113 research outputs found
AAN882870 Research Data - Supplemental material for Adult tetralogy repair: factors affecting early outcome in the current era
No full textSupplemental material, AAN882870 Research Data for Adult tetralogy repair: factors affecting early outcome in the current era by Sowmya Ramanan, Navaneetha Sasikumar, Krishna Manohar, Salla Sweta Ramani, RaghavanNair Suresh Kumar , Ravi Agarwal, Raghavan Subramanyam and Kotturathu Mammen Cherian in Asian Cardiovascular and Thoracic Annals</p
Experimental Enhancement of Heat Transfer Analysis on Heat Pipe using SiO2 and TiO2 Nano Fluid
No full textThis paper describes the enhancement of thermal performance of heat pipe using SiO2 and TiO2 nano fliuds. The experimentation explains about the effects of heat pipe inclination and heat input on the thermal efficiency and thermal resistance. Heat pipe is an advance type of heat exchanger which transfers huge amount of heat due to the effect of capillary action and phase change heat transfer principle. Recent developments in the heat pipe with high thermal conductivity through nano fluids. This paper reviews, influence of various factors such as heat pipe tilt angle, charged amount of working fluid, nanoparticles type, size, mass volume fraction and its effect on the improvement of thermal efficiency, heat transfer capacity and reduction in thermal resistance. The nano fluid preparation and the analysis of its thermal characteristics also have been reviewed. Arunkumar. G | Dr. P. Navaneetha Krishnan | Dr. T. Senthil Kumar "Experimental Enhancement of Heat Transfer Analysis on Heat Pipe using SiO2 and TiO2 Nano Fluid" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-4 , June 2018, URL: https://www.ijtsrd.com/papers/ijtsrd13094.pd
A STUDY ON SERVICE QUALITY WITH REFERENCE TO VK HONDA
No full text<p>A service is something that the public needs, such as transport, communications facilities, hospitals, or energy supplies, which are provided in a planned and organized way by the government or an official body.</p>
An immersed boundary method based on domain decomposition
No full textA novel immersed boundary method based on a domain decomposition approach is proposed in the context of a finite element discretisation method. It is applicable to incompressible flows past rigid, deforming, or moving bodies. In this method, unlike most immersed boundary methods, strong boundary conditions are imposed in the regions of the computational domain that are occupied by the structure. In order to achieve this, the proposed formulation decomposes the computational domain by splitting the finite element test functions into solid and fluid parts. In the continuous Galerkin formulation, this produces a smeared representation of the fluid-structure interface. The absence of an immersed boundary forcing term implies that the method itself has no influence on the CFL stability criterion. Furthermore, the stiffness matrix in the momentum equation is sparser than compared with other forcing immersed boundary methods, and symmetry and positive-definiteness of the Laplacian operator in the pressure equation is preserved. As shown in this paper, stability and accurate imposition of boundary conditions make the method promising for high Reynolds number flows. The method is applied to the simulations of two-dimensional laminar flow over stationary and moving cylinders, as well as a moderately high Reynolds number flow past an aerofoil. Good results are obtained when compared with those from previous experimental and numerical studies.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Wind Energ
A study on development of indigenous integrated microwave-ultraviolet reactor for degradation of <i style="mso-bidi-font-style:normal">p</i>-cresol in aqueous solution
No full text458-462An integrated microwave-ultraviolet
(MW-UV) reactor has been developed indigenously and used for the degradation of
aqueous p-cresol. The p-cresol degradation is
carried out in six phases, namely (i) microwave irradiation (MW),
(ii) photodegradation with UV light (UV), (iii) simultaneous microwave and
ultraviolet radiations (MW-UV), (iv) microwave in presence of TiO2
(MW-TiO2), (v) photodegradation by UV and TiO2 (UV-TiO2),
and (vi) simultaneous MW and UV irradiations in presence of TiO2
(MW-UV-TiO2). T<span style="mso-bidi-language:
TA" lang="EN-GB">he order of the degradation efficiency is found to be
MW-UV-TiO2>UV-TiO2>MW-TiO2>UV-MW>UV>MW.
The complete degradation of p-cresol is
obtained by
MW-UV-TiO2 and it is three-fold economical
in catalyst requirement than UV-TiO2. The degradation of p-cresol followed pseudo first order
reaction and the reaction rate (k) for MW-UV-TiO2 is found to be 3
times greater than that for UV-TiO2. The MW-UV-TiO2 is also
2.3 times efficient in the removal of total organic carbon than UV-TiO2.
It is also observed that the unit operating cost of conventional UV-TiO2
and MW-UV-TiO2 is almost same.
</span
Role of cyclin-dependent kinase 5 (Cdk5) in mitochondrial permeability transition pore (mPTP) opening and intracellular Ca2+ dynamics
No full textCyclin-dependent kinase 5 (Cdk5), which plays a role in the development and progression of many human cancers, localizes in the mitochondria, a key determinant of apoptotic cell death. Cdk5 is upregulated in breast cancer cells and Cdk5 loss increases cancer cell sensitivity to chemotherapeutic drugs. However, the molecular mechanism by which Cdk5 loss promotes cell death remains unclear. I hypothesized that Cdk5 loss activates the intrinsic apoptotic pathway in breast cancer cells. I demonstrated that Cdk5-deficient breast cancer cells exhibit increased mitochondrial depolarization, mitochondrial reactive oxygen species (mtROS) levels, and mitochondrial fragmentation that is associated with an increase in both intracellular Ca2+ level and calcineurin activity, and dynamin related protein 1 (DRP1) Ser637 dephosphorylation. To define mitochondria-mediated apoptotic pathway, I utilized various inhibitors of mitochondrial function. Apoptosis is completely prevented by mitochondrial permeability transition pore (mPTP) inhibition, almost fully inhibited by blocking ROS and unaffected by inhibition of mitochondrial fission, suggesting that apoptosis in breast cancer cells due to Cdk5 loss occurs via a novel mPTP-dependent mechanism that acts primarily through ROS increase. Since calcium is the major regulator of mPTP opening, I hypothesized that Cdk5 regulates intracellular calcium homeostasis. Using primary mouse embryonic fibroblasts (MEFs) isolated from Cdk5?/? mouse embryos, I showed that loss of Cdk5 increases inositol 1,4,5-trisphosphate receptor (IP3R)-mediated Ca2+ release from internal stores. Cdk5 associates with and phosphorylates the IP3R1 Ca2+ channel at Ser421 and such phosphorylation controls IP3R1-mediated Ca2+ release as loss of Cdk5, and thus loss of IP3R1 Ser421 phosphorylation, triggers an increase in IP3R1-mediated Ca2+ release in Cdk5?/? MEFs. Analysis of subcellular fractions of MEFs demonstrates that Cdk5 localizes in the mitochondria-associated endoplasmic reticulum membrane (MAM) and Cdk5 loss causes increased ER-mitochondria tethering, a process required for Ca2+ transfer from the ER to the mitochondria. Inhibition of ER Ca2+ release or mitochondrial Ca2+ uptake in Cdk5?/? MEFs prevents mPTP opening, indicating that mPTP opening in Cdk5?/? MEFs is due to increased Ca2+ transfer from the ER to the mitochondria. Altogether, our findings suggest that Cdk5 regulates IP3R1-mediated calcium release and mitochondrial Ca2+ homeostasis that are disturbed upon Cdk5 loss, which lead to mPTP opening
(2020-2021) Clinical profile of febrile neutropenia in children with hematological malignancies
No full textPropagation of premixed flames in confined channels
No full textThe propagation of premixed flames in confined channels is investigated. In the unconfined case, the structure of the flame and the flame speed for the adiabatic planar flame have been numerically obtained and confirmed with the existing theory. It is seen that in the unconfined case, the flame propagates in nearly isobaric conditions with a constant flame speed whereas in the confined case there is pressure buildup which affects the flame speed. In the confined case, the time evolution of the flame is solved to obtain properties like the mass burning rate, pressure and flame location as a function of time, velocity field in the channel and propagation speed. Also the temperature and concentration profiles are obtained which give an insight in to the thickness of the flame region as the flame propagates through the entire channel. Effect of the Lewis number on the time taken for the flame to propagate the channel is examined. A non-linear analytical model that treats the flame as a discontinuity is also used to compare with the obtained numerical solution. This model requires only solving the hydrodynamic equations along with the Hugoniot jump relations across the flame front. The main difference between the numerical and the analytical solution is that the numerical solution takes into consideration a finite rate chemistry whereas in the analytical solution the reaction rate modeled as a delta function. Differences between the analytical and the numerical solution are compared.Item withdrawn by Mark Zulauf ([email protected]) on 2013-04-22T20:51:45Z
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Study of a passive pitching rotor using blade element momentum theory coupled to a rigid-body model
No full textMisaligned wind turbine rotors experience uneven loads because of two effects: dissymmetry of lift, and skewed wake effect. Rotor-crafts that have a similar problem introduce various mechanisms to combat this - one of them is to add a δ3-hinge. The hinge provides the blade with an additional degree of freedom to relieve the unbalanced loads; in theory, it is a self-correcting mechanism. In this work, we couple a blade element momentum (BEM) approach for the aerodynamics to a rigid-body model that simulates the hinge rotation. The results from BEM are used to identify the working mechanisms of the hinged rotor and highlight the strengths and weaknesses of such a rotor. Wind Energ
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