38 research outputs found
Effects of the bradykinin B2 receptor antagonist S 16118 (p-guanidobenzoyl-[Hyp3,Thi5,D-Tic7,Oic8]bradykinin) in different in vivo animal models of inflammation
No full text: The effects of S 16118 (p-guanidobenzoyl-[Hyp3,Thi5,D-Tic7, Oic8]bradykinin (BK)], a new, potent and long-acting BK B2 antagonist, were tested in some in vivo models of inflammation. In rats, S 16118 (0.1 and 1 mg/kg) given i.v. or s.c. delayed the edema formation induced by intraplantar carrageenan injections up to 4 hr after administration, confirming the involvement of kinins in this inflammatory reaction. In guinea pigs treated with atropine, vagal stimulation induced bronchial microvascular leakage. Aerosolization of S 16118 (5 x 10(-3) M for 20 sec), 4 min before vagus nerve stimulation, induced a 60% decrease in the Evans blue extravasation, demonstrating the modulatory role of BK in neurogenic inflammation. In rats, caerulein infusion (4 nmol/kg/hr) induced hypotension, massive pancreatic edema, hypovolemia due to plasma leakage and an increase in serum lipase and amylase activity. S 16118 (100 nmol/kg s.c.) prevented the hypotension, the pancreatic edema and the hypovolemia and induced a marked increase in the serum lipase and amylase activity. This confirms that BK, acting on BK B2 receptors, is involved in this model of pancreatitis. In rabbits, the injection of lipopolysaccharides (LPS; 600 micrograms/kg i.v.) induced hypotension, metabolic acidosis and leukopenia. S 16118 (1.73 mumol/kg i.v.) did not influence the effects of LPS injection. In mice, i.p. LPS (25 mg/kg) administration induced over 90% mortality in 96 hr. S 16118 (1 mg/kg x 4), given 30 min before LPS injection and 4, 8 and 24 hr after LPS injection, did not influence the mortality rate.(ABSTRACT TRUNCATED AT 250 WORDS
Arithmétique théorique et pratique pour l'enseignement secondaire classique et pour l'enseignement secondaire professionnel, conforme au dernier programme, par A. lonchampt,...
No full textAvec mode text
Effects of the Bradykinin B2 Receptor Antagonist S 16118 (p-Guanidobenzoyl-[Hyp3,Thi5,D-Tic7,Oic8]Bradykinin) in Different in Vivo Animal Models of Inflammation
No full textABSTRACT The effects of S 1 61 1 8 {p-guanidobenzoyl-[Hyp3,Thi5,D-Tic7
Éléments de bibliographie
No full textAvant-scène (L’), « L’après-midi d’un faune », Paris, coll. Ballet/danse, 1982. Aguettant (Louis), Victor Hugo, poète de la nature, texte établi par Jeanne et Jacques Lonchampt, L’Harmattan, 2000. Barrère (Jean-Bertrand), La Fantaisie de Victor Hugo, José Corti, 1950, 3 tomes. Bartholomot-Bessou (Marie-Ange), L’Imaginaire du féminin dans l’œuvre de Renée Vivien, Clermont-Ferrand, Presses universitaires Blaise Pascal, 2004, coll. Cahiers romantiques, 439 p. Beck (Adolf), Hölderlins Diotima Sus..
Assessing marine operations with a Markov-switching autoregressive metocean model
No full textThis is the author accepted manuscript. The final version is available from the publisher via the DOI in this recordThis article presents a metocean modelling methodology using a Markov-switching autoregressive model to produce stochastic wind speed and wave height time series, for inclusion in marine risk planning software tools. By generating a large number of stochastic weather series that resemble the variability in key metocean parameters, probabilistic outcomes can be obtained to predict the occurrence of weather windows, delays and subsequent operational durations for specific tasks or offshore construction phases. To cope with the variation in the offshore weather conditions at each project, it is vital that a stochastic weather model is adaptable to seasonal and inter-monthly fluctuations at each site, generating realistic time series to support weather risk assessments. A model selection process is presented for both weather parameters across three locations, and a personnel transfer task is used to contextualise a realistic weather window analysis. Summarising plots demonstrate the validity of the presented methodology and that a small extension improves the adaptability of the approach for sites with strong correlations between wind speed and wave height. It is concluded that the overall methodology can produce suitable wind speed and wave time series for the assessment of marine operations, yet it is recommended that the methodology is applied to other sites and operations, to determine the method’s adaptability to a wide range of offshore locations.Energy Technologies Institute (ETI)Research Councils UK (RCUK)Energy programme for the Industrial Doctorate Centre for Offshore Renewable Energy (IDCORE
Overview of EDF Life Cycle Management and Nuclear Asset Management Methodology and Tools
No full textAcetylcholine-induced endothelium-dependent contractions in the SHR aorta: The Janus face of prostacyclin
No full text1 In the spontaneously hypertensive rat (SHR) and aging Wistar-Kyoto rats (WKY), acetylcholine releases an endothelium-derived contracting factor (EDCF) produced by endothelial cyclooxygenase-1, which stimulates thromboxane A 2 receptors (TP receptors) on vascular smooth muscle. The purpose of the present study was to identify this EDCF by measuring changes in isometric tension and the release of various prostaglandins by acetylcholine. 2 In isolated aortic rings of SHR, U 46619, prostaglandin (PG) H 2, PGF 2α, PGE 2, PGD 2, prostacyclin (PGI 2) and 8-isoprostane, all activate TP receptors of the vascular smooth muscle to produce a contraction (U 46619≫8-isoprostane=PGF 2α=PGH 2>PGE 2=PGD 2> PGI 2). The contractions produced by PGH 2 and PGI 2 were fast and transient, mimicking endothelium-dependent contractions. PGI 2 did not relax isolated aortic rings of WKY and SHR. 3 Acetylcholine evoked the endothelium-dependent release of thromboxane A 2, PGF 2α, PGE 2, PGI 2 and most likely PGH 2 (PGI 2≫PGF 2α≥PGE 2>TXA 2>8-isoprostane, PGD 2). Dazoxiben abolished the production of thromboxane A 2, but did not influence the endothelium-dependent contractions to acetylcholine. 4 The release of PGI 2 was significantly larger in the aorta of SHR than in WKY, and the former was more sensitive to the contractile effect of PGI 2 than the latter. The inhibition of PGI-synthase was associated with an increase in PGH 2 spillover and the enhancement of acetylcholine-induced endothelium-dependent contractions. 5 Thus, in the aorta of SHR and aging WKY, the endothelium-dependent contractions elicited by acetylcholine most likely involve the release of PGI 2 with a concomitant contribution of PGH 2. © 2005 Nature Publishing Group All rights reserved.link_to_OA_fulltex
Data-Informed Lifetime Reliability Prediction for Offshore Wind Farms
No full textThis is the author accepted manuscript. The final version is available from IEEE via the DOI in this recordOffshore wind operation and maintenance (O&M) costs can reach up to 1/3 of the overall project costs. In order to accelerate the deployment of these clean energy assets, costs need to come down. This requires, a good understanding of the different operations along with a robust planning, maintenance and monitoring strategy. Asset management tools have been developed, which require reliability inputs, able to estimate the lifetime operational expenditure (OPEX) and optimize the maintenance strategies for the assets. The lack of large datasets with offshore wind failure rate data in the literature increases the uncertainty in the estimations made by those tools. This paper aims to compare whether the publicly available data could provide an accurate information of the lifetime reliability predictions of the assets. It initially uses a generic average failure rate, taken from literature to model the wind farm; as most wind farm developers will not have any detailed understanding of the reliability of the asset prior to construction. It then uses a more detailed, turbine-specific model, taking into account reliability data from an operational wind farm. Results show a small overall difference when the model uses the data-informed parameters, by up to 0.4% in the overall availability. Moreover, it is shown that the use of generic values can create more pessimistic results compared to the data-informed data. The results of the paper are of interest to offshore wind farm developers and operators aiming to improve their lifetime reliability estimations and reduce the O&M costs of the offshore wind farms.Energy Technology InstituteEngineering and Physical Sciences Research Council (EPSRC)EDF Energ
Trigeminal neuralgia, migraine and sympathetic hyperactivity in a patient with Parry–Romberg syndrome
No full textParry–Romberg syndrome is a rare disorder of unknown aetiology that involves slowly progressive but self-limited wasting of subcutaneous tissues on one side of the face, usually in the distribution of a branch of the trigeminal nerve. In an internet survey of 205 people on the mailing list of the ‘Romberg's Connection’ site, 52% reported suffering from migraine and 46% from facial pain, almost always affecting the same side as the atrophy. Headaches and facial pain have also featured in case reports, sometimes in association with an intracranial aneurysm or radiological signs of ipsilateral brain pathology.
We had the opportunity to examine trigeminal and cervical sympathetic nerve function in a woman with right-sided Parry–Romberg syndrome, migraine and trigeminal neuralgia. We wished to determine whether signs of trigeminal or cervical sympathetic hyperactivity were associated with the facial hemiatrophy, because aberrant cranial nerve function has been implicated in the pathophysiology of Parry–Romberg syndrome
