 1931, è indissolubilmente legata alla lunga storia del Foro di Cesare, sulle cui spoglie si erge, e della chiesa dei Ss. Luca e Martina, sul retro della quale sorse la prima sede storica dell’Accademia realizzata al tempo di papa Urbano VIII (1635-44).
Il nuovo palazzo dell’Accademia dei pittori del quale ancora si conservano le fondazioni riportate alla luce negli scavi condotti dalla Sovraintendenza Comunale di Roma negli anni 1998-2000, doveva infatti essere eretto sul medesimo sito occupato dalla precedente sede. L’importanza dell’edificio è legata, oltre che alla sua prestigiosa ubicazione, anche agli illustri progettisti che furono personalità di spicco del panorama culturale del periodo a cavallo tra gli anni Venti e Trenta dello scorso secolo. I resti del palazzo e i progetti di seguito analizzati sono infatti una eloquente testimonianza tanto dei nuovi fermenti intellettuali quanto delle criticità dell’epoca e palesano pensieri e ripensamenti che furono sottesi alla realizzazione oltre che dell’Accademia stessa anche, e soprattutto, della nascente via dell’Impero.The seat of the ancient, prestigious Academy of San Luca, the leading cultural institution in Roma, was traditionally located by the church of SS. Luca e Martina in the Roman Forum. The first building, which housed the Academy of Painters, was destroyed in 1929-31 when extensive demolitions were carried out in the area, as part of a plan for recovery of the Forum complex. Projects for the new building were submitted by Tullio Passarelli, Gustavo Giovannoni and finally Arnaldo Foschini; after a long debate construction started in 1932, but the project was soon abandoned as the archaeological issue prevailed, and it was decided to excavate the underlying remain of Caesar’s Forum. Passarelli’s and Foschini’s drawings are published here, together with surveys of the present state by the author of the article, and show careful planning in the layout of the interiors, while the exteriors are a remarkable exercise in the academic style, universally adopted in Rome’s official buildings in the Thirties
Le vicende storiche della sede dell’Accademia di San Luca al Foro di Cesare
No full textLa breve vita dell’incompiuto palazzo dell’Accademia di S. Luca, la cui costruzione venne iniziata nel 1931, è indissolubilmente legata alla lunga storia del Foro di Cesare, sulle cui spoglie si erge, e della chiesa dei Ss. Luca e Martina, sul retro della quale sorse la prima sede storica dell’Accademia realizzata al tempo di papa Urbano VIII (1635-44).
Il nuovo palazzo dell’Accademia dei pittori del quale ancora si conservano le fondazioni riportate alla luce negli scavi condotti dalla Sovraintendenza Comunale di Roma negli anni 1998-2000, doveva infatti essere eretto sul medesimo sito occupato dalla precedente sede. L’importanza dell’edificio è legata, oltre che alla sua prestigiosa ubicazione, anche agli illustri progettisti che furono personalità di spicco del panorama culturale del periodo a cavallo tra gli anni Venti e Trenta dello scorso secolo. I resti del palazzo e i progetti di seguito analizzati sono infatti una eloquente testimonianza tanto dei nuovi fermenti intellettuali quanto delle criticità dell’epoca e palesano pensieri e ripensamenti che furono sottesi alla realizzazione oltre che dell’Accademia stessa anche, e soprattutto, della nascente via dell’Impero.The seat of the ancient, prestigious Academy of San Luca, the leading cultural institution in Roma, was traditionally located by the church of SS. Luca e Martina in the Roman Forum. The first building, which housed the Academy of Painters, was destroyed in 1929-31 when extensive demolitions were carried out in the area, as part of a plan for recovery of the Forum complex. Projects for the new building were submitted by Tullio Passarelli, Gustavo Giovannoni and finally Arnaldo Foschini; after a long debate construction started in 1932, but the project was soon abandoned as the archaeological issue prevailed, and it was decided to excavate the underlying remain of Caesar’s Forum. Passarelli’s and Foschini’s drawings are published here, together with surveys of the present state by the author of the article, and show careful planning in the layout of the interiors, while the exteriors are a remarkable exercise in the academic style, universally adopted in Rome’s official buildings in the Thirties
Optimizing the location of helicopter emergency medical service operating sites
No full textThe European Commission Regulation (EU) No 965/2012, now completely operative in all the European countries, allows helicopter night landings for emergency medical service in dedicated spaces, provided with a minimum amount of facilities, called HEMS Operating Sites. This possibility opens new scenarios for the mixed, ambulance/ helicopter, rescue procedure, today not fully exploited. The paper studies the problem of optimal positioning for HEMS sites, where the transfer of the patient from ambulance to helicopter takes place, through the use of Geographic Information System (GIS) and optimization algorithms integrated in the software ArcGIS for Desktop. The optimum is defined in terms of the minimum intervention time. The solution approach has been applied to the area of competence of “SOREU dei Laghi”, in Lombardia region, with a catchment area of almost two million people
Changes in cholesterol metabolism-related gene expression in peripheral blood mononuclear cells from Alzheimer patients
No full textAbstract Background Cholesterol homeostasis dysfunction has been reported to have role in the pathogenesis of Alzheimer disease (AD). Therefore, changes in cholesterol metabolism in blood components may help to develop new potential AD biomarkers. In this study changes in cholesterol metabolism-related gene expression genes were evaluated in peripheral blood mononuclear cells (PBMCs) from AD subjects, their first degree relatives (FDR) and two groups of age matched controls (C1 > 80 years, C2 Results Results showed significantly different behavior (P = 0.000) in the expression of all analyzed genes among the 4 groups. An inverse correlation emerged between the age of controls and the propensity of their PBMCs to express selected genes. Moreover, when gene expression was evaluated in PBMCs from AD patients and compared with that of PBMCs from healthy subjects of the same age, LDL-R and APP mRNAs were most abundant in AD as compared C1 whereas SREBP-2 and particularly nCEH were present at much lower mRNA levels in AD-PBMCs. This study describes for the first time a differential expression profile of cholesterol and APP related genes in PBMCs from AD patients and their FDR. Conclusions We suggest that the expressions of cholesterol homeostasis and APP processing related genes in PBMC could be proposed as possible biomarkers to evaluate AD risk. In addition, gene expression in PBMC could be also used for diagnosis and development of therapeutic strategies as well as for personalized prediction in clinical outcome of AD.</p
Elderly subjects with type 2 diabetes show altered tissue electrical properties
No full textObjective: The aim of the present research was to show the characteristics of body composition in a sample of elderly subjects with type 2 diabetes compared with healthy controls matched by age and body mass index (BMI) by bioelectrical impedance vector analysis. Methods: The sample consisted of 144 free-living patients (84 women and 60 men) with type 2 diabetes 60 to 84 y old and 209 age-matched controls (116 women and 93 men). Anthropometric measurements (weight; height; upper arm, hip, waist, and calf circumferences; biceps; triceps; and subscapular and suprailiac skinfolds) were taken. Blood samples for the assessment of plasma glucose and glycated hemoglobin were collected. The BMI, upper arm muscular area, and waist-to-hip ratio were calculated. Bioelectrical impedance vector analysis was applied. The analysis was performed in the entire diabetic sample and the healthy BMI-matched groups. Results: Compared with healthy subjects, patients had greater weight (P < 0.01 in women), higher BMI (P < 0.01 in women), smaller muscular area (P < 0.01 in men), and thicker skinfolds (P < 0.01 in women and men). Female and male patients showed larger phase angles (P < 0.01). Moreover, female patients showed a shorter vector length and lower resistance (P < 0.01) and male patients showed a higher reactance (P < 0.01). The BMI-matched analysis confirmed that patients were characterized by larger phase angles. Conclusions: Older patients with type 2 diabetes were characterized by peculiar anthropometric and bioelectrical patterns, which can be related to their smaller appendicular muscular area and lower extracellular/intracellular water ratio
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