1,042 research outputs found
Microfluidic generation of biomaterial gradients for control of neurite outgrowth
No full textEnhancing and directing axon regeneration through an injury site represents a prime goal for therapies following nerve or spinal cord injury. The objective of this thesis is to develop a system to create durotactic and haptotactic gradients with a biomaterial scaffold for control of neural cell behavior. Gradients of mechanical properties and adhesion are generated in a 3D collagen gel using microfluidics. To spatially control the mechanical properties, gradients of genipin - a naturally occurring, cell-tolerated crosslinking agent - are created in 3D through a fibrillar collagen gel using a simple source-sink network. Durotactic gradients of mechanical properties are evaluated by measuring genipin-induced fluorescence, which we demonstrated can be correlated to the rheological properties of the collagen gel. Neurite growth from chick dorsal root ganglia was assayed in gradients and appropriate controls. Neurite growth was biased down a gradient of stiffness of ~60Pa/mm towards a more compliant region, and neurites were significantly longer in this direction than up the gradient and than in uniform conditions without crosslinking. Haptotactic gradients are generated by first grafting laminin derived peptides, IKVAV and YIGSR, onto the collagen backbone using 1-ethyl-3-(3-Dimethylaminopropyl) carbodiimide (EDC). Peptide-grafted collagen solutions are mixed with untreated collagen in the network Neurite outgrowth was enhanced in all laminin peptide-grafted collagen gradient conditions compared to the untreated collagen controls. Neurite growth was more responsive to gradients of YIGSR than IKVAV. Enhanced growth was observed in all YIGSR-grafted conditions with the greatest bias in the steepest gradient of (24.7 ??g/ml/mm). Enhanced growth was also observed in IKVAV-grafted collagen conditions, but stunted growth occurred in collagen with uniform IKVAV presentation, implying IKVAV may be too 'sticky' for neurite outgrowth at the highest concentration studied. Since both peptides are present on the whole-length laminin molecule, the results suggest that gradients of laminin would be sub-optimal because of the contradiction in the response to the two peptides. These results demonstrate that neurite growth can be enhanced and directed by durotactic and haptotactic gradients, and suggest that including a combination of these gradients in regenerative therapies may accelerate nerve and spinal cord regeneration.Ph. D.Includes bibliographical references (p. 115-122).by Harini Sundararaghava
PERADILAN KASUS GRATIFIKASI HARINI WIJOSO . (SEBUAH ANALISIS-KRITIS)
No full textAbstrakThe author elaborates concerning the corruption case's which involvedformer judge Harini Wijoso whom acting her recent advocate jobs forProbosutedjo as the accused corruption's actor. The advocate here thenbecomes accused also by doing corruption practices on bribery ways. In thecourt 's session the accusation of public prosecutors to Harini have reflectedthe criminal effords. Under Indonesian Criminal Law its classified asformeel delicten' (formal offensive) which then has qualified Probosutedjoas the involved aclor of crime perfomers. In fact then Corruption EradicationComission (KPK) has overulled through Probosutedjo as the accused. Theauthor here has thought that Probosutedjo is not the whistle blower byhimself involved on criminal conduct's, In this case the KPK have practicedinconsistency and abuse du droit by considering that KPK haven'tauthorized to suspend the investigation or due process of prosecution</jats:p
Efficacy of a probiotic and chlorhexidine mouth rinses: A short-term clinical study
No full textIntroduction: Probiotic technology represents a breakthrough approach to maintaining oral health by utilizing natural beneficial bacteria commonly found in healthy mouths to provide a natural defense against those bacteria thought to be harmful to teeth and gums. However, data are still sparse on the probiotic action in the oral cavity. The review article on probiotics in children published by Twetman and Stecksen- Blicks in 2008 showed only one study of dental interest on probiotics in children. Aim and Objectives: The present study evaluated clinically the efficacy of a probiotic and chlorhexidine mouth rinses on plaque and gingival accumulation in children. The trial design is a double-blind parallel group, 14 days comparative study between a probiotic mouth rinse and a chlorhexidine mouth rinse, which included 45 healthy children in the age group of 6-8 years. Results: The Probiotic and Chlorhexidine groups had less plaque accumulations compared with the Control group at the end of 14 years (P < 0.001 and P < 0.001, respectively). But, unlike the plaque score, there was a significant difference in the Gingival Index between the Probiotic and the Chlorhexidine groups (P = 0.009), Probiotic group being better than the Chlorhexidine group (mean = 0.2300 and 0.6805, respectively). Conclusion: The Probiotic mouth rinse was found effective in reducing plaque accumulation and gingival inflammation. Therefore, probiotic mouth rinse obviously has a potential therapeutic value and further long-term study is recommended to determine its efficacy
sj-docx-1-gae-10.1177_25168657221135848 – Supplemental material for The Neuroepigenetic Landscape of Vertebrate and Invertebrate Models of Neurodegenerative Diseases
No full textSupplemental material, sj-docx-1-gae-10.1177_25168657221135848 for The Neuroepigenetic Landscape of Vertebrate and Invertebrate Models of Neurodegenerative Diseases by Thanga Harini Sundaramoorthy and Isabel Castanho in Epigenetics Insights</p
Detecting Driver Fatigue Through the Use of Advanced Face Monitoring Techniques
No full textDriver fatigue is an important factor in many vehicular accidents. Reducing the number of fatigue-related accidents would save society a significant amount financially, in addition to reducing personal suffering. The researchers developed a driver fatigue monitoring system that uses a camera (or cameras) to detect indications of driver fatigue. The mechanism detects and tracks the eyes of the driver based on human skin color properties, along with templates that monitor how long the eyes are open or closed. Tests of the approach were run on 20 human subjects in a simulated environment (the driving simulator at the Human Factors Research Laboratory) in order to find its potential and its limitations. This report describes the findings from these experiments.ITS InstituteVeeraraghavan, Harini; Papanikolopoulos, Nikolaos P.. (2001). Detecting Driver Fatigue Through the Use of Advanced Face Monitoring Techniques. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/669
sj-pdf-1-bbi-10.1177_11779322211037769 – Supplemental material for Ligand Docking Methods to Recognize Allosteric Inhibitors for G-Protein-Coupled Receptors
No full textSupplemental material, sj-pdf-1-bbi-10.1177_11779322211037769 for Ligand Docking Methods to Recognize Allosteric Inhibitors for G-Protein-Coupled Receptors by K Harini, S Jayashree, Vikas Tiwari, Sneha Vishwanath and Ramanathan Sowdhamini in Bioinformatics and Biology Insights</p
Disease Detection in Plant Leaves using K-Means Clustering and Neural Network
No full textThe most contributing variable for the Indian Economy is Agriculture yet at the same time there is absence of mechanical improvement in many parts of it. The harm caused by rising, re developing and endemic pathogens, is vital in plant frameworks and prompts potential misfortune. The harvest generation misfortunes its quality because of much infections and some of the time they happen however are indeed, even not obvious with stripped eyes. Plant malady recognition is one such dull process that is hard to be inspected by exposed eye. This paper shows an answer utilizing image processing calculations by loading the image, preprocessing and feature extraction using K means clustering and segmentation method to identify the disease with which the plant leaf been affected. P. Harini | V. Chandran "Disease Detection in Plant Leaves using K-Means Clustering and Neural Network" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1 , December 2019, URL: https://www.ijtsrd.com/papers/ijtsrd29562.pd
On-field management and return-to-play in sports-related concussion in children: Are children managed appropriately?
No full textsj-pdf-1-jrs-10.1177_01410768231156997 - Supplemental material for Intensive versus standard blood pressure control in older persons with or without diabetes: a systematic review and meta-analysis of randomised controlled trials
No full textSupplemental material, sj-pdf-1-jrs-10.1177_01410768231156997 for Intensive versus standard blood pressure control in older persons with or without diabetes: a systematic review and meta-analysis of randomised controlled trials by Samuel Seidu, Harini Willis, Setor K Kunutsor and Kamlesh Khunti in Journal of the Royal Society of Medicine</p
Hallucination As Psychotic Symptom Reflected In Aronofsky’s Black Swan Movie (2010): A Psychoanalytic Approach
Get PDFSUMMARY
FITRIAYU DIAH HARINI. A320 080 206. HALLUCINATION AS
PSYCHOTIC SYMPTOM REFLECTED IN ARONOFSKY’S BLACK
SWAN MOVIE (2010): A PSYCHOANALYTIC APPROACH.
MUHAMMADIYAH UNIVERSITY OF SURAKARTA. RESEARCH
PAPER. 2012.
The major problem of this study is to reveal that hallucination can be a
psychotic symptom that caused by many problems based on the structural
elements and to analyze the play based on the psychoanalytic approach.
In analyzing Black Swan the writer uses qualitative method and
psychoanalytic approach. The object of the study is Aronofsky’s Black Swan
released 2010. The writer uses two kinds of data, namely primary and
secondary data source. The primary data is Black Swan. While secondary data
are the other data which have relationship with the study, such as some
biography of the author, the articles from internet, the books and the other
relevant information. The benefit of this study is that the research can enrich
knowledge of the researcher and other reader who have interest in literary
work on movie with a psychoanalytic approach.
Aronofsky in Black Swan shows that people have limitation in psyche
and they should have a balance between id, ego and superego to get
psychological health. Nina Sayers, as the major character describes and shows
the effects of psychological disorder in form of hallucination that closel
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