617 research outputs found
Dynamic model of an electro-hydraulic three point hitch
No full textThis paper proposes a dynamic model of an electro-hydraulic three point hitch for farm tractors. The modeling technique is based on the Hamiltonian system framework and on power-port interaction between subsystems. The model allows fast and precise simulations and therefore can be used for the development and the validation of control strategies by simulations and hardware in the loop experiments. The proposed model has been validated comparing the simulation results with experimental measurements. © 2006 IEEE
Modelling and simulation of static and Coulomb friction in a class of automotive systems
No full textStatic and Coulomb frictions are extensively used in automotive mechanical systems to control the synchronization between two shafts or two axles. Clutches, gearboxes and limited-slip differentials are some examples. This paper proposes a method for the efficient simulation of a wide class of automotive mechanical systems with static and Coulomb friction phenomena. The modelling approach is based on the port-Hamiltonian representation of the dynamic systems and the computation of the friction forces requires only the zero crossing detection. A slight approximation allows faster and sufficiently accurate simulations even without an accurate zero crossing detection. The proposed approach has been used to simulate the behaviour of a complex gearbox provided by some high level farm tractors
Supplemental Material - Spouses’ Health: What Happens Beyond the Widowhood Effect?
No full textSupplemental Material for Spouses’ Health: What Happens Beyond the Widowhood Effect? by Elisabetta Listorti, Margherita Silan, Elisa Ferracin, Mirko Di Martino, and Giuseppe Costa in Journal of Family Issues</p
Experimental current-voltage characteristics of Bi2223/Ag tapes and BSCCO current leads
No full textThe paper presents and analyses several tests aimed at representing the electrical characteristics of a sample of commercial Bi2223/Ag tapes (length: ∼ 1.1m) and of a cave cylindrical sample of pure BSCCO, in zero applied magnetic field. A typical hysteresis phenomenon has been observed at temperature below 120 K
MicroRNAs: toward the clinic for breast cancer patients
No full textExpression of microRNAs (miRNAs) has been found to be deregulated in all human cancers, where they may behave either as oncogenes or as tumor-suppressor genes. In the last 5 years, miRNA investigations in breast cancer represented an exciting area of discovery, which produced new knowledge on the molecular basis of this disease, tools for molecular classification, and new markers with diagnostic and prognostic relevance, as well as the discovery of novel breast cancer-predisposing genes. In this review, we describe current knowledge of the role of microRNAs in breast cancer
Boccaccio nella Biblioteca dell'Eloquenza Italiana di Giusto Fontanini
No full textIl contributo delinea la figura controversa di Giusto Fontanini (1666-1736), dei suoi difficili rapporti con Ludovico Antonio Muratori, della sua Biblioteca dell’eloquenza italiana uscita nel 1706 e poi in revisioni successive. Lo studio include l’edizione del 1753, fitta di annotazioni, aggiustamenti e integrazioni di Apostolo Zeno. Sul bibliografico e filologico sono messe in rilievo gli apporti delle opere del Boccaccio. In particolare è preso in esame un passo corrotto dell’Amorosa Visione nel testo critico di Vittore Branca (vv. 82-84, p. 182). Il luogo riguarda Ezzelino e l’attributo di Signore di Honara/Navarra. Il Fontanini avverte con lucidità il problema delle oscillazione della tradizione dei nomi propri in Boccaccio. L’erudito ha inoltre piena consapevolezza del valore degli studi del Salviati e del Borghini sul Decameron. D’altra parte, però, mostra un limite nell’eccessiva inclinazione verso pregiudizi moralistici nella interpretazione del capolavoro del Boccaccio
Social inequalities in heat-attributable mortality in the city of Turin, northwest of Italy: a time series analysis from 1982 to 2018
No full textBackground: Understanding context specific heat-health risks in urban areas is important, especially given anticipated severe increases in summer temperatures due to climate change effects. We investigate social inequalities in the association between daily temperatures and mortality in summer in the city of Turin for the period 1982–2018 among different social and demographic groups such as sex, age, educational level, marital status and household occupants. Methods: Mortality data are represented by individual all-cause mortality counts for the summer months between 1982 and 2018. Socioeconomic level and daily mean temperature were assigned to each deceased. A time series Poisson regression with distributed lag non-linear models was fitted to capture the complex nonlinear dependency between daily mortality and temperature in summer. The mortality risk due to heat is represented by the Relative Risk (RR) at the 99th percentile of daily summer temperatures for each population subgroup. Results: All-cause mortality risk is higher among women (1.88; 95% CI = 1.77, 2.00) and the elderly (2.13; 95% CI = 1.94, 2.33). With regard to education, the highest significant effects for men is observed among higher education levels (1.66; 95% CI = 1.38, 1.99), while risks for women is higher for the lower educational level (1.93; 95% CI = 1.79, 2.08). Results on marital status highlighted a stronger association for widower in men (1.66; 95% CI = 1.38, 2.00) and for separated and divorced in women (2.11; 95% CI = 1.51, 2.94). The risk ratio of household occupants reveals a stronger association for men who lived alone (1.61; 95% CI = 1.39, 1.86), while for women results are almost equivalent between alone and not alone groups. Conclusions: The associations between heat and mortality is unequal across different aspects of social vulnerability, and, inter alia, factors influencing the population vulnerability to temperatures can be related to demographic, social, and economic aspects. A number of issues are identified and recommendations for the prioritisation of further research are provided. A better knowledge of these effect modifiers is needed to identify the axes of social inequality across the most vulnerable population sub-groups
Supplementary_Figure_1 – Supplemental material for KRAS and ERBB-family genetic alterations affect response to PD-1 inhibitors in metastatic nonsquamous NSCLC
No full textSupplemental material, Supplementary_Figure_1 for KRAS and ERBB-family genetic alterations affect response to PD-1 inhibitors in metastatic nonsquamous NSCLC by Marika Cinausero, Noemi Laprovitera, Giovanna De Maglio, Lorenzo Gerratana, Mattia Riefolo, Marianna Macerelli, Michelangelo Fiorentino, Elisa Porcellini, Vanessa Buoro, Francesco Gelsomino, Anna Squadrilli, Gianpiero Fasola, Massimo Negrini, Marcello Tiseo, Manuela Ferracin and Andrea Ardizzoni in Therapeutic Advances in Medical Oncology</p
Supplementary_table_1 – Supplemental material for KRAS and ERBB-family genetic alterations affect response to PD-1 inhibitors in metastatic nonsquamous NSCLC
No full textSupplemental material, Supplementary_table_1 for KRAS and ERBB-family genetic alterations affect response to PD-1 inhibitors in metastatic nonsquamous NSCLC by Marika Cinausero, Noemi Laprovitera, Giovanna De Maglio, Lorenzo Gerratana, Mattia Riefolo, Marianna Macerelli, Michelangelo Fiorentino, Elisa Porcellini, Vanessa Buoro, Francesco Gelsomino, Anna Squadrilli, Gianpiero Fasola, Massimo Negrini, Marcello Tiseo, Manuela Ferracin and Andrea Ardizzoni in Therapeutic Advances in Medical Oncology</p
MicroRNA expression changes during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal, a product of lipid peroxidation
No full text4-Hydroxynonenal (HNE) is one of several lipid oxidation products that may have an impact on human pathophysiology. It is an important second messenger involved in the regulation of various cellular processes and exhibits antiproliferative and differentiative properties in various tumor cell lines. The mechanisms by which HNE affects cell growth and differentiation are only partially clarified. Because microRNAs (miRNAs) have the ability to regulate several cellular processes, we hypothesized that HNE, in addition to other mechanisms, could affect miRNA expression. Here, we present the results of a genome-wide miRNA expression profiling of HNE-treated HL-60 leukemic cells. Among 470 human miRNAs, 10 were found to be differentially expressed between control and HNE-treated cells (at p<0.05). Six miRNAs were down-regulated (miR-181a*, miR-199b, miR-202, miR-378, miR-454-3p, miR-575) and 4 were up-regulated (miR-125a, miR-339, miR-663, miR-660). Three of these regulated miRNAs (miR-202, miR-339, miR-378) were further assayed and validated by quantitative real-time RT-PCR. Moreover, consistent with the down-regulation of miR-378, HNE also induced the expression of the SUFU protein, a tumor suppressor recently identified as a target of miR-378. The finding that HNE could regulate the expression of miRNAs and their targets opens new perspectives on the understanding of HNE-controlled pathways. A functional analysis of 191 putative gene targets of miRNAs modulated by HNE is discussed
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