1,009 research outputs found
Myburgh 2022 Comparative Google Trends Plots.zip
No full textA series of 12 630 figures which was generated to visually inspect changes made to the Google Trends API is included here. In total, 421 different terms were included in the study, with data extracted for thirty countries. The period for extraction was 1 January 2019 - 27 May 2022, with extraction set to weekly search probabilities for the included keywords. The terms are omitted from these figures, as these form part of a different study that will soon be published.</p
Myburgh 2022 Detected anomalies in Google Trends update
No full textA set of time series and anomalies identified in the differences between data extracted from the Google Trends API before and after the changes to the sampling strategy.</p
The systemic and cerebrovascular effects of catecholamines under inhalational and intravenous anaesthesia / John Alexander Myburgh.
No full textBibliography: p. 162-186.xiv, 186 p. : ill. ; 30 cm.Adrenaline, noradrenaline and dopamine are widely used in intensive care medicine and anaesthesia. Isoflurane is used as an anaesthetic and propofol as an anaesthetic and sedative in intensive care. This study examines possible interactions between these drugs that could adversely effect cardiovascular and cerebrovascular function.Thesis (Ph.D.)--University of Adelaide, Dept. of Anaesthesia and Intensive Care, 200
Satellite cell pool expansion is affected by skeletal muscle characteristics
No full textINTRODUCTION We investigated changes in satellite cell (SC) pool size after an acute bout of strenuous exercise and evaluated the influence of baseline SC count and fiber type. METHODS Participants completed a downhill running (DHR) intervention (5 × 8 min, 2-min rest; 80% VO2max ; -10% gradient). Muscle biopsies were taken 7 days before VO₂max and 7-9 days after the DHR intervention. Delayed-onset muscle soreness (DOMS) and creatine kinase activity (CK) were measured on days 1, 2, 7, and 9 post-DHR. SCs were identified by Pax7 and laminin staining. Relative distribution of MHC isoforms was determined by electrophoresis. RESULTS DOMS and CK peaked on day 1 post-DHR (P < 0.01). The SC pool increased (26%) after DHR (P = 0.005). SCs/total myonuclei after recovery correlated with baseline SCs (r = 0.979, P = 0.003) and VO₂max (r = 0.956, P = 0.011), whereas change in SC pool (Pax7(+) cells/total myonuclei: recovery minus baseline) tended to correlate with percent MHC II (r = 0.848; P = 0.06). CONCLUSION Interindividual physiological characteristics affect SC pool expansion after a single bout of DHR and are influenced by VO₂max
sj-docx-1-ctj-10.1177_17407745221123248 – Supplemental material for Recruitment characteristics of randomised trials in critical care: A systematic review
No full textSupplemental material, sj-docx-1-ctj-10.1177_17407745221123248 for Recruitment characteristics of randomised trials in critical care: A systematic review by Mahesh Ramanan, Aashish Kumar, Laurent Billot, John Myburgh and Balasubramanian Venkatesh in Clinical Trials</p
Myburgh 2022 Time series difference plots of Google Trends API data with LOESS
No full textRecent changes to the Google Trends API resulted in potential changes to the way data from this resource is interpreted. Here we present 12 630 time series of the differences observed in values extracted from the Google Trends API before and after the said change was implemented. LOESS was applied to aid in the visual inspection of potential changes. Data was extracted for 421 search terms in thirty countries on 9-12 June 2022 (before) and 22 July 2022 (after). </p
The surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2008. An assessment by the Australian and New Zealand intensive care society
No full textHicks, P; Cooper, D J; Webb, S; Myburgh, J; Seppelt, I; Peake, S; Joyce, C; Stephens, D; Turner, A; French, C; Hart, G; Jenkins, I and Burrell, Ahttp://www.highbeam.com/doc/1P3-1470712151.htm
Detection of cerebral venous desaturation by continuous jugular bulb oximetry following acute neurotrauma.
No full textPublisher's copy made available with the permission of the publisher © 1995 Australian Society of AnaesthetistsA prospective observational study was performed to assess the reliability of fibreoptic oximetric catheters and to identify the incidence and causes of jugular bulb oxygen desaturation in patients with acute closed head injury. There were twenty-five patients (30 +/- 16 years) with GCS 10 minutes duration. There was a poor correlation for the first in vivo calibration (r2 = 0.602, P < 0.001, n = 25). Thereafter a close correlation between jugular bulb catheter and oximetry values was demonstrated (r2 = 0.868, P < 0.001, n = 205). Forty-two episodes of jugular bulb oxygen desaturation of 88 minutes mean duration (range 10 to 555) were observed. 83% occurred within 48 hours following injury. Hypocapnia was associated in 45% of episodes; hypoperfusion in 22%; raised ICP in 9% and a combination of the above in 24%. Validation with a laboratory oximeter is essential prior to continuous jugular bulb oximetry. Sustained episodes of cerebral venous desaturation are frequent within the first 48 hours following acute head injury. Factors such as hypocapnia and cerebral hypoperfusion that primarily reduce cerebral blood flow are predominant.S.B. Lewis, J.A. Myburgh, P.L. Reill
Three-year change in oxidative stress markers is linked to target organ damage in black and white men: the SABPA study
No full textOxidative stress is implicated in hypertension, carotid wall thickening, and renal dysfunction. Oxidative stress is linked to cardiovascular pathology in the black South African individuals who have a high prevalence of hypertension and early vascular aging. However, there are limited data relating changes in oxidative stress with vascular and renal deterioration over time. We aimed to investigate whether changes in oxidative stress over 3 years are associated with target organ damage in black (N = 89) and white (N = 91) men. Carotid intima-media thickness was measured using the SonoSite Micromaxx ultrasound system, and cross-sectional wall area (CSWA) was calculated. The estimated glomerular filtration rate (eGFR) was calculated using the Modification of Diet in Renal Disease formula. The percentage change (%∆) in oxidative stress markers was calculated and included reactive oxygen species (ROS), superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GR). Over 3 years, black men exhibited decreased ROS, SOD, and GR, while white men revealed decreased SOD and GPx. Black men displayed positive associations of CSWA with %∆ ROS (β = 0.28; p = 0.017) and %∆ SOD (β = 0.24; p = 0.047). White men displayed a negative association of CSWA with %∆ SOD (β = −0.22; p = 0.042) and positive associations of eGFR with %∆ GPx (β = 0.33; p = 0.001) and %∆ GR (β = 0.39; p < 0.001). In white men, the association of CSWA with decreased SOD activity suggests oxidative-stress-related carotid remodeling, while associations of eGFR with the glutathione system suggests a postponement of microvascular deterioration. In black men, associations of oxidative stress markers with CSWA suggest that a sufficiently functioning antioxidant system may delay target organ damag
Effect of irrigation with diluted winery wastewater on phosphorus in four differently textured soils
No full textCITATION: Mulidzi, A. R., Clarke, C. E. & Myburgh, P. A. 2016. Effect of irrigation with diluted winery wastewater on phosphorus in four differently textured soils. South African Journal for Enology and Viticulture, 37(1): 79-84, doi:10.21548/37-1-761.The original publication is available at http://www.journals.ac.za/index.php/sajevThe wine industry needs solutions for wastewater treatment, as environmental legislation for its disposal is
increasingly being enforced due to non-compliance. The feasibility of re-using diluted winery wastewater
was assessed in a pot experiment under a rain shelter over four simulated irrigation seasons. Four soils
varying in parent material and clay content, viz. aeolic sand from Lutzville containing 0.4% clay, alluvial
sand from Rawsonville containing 3.3% clay, granite-derived soil from Stellenbosch containing 13% clay,
and shale-derived soil from Stellenbosch containing 20% clay, were irrigated with wastewater diluted to
3 000 mg/L COD (chemical oxygen demand), whereas the control received municipal water. Irrigation with
diluted winery wastewater increased the pH(KCl) in the shale- and granite-derived soils into the optimum
range for P availability. Although pH(KCl) in the aeolic sand was initially above the optimum range, relatively
high Na+ levels also caused available P to increase as the pH(KCl) increased. The pH(KCl) in the alluvial sand
increased beyond the optimum range, thereby causing a reduction in the available P. This indicates that
irrigation with diluted winery wastewater may only enhance P absorption if the pH(KCl) shift is towards the
optimum. It must be noted that the results represent a worst-case scenario, i.e. in the absence of rainfall
or crops.http://www.journals.ac.za/index.php/sajev/article/view/761Publisher's versio
- …
