812 research outputs found
The Centennial Triple Operatic Hymn.
No full text3 sections, each strophic with chorus; two choruses, none after section 1piano and voice First line (of section 1) To age we're yet in infancy, tho' a nation full of fame First line of chorus (of section 2) Now give us applause, Hurrah!Dedicated by the U.S. to the Nations of the UniverseJohns Hopkins University, Levy Sheet Music Collection, Box
132, Item 072Piano Arranged and Triple Song. "Thus Vox Populi Vox Deo." To Sentiments Within None Competito With These the Author E. Ludewig Kurtz, New York City
The Centennial Triple Operatic Hymn.
No full text3 sections, each strophic with chorus; two choruses, none after section 1piano and voice First line (of section 1) To age we're yet in infancy, tho' a nation full of fame First line of chorus (of section 2) Now give us applause, Hurrah!Dedicated by the U.S. to the Nations of the UniverseJohns Hopkins University, Levy Sheet Music Collection, Box
132, Item 072Piano Arranged and Triple Song. "Thus Vox Populi Vox Deo." To Sentiments Within None Competito With These the Author E. Ludewig Kurtz, New York City
Panorama von Kreuznach und seinen nächsten Umgebungen : (mit 8 Randbildern) ; nebst e. Plane d. Stadt
No full textmit Text von J. H. Ludewig. Nach d. Natur gezeichnet, in Stahl gestochen u. hrsg. v. P. Bornige
Anmerkungen und Zusätze zu Johann Ludewig Julius Dedekind's Einleitung zum Prozesse der Herzogl. Braunschweig-Wolffenbüttelschen Gerichte / gesammlet und herausgegeben vom Assessor P. C. A. Lilly
No full textDas Bild des Marranentums in 19. und 20. Jahrhundert
No full textFerruta P, Lund HL, Ludewig A-D, eds. Das Bild des Marranentums in 19. und 20. Jahrhundert. Hildesheim: Olms; In Press
Interaction of vascular endothelial cells with CD8+ T-cells in vivo
No full textTransplantation of organs and cells saves and prolongs thousands of lives every year. Surgical techniques were significantly improved but major problems remain, in particular the host’s immune system. Despite advances in immunosuppressive therapies, chronic allograft rejection still occurs which is characterized by intimal thickening in the arteries and the replacement of graft parenchyma, a phenomenon called chronic transplant vasculopathy (CTV). Within three years after transplantation 45% of transplant patients are affected by CTV which leads to the failure of allografts of about 5% each year post transplantation. The reasons for its development and the mechanistic basis inducing CTV are still not clearly understood. In graft versus host disease (GVHD) and vascular rejection of solid organ transplants, vascular endothelial cells (EC) have been recognized as important targets for alloreactive cytotoxic T-lymphocytes (CTL) and the presence of CTL has been associated with CTV. Therefore, T-cell-mediated immunity and subsequent inflammation appear to be important features of the initiation and progression of CTV. The contribution of EC to CD8+ T-cell activation and therefore their role in the development of chronic vascular rejection is still controversially discussed. For that reason and the fact that after transplantation of vascularised organs EC are the first graft cells encountered by host lymphocytes, the detailed interaction of vascular EC with CD8+ T-cells has been assessed in vivo in the first part of our study, in order to find out whether EC are able to activate or tolerize naive CD8+ T-cells. Using a transgenic mouse model with beta-galactosidase (β-gal) expression confined to the vascular endothelium (Tie2-LacZ mice) and the help of β-gal TCR transgenic CD8+ T-cells (Bg1 mice), the capacity of EC presenting a minor histocompatibility antigen (mhAg) to induce a CD8+ T-cell response was studied. We could show that mhAg presentation on EC was ignored by CD8+ T-cells and was neither sufficient to activate nor to tolerize CD8+ T-cells. Moreover, the mhAg was cross-presented by BM-derived CD11c+ DC and led to spontaneous activation of β-gal-specific CD8+ T-cells in Tie2-LacZ mice. This identifies the priming of mhAg-specific CD8+ T-cells via DC as the critical step in the generation of alloimmune responses. Furthermore, no β-gal-specific CD8+ T-cell activation was induced after transplantation of fully vascularised heart or liver grafts from Tie2-LacZ mice into non-transgenic recipients confirming that CD8+ T-cell responses against mhAg cannot be initiated by EC.
In the second part of the study the major aim was to develop an experimental system that facilitates in vivo studies on the interaction of EC with activated CTL in a heart transplantation model. To this end, Tie2-LacZ hearts were heterotopically transplanted into C57BL/6 recipients. Tie2-LacZ hearts were accepted and showed no vascular inflammatory changes or neointima formation until day 100 post transplantation. Repetitive priming with β-gal peptide loaded DC induced a long-term β-gal-specific CTL response resulting in the induction of vascular inflammatory disease with neointima formation and vascular occlusion. Infection with β-gal recombinant mouse cytomegalovirus (MCMV-LacZ) however, led to a shorter activation of β-gal-specific CTL and thus to a less significant vascular inflammation in Tie2-LacZ hearts. Taken together, we suggest that it is the prolonged presentation of mhAg within secondary lymphoid organs that is responsible for the activation of EC-specific CTL and that activated CTL recognize thereafter mhAg specifically expressed on EC, leading to the development of chronic vascular rejection
3002. Extraits de différents comptes du règne de Philippe le Bel, dans J.-P. Ludewig, Reliquiae manuscriptorum omnis aevi diplomatum ac monumentorum ineditorum adhuc , XII
No full text3002. Extraits de différents comptes du règne de Philippe le Bel, dans J.-P. Ludewig, Reliquiae manuscriptorum omnis aevi diplomatum ac monumentorum ineditorum adhuc , XII. In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). III. Les Capétiens, 1180-1328. Paris : A. Picard et fils, 1903. p. 227
2681. Pallia militum et clericorum hospitii regis (Pentecôte 1231), dans Ludewig, Reliquiae manuscr., XII, 1-3
No full text2681. Pallia militum et clericorum hospitii regis (Pentecôte 1231), dans Ludewig, Reliquiae manuscr., XII, 1-3. In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). III. Les Capétiens, 1180-1328. Paris : A. Picard et fils, 1903. p. 145
2681. Pallia militum et clericorum hospitii regis (Pentecôte 1231), dans Ludewig, Reliquiae manuscr., XII, 1-3
No full text2681. Pallia militum et clericorum hospitii regis (Pentecôte 1231), dans Ludewig, Reliquiae manuscr., XII, 1-3. In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). III. Les Capétiens, 1180-1328. Paris : A. Picard et fils, 1903. p. 145
The Form of N Supply Determines Plant Growth Promotion by P-Solubilizing Microorganisms in Maize.
No full textPhosphate-(P)-solubilizing microorganisms (PSM) are important drivers of P cycling in natural and agro-ecosystems. Their use as plant inoculants to improve P acquisition of crops has been investigated for decades. However, limited reproducibility of the expected effects, particularly under field conditions, remains a major challenge. This study demonstrates that the form of nitrogen fertilization has a significant impact on the performance of various fungal and bacterial PSM inoculants in maize grown on neutral to alkaline soils with limited P availability. Under these conditions, a high soil pH-buffering capacity frequently limits the efficiency of nutrient mobilization, mediated by plant roots and microorganisms via rhizosphere acidification. In a soil pH range between 7.0 and 8.0, nitrate fertilization promoting rhizosphere alkalinisation further aggravates this problem. Accordingly, in greenhouse experiments, six strains of Pseudomonas, Bacillus, Paenibacillus, Streptomyces, and Penicillium with proven P-solubilizing potential, completely failed to promote P acquisition in maize grown on a calcareous Loess sub-soil pH 7.6 with nitrate fertilization and rock phosphate (Rock-P) as a sparingly soluble P source. However, after replacement of nitrate fertilization by ammonium, stabilized with the nitrification inhibitor 3,4-dimethylpyrazole-phosphate (DMPP), five out of seven investigated PSM inoculants (comprising 12 fungal and bacterial PSM strains) exerted beneficial effects on plant growth and reached up to 88% of the shoot biomass production of a control supplied with soluble triple-superphosphate (TSP). Stabilized ammonium combined with PSM-inoculants improved P acquisition (Trichoderma harzianum T22, Pseudomonas sp. DMSZ 13134), while other strains particularly stimulated root growth (T. harzianum OMG16, Bacillus amyloliquefaciens FZB42), which promoted the acquisition also of other mineral nutrients, such as N, K, and Mn. A similar effect was recorded under field conditions on an alkaline clay-loam soil pH 8.6. The combination of stabilized ammonium with a range of consortium products based on T. harzianum OMG16, B. amyloliquefaciens, micronutrients, and humic acids completely compensated the effect of a TSP fertilization on field establishment, nutrient acquisition, and yield formation in maize, while non-stabilized urea-di-ammonium phosphate fertilization was largely ineffective. These findings suggest that the efficiency of PSM-plant interactions can be influenced by the form of N fertilization, offering promising perspectives for synergistic effects with stabilized ammonium fertilizers
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