353 research outputs found
Koronka wielostopniowa do wiercenia otworów w skałach opis patentowy patentu tymczasowego nr 99810 /
No full textTyt. z ekranu tyt.Zgłoszono 30 października 1976 r.Numer zgłosz. P.193393.Zgłoszenie ogłoszono 29 sierpnia 1977 r.Opublikowano 15 grudnia 1978 r.Pozostali twórcy wynalazku: Tadeusz Missygar, Jan Parfiniewicz, Andrzej Kędziora, Mieczysław Drewnicki, Bogdan Gruca, Benedykt Natkaniec, Wiesław Grębski, Winicjusz Leszczyński.Dostępny także w wersji drukowanej.Tryb dostępu: Internet
sj-pdf-1-jmx-10.1177_00222429231207830 - Supplemental material for Bringing the Doctor to the Patients: Cardiology Outreach to Rural Areas
No full textSupplemental material, sj-pdf-1-jmx-10.1177_00222429231207830 for Bringing the Doctor to the Patients: Cardiology Outreach to Rural Areas by J. Jason Bell, Sanghak Lee and Thomas S. Gruca in Journal of Marketing</p
Chronic mild stress-induced alterations of local protein synthesis: a role for cognitive impairment
No full textDepression, a major cause of disability worldwide, is characterized by a complex and heterogeneous symptomatology. With this respect, cognitive deterioration represents a major problem that has a strong impact on patient's function. Thus, within the context of a depressive phenotype, it is important to characterize the mechanisms that sustain cognitive dysfunctions and may represent an important target for pharmacological intervention. Here, using the chronic mild stress (CMS) paradigm of depression, we found that, independently from the anhedonic phenotype, CMS rats showed a deficit in the novel object recognition (NOR) test, which is associated with an inability to phosphorylate GluN2B subunit on Ser1303 and to activate the mTOR pathway. In agreement with the role of these systems in the control of local protein synthesis, we observed an increase phosphorylated of the eukaryotic Elongation Factor 2 (eEF2) in the crude synaptosomal fraction after the NOR test specifically in control animals. Since it has been demonstrated that peEF2 leads to the translation of specific mRNAs, we investigated if the gene-specific translational control depends on the presence of uORFs. Interestingly, we found a significant increase of oligophrenin-1 (2 uORFs) and of Bmal1 (7 uORFs) protein levels specifically in the control animals exposed to the NOR test. Our results demonstrated that the cognitive decline associated with stress exposure might be due to alterations in local protein translation of specific mRNAs, suggesting that a pharmacological intervention able to correct these defects might be useful in the improvement of deteriorated functions in patients with major depression and stress-related disorders
Effect of lurasidone treatment on chronic mild stress-induced behavioural deficits in male rats: The potential role for glucocorticoid receptor signalling
No full textBackground: Stress represents one of the main precipitating factors for psychiatric diseases, characterised by an altered function of glucocorticoid receptors (GR), known to play a role in mood and cognitive function. We investigated the ability of the antipsychotic lurasidone to modulate the involvement of genomic and non-genomic GR signalling in the behavioural alterations due to chronic stress exposure Methods: Male Wistar rats were exposed to seven weeks of chronic mild stress (CMS) and treated with lurasidone (3 mg/kg/day) starting from the second week of stress for more five weeks. Gene expression and protein analyses were conducted in dorsal hippocampus. Results: Seven weeks of CMS induced anhedonia and cognitive impairment, which were normalised by lurasidone. At molecular level, CMS rats showed an increase of GR protein levels by 60% (p<0.001 vs. CTRL/VEH) in the membrane compartment, which was paralleled by an up-regulation of phosphoSINAPSYN Ia/b by 88% (p<0.01 vs. CTRL/VEH) and of the mitochondrial marker Cox3 by 21% (p<0.05 vs. CTRL/VEH). Moreover, while exposure to the novel object recognition test increased the nuclear translocation of GRs by 96% (p<0.01 vs. CTRL/VEH/Naïve) and their transcriptional activity in non-stressed rats, such mechanisms were impaired in CMS rats. Interestingly, the genomic and non-genomic alterations of GR, induced by CMS, were normalised by lurasidone. Conclusion: Our results further support the role of glucocorticoid signalling in the dysfunction associated with stress exposure. We provide novel insights on the mechanism of lurasidone, suggesting its effectiveness on different domains associated with psychiatric disorders
sj-pdf-1-jop-10.1177_02698811211048281 – Supplemental material for Insufficiency of ventral hippocampus to medial prefrontal cortex transmission explains antidepressant non-response
No full textSupplemental material, sj-pdf-1-jop-10.1177_02698811211048281 for Insufficiency of ventral hippocampus to medial prefrontal cortex transmission explains antidepressant non-response by Mariusz Papp, Piotr Gruca, Magdalena Lason, Ewa Litwa, Wojciech Solecki and Paul Willner in Journal of Psychopharmacology</p
Inter-Nord
No full textOn 5 February 2024, Professor Jean Malaurie passed away at his home in Dieppe at the age of 101. Having refused to join the compulsory work service (STO – Service du travail obligatoire) of the Nazi occupant in 1943, he went into hiding, joining the Résistance movement, an act of recalcitrance which characterized him profoundly and which was to entitle him to military honours during his funeral. The ceremony took place at the Saint-Louis-des-Invalides Cathedral in Paris on 14 February 2024, followed by the military honours and eulogy pronounced by the French Minister of Higher Education and Research, Professor Sylvie Retailleau.
It is with emotion that the editorial board of Inter-Nord wishes him farewell, paying a last tribute to the President of honour of our journal which he had founded with historian Fernand Braudel at the CNRS in the 1960s. We are publishing in French and English the homily of Father Geoffroy de la Tousche, the final remarks by Jean Malaurie’s son Guillaume and the minister’s speech, as well as a homage published in Le Canard enchaîné and a letter of condolences by Mrs Audrey Azoulay, Director-General of UNESCO.
Inter-Nord 23 continues in the interdisciplinary and intersectorial vein which has been its imprint introduced by Jean Malaurie right from the start, trying to propose bilingual versions of texts as far as possible. The current issue contains a special section with three scientific research articles on Iceland, two of which were first presented at the annual Humanities conference of the University of Iceland in 2023. These texts are accompanied by graphic works of the Icelandic artist Thóra Sigurðardóttir. Many thanks to Thóra for letting us publish some of her intriguing artwork discussed in a stunning piece by the Icelandic poetess Sigurbjörg Thrastardóttir.
In the creative writing section, we are also publishing two pieces by the Quebecois author Monique Durand about the Faroe Islands and interviews with Alaskan author Nancy Lord and the journalist Olivera Tornau. Other contributions include a viewpoint signed by four UArctic Chairs, an original French research project and some reviews of Malaurie’s and other works
Stress-induced anhedonia is associated with the activation of the inflammatory system in the rat brain : restorative effect of pharmacological intervention
No full textMajor depression is a complex disease that originates from the interaction between a genetic background of susceptibility and environmental factors such as stress. At molecular level, it is characterized by dysfunctions of multiple systems including neurotransmitters, hormones, signalling pathways, neurotrophic and neuroplastic molecules and - more recently - inflammatory mediators. Accordingly, in the present study we used the chronic mild stress (CMS) paradigm in the rat to elucidate to what extent brain inflammation may contribute to the development and/or the maintenance of an anhedonic phenotype and how pharmacological intervention may interfere with such behavioral and molecular stress-induced alterations. To this aim, adult male rats were exposed to CMS for 2 weeks and the cerebral expression of several mediators of the inflammatory system was evaluated in the hippocampus and prefrontal cortex of both stressed and control animals in parallel with the sucrose intake. Next, the animals showed decreased sucrose consumption were exposed to five further weeks of CMS and treated with the antidepressants imipramine or agomelatine, or the antipsychotic lurasidone. Our results demonstrate that only the stressed animals that were characterized by a deficit in sucrose intake showed increased expression of the pro-inflammatory cytokines IL-1β, IL-6 and up-regulation of markers and mediators of microglia activation such as CD11b, CX3CL1 and its receptor CX3CR1 in comparison with stress-resilient animals. Some of these molecular alterations persisted also after longer stress exposure and were modulated, similarly to the behavioral effects of CMS, by chronic pharmacological treatment. These data suggest that neuroinflammation may have a key role in the pathological consequences of stress exposure, thus contributing to the subject's vulnerability for depression
supplementary – Supplemental material for Effect of lurasidone treatment on chronic mild stress-induced behavioural deficits in male rats: The potential role for glucocorticoid receptor signalling
No full textSupplemental material, supplementary for Effect of lurasidone treatment on chronic mild stress-induced behavioural deficits in male rats: The potential role for glucocorticoid receptor signalling by Francesca Calabrese, Paola Brivio, Giulia Sbrini, Piotr Gruca, Magdalena Lason, Ewa Litwa, Monika Niemczyk, Mariusz Papp and Marco A Riva in Journal of Psychopharmacology</p
Six-month leuprorelin acetate depot formulations in advanced prostate cancer: a clinical evaluation
No full textUlf W Tunn,1 Damian Gruca,2 Peter Bacher3 1Urological Department, Prostate Center, Offenbach, Germany; 2AbbVie Deutschland GmbH and Co, KG, Ludwigshafen, Germany; 3AbbVie, North Chicago, IL, USA Abstract: For nearly three decades, gonadotropin-releasing hormone (GnRH) agonists, particularly leuprorelin acetate (LA), have served as an important part of the treatment armamentarium for prostate cancer. The introduction of LA depot formulations provided a significant improvement in the acceptance of this therapy; however, their indicated treatment duration of 1 to 4 months was still not long enough to satisfy all medical needs. For this reason some manufacturers developed new injectable formulations that provide testosterone suppression for 6 months. This review article assesses key publications in order to compare these long-acting, commercially available, LA depot formulations and their clinical performance. The literature search identified 14 publications; by excluding reviews, duplications, and non-English articles, only three original papers describing clinical trial remained for review: two focused on microsphere-based LA formulations with either a 30 mg or 45 mg dose and one focused on a gel-based leuprorelin acetate with a 45 mg dose. All products were tested in individual clinical trials and have demonstrated their efficacy and safety. Keywords: androgen deprivation therapy, GnRH agonist, leuprorelin acetate, prostate cancer, leuprolide acetat
Inter-Nord
No full textInter-Nord 24 is largely dedicated to Alaska. On the front and back covers feature three Yup’ik masks brought back to Pennsylvania by Moravian missionaries in the early 20th century. They are now held in the collections of the Moravian Historical Society in Nazareth, PA, USA, to which we are grateful for granting permission to publish these images. The front cover also includes a photograph from a series taken by Bruce Jackson during his field trip with Jean Malaurie to Nome and its region in 1997. Many thanks to Bruce for letting us reprint several of his images.
The issue’s contributions dedicated to Alaska include three peer-reviewed scientific articles, two student research papers from the University of Vienna based on field work, introduced by Peter Schweitzer and Olga Povoroznyuk, and two interviews: one with Iñupiaq contemporary artist Aisa Warden conducted by Daniel Chartier and the other with Mrs Lyn Trodahl Chynoweth, daughter of a Moravian missionary who grew up at Nunapitsinghak, site of the Moravian Children’s Home on the Kwethluk, a tributary to the Kuskokwim river, conducted by Benjamin Ferguson, as well as polar readings offered by Muriel Brot.
Inter-Nord 24 also pays homage to British poet and anthropologist Tom Lowenstein who passed away in March 2025 in his 84th year. Tom was notably the author of the acclaimed volume Ancient Land: Sacred Whale (1993, republished 1999). We are grateful to his literary executors to have authorised us to republish two longer excerpts, accompanied by translations into French for which we would like to sincerely thank Professor Hélène Aji of the École normale supérieure in Paris. Hélène had translated these poems on the occasion of the international conference “Problèmes arctiques : environnement, sociétés et patrimoine/ Arctic problems: environment, societies and heritage” organised by Jean Malaurie and myself at the National Museum of Natural History in Paris in March 2007 during the Fourth International Polar Year. Tom was one of the invited speakers, contributing a paper about his then forthcoming history of Point Hope, Alaska, Ultimate Americans (University of Alaska Press, 2008) published in Inter-Nord 21 (2011, pp. 149-152). Tom has published a fascinating volume about his field work, The Structure of Days Out (2021) which has not received the attention it deserves so far. Farewell to the poet!
Inter-Nord 24 also features three other peer-reviewed scientific articles in the section entitled “Varia”, illustrating the fact that we are open to scientific papers on any topic in relation to the Arctic. It also contains a viewpoint. Many thanks to all contributors
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