1,323 research outputs found
Su diritti umani e bioetica in un recente volume di Vittorio Possenti: appunti sociologici
No full textPrendendo spunto da un interessante volume di Vittorio Possenti che mette in guardia dal considerare come diritti umani quelle che spesso sono solo rivendicazioni indebite, l'articolo discute le pagine in cui il filosofo italiano critica vigorosamente il "diritto al figlio" in relazione alla fecondazione artificiale (eterologa) e cerca, al contrario, di argomentare che un "diritto a procreare artificialmente" è configurabile nella prospettiva della sociologia dei diritti umani. Tuttavia, se si vuole evitare lo scivolamento verso un'etica libertaria e l'eugenetica paventato da Possenti, questo diritto deve essere configurato come "relativo", cioè condizionato e legato ai diritti concorrenti del nascituro e alla funzione terapeutica della fecondazione artificiale
Cultura dei diritti e lavoro della memoria
No full textDiscussione di P. P. Portinaro, "I conti con il passato
Climate change in a critical planetary perspective: Dipesh Chakrabarty and the Anthropocene vs. Capitalocene controversy
No full textThe essay traces Dipesh Chakrabarty’s reflections on the Anthropocene, the epoch of “anthropogenic” climate change, to discuss them in light of the critiques developed in ecomarxist circles, particularly by Jason W. Moore, Andreas Malm, and Alf Hornborg. Chakrabarty, a well-known exponent of postcolonial studies and keen critic of globalization processes, points out that the “globe” of “globalization” is not the same “globe” of “global warming,” but rather “the planet” – the Earth-system – with its many forms of life. A complex trajectory of deliberation leads the author to question the “geological agency” of human beings and, ultimately, argue that the climate crisis can be better understood and addressed from a “planetary perspective" (rather than a humanocentric one) capable of placing “life in general” at the center of discussion. In their critiques of the Anthropocene narrative, Moore, Malm, and Hornborg speak instead of a “Capitalocene.” Through comparison with this critical stance, the essay highlights and discusses some of the theoretical premises underpinning Chakrabarty’s thinking so as to advance the hypothesis of a critical planetary perspective. Such a perspective recognizes capitalism as an ecological regime and climate change as a political challenge in which the problem of human domination over the rest of nature is clearly intertwined with the problem of domination and privilege in interhuman relations
Reproductive biology of females of Plesionika edwardsii (Brant , 1851) (Crustacea, decapoda, Pandalidae) in the northern Tyrrhenian sea (Western Mediterranean)
No full textLa crisi climatica tra filosofia e politica
No full textIl testo affronta il tema del clima come problema filosofico-politico discutendo criticamente, in particolare, la riflessione sulla sfida del cambiamento climatico svolta da Dipesh Chakrabarty
Substance P activates ADAM9 mRNA expression and induces α-secretase-mediated amyloid precursor protein cleavage
No full textAltered levels of Substance P (SP), a neuropeptide endowed with neuroprotective and anti-apoptotic properties, were found in brain areas and spinal fluid of Alzheimer's disease (AD) patients. One of the hallmarks of AD is the abnormal extracellular deposition of neurotoxic beta amyloid (Aβ) peptides, derived from the proteolytic processing of amyloid precursor protein (APP). In the present study, we confirmed, the neurotrophic action of SP in cultured rat cerebellar granule cells (CGCs) and investigated its effects on APP metabolism. Incubation with low (5 mM) potassium induced apoptotic cell death of CGCs and amyloidogenic processing of APP, whereas treatment with SP (200 nM) reverted these effects via NK1 receptors. The non-amyloidogenic effect of SP consisted of reduction of Aβ(1-42), increase of sAPPα and enhanced α-secretase activity, without a significant change in steady-state levels of cellular APP. The intracellular mechanisms whereby SP alters APP metabolism were further investigated by measuring mRNA and/or steady-state protein levels of key enzymes involved with α-, β- and γ-secretase activity. Among them, Adam9, both at the mRNA and protein level, was the only enzyme to be significantly down-regulated following the induction of apoptosis (K5) and up-regulated after SP treatment. In addition to its neuroprotective properties, this study shows that SP is able to stimulate non-amyloidogenic APP processing, thereby reducing the possibility of generation of toxic Aβ peptides in brain
Possenti (Vittorio) éd Maritain e Marx. La critica del marxismo in Maritain
No full textPoulat Emile. Possenti (Vittorio) éd Maritain e Marx. La critica del marxismo in Maritain. In: Archives de sciences sociales des religions, n°46/2, 1978. p. 292
Activation of kinase phosphorylation by heat-shift and mild heat-shock
No full textMost cells activate intracellular signalling to recover from heat damage. An increase of temperature, known as HS (heat shock), induces two major signalling events: the transcriptional induction of HSPs (heat-shock proteins) and the activation of the MAPK (mitogen-activated protein kinase) cascade. We performed the present study to examine the effects of HS, induced by different experimental conditions, on various kinases [ERK (extracellular-signal-regulated kinase), JNK (c-Jun N-terminal kinase), p38, Akt, AMPK (AMP-activated protein kinase) and PKC (protein kinase C)]. We investigated by Western blot analysis the phosphorylation of MAPK as a measure of cellular responsiveness to heat shift (37°C) and mild HS (40°C) in different cell lines. The results of the study indicate that every cell line responded to heat shift, and to a greater extent to HS, increasing ERK and JNK phosphorylation, whereas variable effects on activation or inhibition of PKC, AMPK, Akt and p38 were observed. Besides the implications of intracellular signalling activated by heat variations, these data may be of technical relevance, indicating possible sources of error due to different experimental temperature conditions
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