1,998 research outputs found
OConnorOpenPracticesDisclosure – Supplemental material for Do Evaluations Rise With Experience?
No full textSupplemental material, OConnorOpenPracticesDisclosure for Do Evaluations Rise With Experience? by Kieran O’Connor and Amar Cheema in Psychological Science</p
Supplemental Material, Web_Appendices_-_Updated - The Effect of Student Loan Debt on Spending: The Role of Repayment Format
No full textSupplemental Material, Web_Appendices_-_Updated for The Effect of Student Loan Debt on Spending: The Role of Repayment Format by Yi Zhang, Ronald T. Wilcox and Amar Cheema in Journal of Public Policy & Marketing</p
Supplemental Material, jm.16.0391-File003 - Path to Purpose? How Online Customer Journeys Differ for Hedonic Versus Utilitarian Purchases
No full textSupplemental Material, jm.16.0391-File003 for Path to Purpose? How Online Customer Journeys Differ for Hedonic Versus Utilitarian Purchases by Jingjing Li, Ahmed Abbasi, Amar Cheema and Linda B. Abraham in Journal of Marketing</p
sj-pdf-1-cep-10.1177_03331024231168089 - Supplemental material for New daily persistent headache: A systematic review and meta-analysis
No full textSupplemental material, sj-pdf-1-cep-10.1177_03331024231168089 for New daily persistent headache: A systematic review and meta-analysis by Sanjay Cheema, Dwij Mehta, Jason Charles Ray, Elspeth J Hutton and Manjit Singh Matharu in Cephalalgia</p
An occasional diagnosis of myasthenia gravis - a focus on thymus during cardiac surgery: a case report
No full textAbstract Background Myasthenia gravis, an uncommon autoimmune syndrome, is commonly associated with thymus abnormalities. Thymomatous myasthenia gravis is considered to have worst prognosis and thymectomy can reverse symptoms if precociously performed. Case report We describe a case of a patient who underwent mitral valve repair and was found to have an occasional thymomatous mass during the surgery. A total thymectomy was performed concomitantly to the mitral valve repair. Conclusion The diagnosis of thymomatous myasthenia gravis was confirmed postoperatively. Following the surgery this patient was strictly monitored and at 1-year follow-up a complete stable remission had been successfully achieved.</p
sj-pdf-2-cep-10.1177_03331024231168089 - Supplemental material for New daily persistent headache: A systematic review and meta-analysis
No full textSupplemental material, sj-pdf-2-cep-10.1177_03331024231168089 for New daily persistent headache: A systematic review and meta-analysis by Sanjay Cheema, Dwij Mehta, Jason Charles Ray, Elspeth J Hutton and Manjit Singh Matharu in Cephalalgia</p
Multiple Long-Term Conditions (MLTC) and the Environment: A Scoping Review
No full textBackground: Multiple Long Term conditions (MLTC) are a major health care challenge associated with high service utilisation and expenditure. Once established, the trajectory to an increased number and severity of conditions, hospital admission, increased social care need and mortality is multifactorial. The role of wider environmental determinants in the MLTC sequelae is unclear. Aim: the aim of this review was to summarise and collate existing evidence on environmental determinants on established MLTC. Methods: comprehensive search of Medline, Embase, Cochrane, CINAHL and Bielefeld Academic Search Engine (BASE), from inception to 4th June 2022 in addition to grey literature. Two authors independently screened and extracted papers. Disagreements were resolved with a third author. Results: searches yielded 9079 articles, 12 of which met the review’s inclusion criteria. Evidence of correlations between some environmental determinants and increased or decreased risks of MLTC were found, including the quality of internal housing/living environments, exposure to airborne environmental hazards and a beneficial association with socially cohesive, accessible and greener neighbourhood environments. Conclusions: The majority of the 12 included papers focused on the built and social environments. The review uncovered very limited evidence, indicating a need for further research to understand the role of environmental determinants in MLTC
Pulmonary rehabilitation (PR) exercise tolerance improvement: differences between interstitial lung disease (ILD) and chronic obstructive pulmonary disease (COPD)
No full textBackground: there is evidence to suggest that PR is beneficial for patients with chronic lung diseases other than COPD (ATS/ERS Statement on Pulmonary Rehabilitation 2006, National Institute for Health and Clinical Excellence Interstitial Lung Disease consultation document 2013). However, there is little evidence regarding the magnitude of improvement in patients with ILD relative to those with COPD.Aim: to determine whether exercise tolerance improvement following PR differs significantly between ILD and COPD patients who participate in the same PR programmes.Method: retrospective exercise tolerance test (Endurance Shuttle Walk Test (ESWT)) data for all patients completing our 3 site PR programme from February 2005 to December 2012 were analysed. Practice walks were performed. Results were compared between the ILD and COPD patients using independent sample two-tailed t-tests on data for pre-PR ESWT, post-PR ESWT and ESWT change.Results: of 495 patients with complete data, 55 had ILD and 440 COPD. Both groups had large improvements, with no significant differences between group ESWT pre PR (t= -0.049, p=0.961), post PR (t= -0.227, p=0.820) or change in ESWT (t= -0.228, p=0.820).Conclusions: these data suggest that patients with ILD gain equal benefit in exercise tolerance from PR to patients with COPD. ILD patients with a reduced exercise tolerance should be included and referred for PR
Patents and heart valve surgery - I : mechanical valves
No full textValvular heart disease, inherited or acquired, affects more than 5 million Americans yearly. Whereas medical treatment is beneficial in the initial stages of valvular heart disease, surgical correction provides symptomatic relief and long-term survival benefits. Surgical options include either repair or replacement using mechanical or bio-prosthetic valves. Patient age and the post-operative need for anticoagulation therapy are major determinants of the choice between use of mechanical or bio-prosthetic valves. Since the first mechanical valves were made available several decades ago, the incorporation of increasingly sophisticated materials and methodologies has led to substantial improvements in the valve design, and has catalyzed a parallel increase in the amount of patents issued for these emerging technologies. In this paper, we have chronologically reviewed such patents, briefly discussed various challenges that mechanical heart valve implementation is faced with and finally reviewed some of the strategies employed to overcome such obstacles. An ideal prosthetic heart valve would comprehensively mimic the natural hemodynamics and physiology of the native heart valve. Additionally, such a valve would be easily implantable, associated with a minimal risk of thrombosis and thus need for anti-coagulation, and with a proven long-term durability. With cutting edge technological advancements in the recent times, the ongoing innovative and collaborative efforts of physicians, scientists, and engineers will not seize until an ideal mechanical heart valve becomes a reality
Resveratrol, a natural red wine polyphenol, reduces ischemia-reperfusion-induced spinal cord injury.
No full textBACKGROUND: Severe neurologic injury still represents one of the most devastating complications after surgical repair of thoracoabdominal aneurysms. We therefore aimed to investigate the protective effect of resveratrol, a natural polyphenol antioxidant present in grapes and wine, in an experimental model of spinal cord ischemia-reperfusion injury.
METHODS: Sixteen rabbits were assigned either to group A (n = 8; receiving resveratrol, treated group) or group B (n = 8; control group, nontreated group) and underwent a 30-minutes period of spinal cord ischemia by clamping the abdominal aorta between the left renal artery and the aortic bifurcation. Fifteen minutes before clamping, rabbits received either intravenous resveratrol (100 microg/kg; group A) or normal saline (group B). Functional assessment with Tarlov score at 8, 16, and 24 hours postoperatively, histopathologic assessment of the spinal cord, measurements of malondialdehyde levels, and myeloperoxidase activity in the spinal cord were performed.
RESULTS: Neurologic impairment (Tavlov score for group A = 4.38 +/- 1.19 and for group B = 0.38 +/- 0.74, p < 0.001), malondialdehyde levels (47.71 +/- 7.81 nmol/g versus 86.56 +/- 11.39 nmol/g, p < 0.001), and myeloperoxidase activity (2.13 +/- 0.72 nm/min versus 3.75 +/- 0.78 nm/min, p = 0.002) were significantly lower in the resveratrol-treated animals. Additionally, pathologically assessed outcomes were better in the resveratrol-treated group. The total number of motor neurons in the gray matter was significantly lower in the nontreated group than in the resveratrol-treated group (14.26 +/- 2.94 versus 29.12 +/- 3.64, p = 0.003).
CONCLUSIONS: Prophylactic use of resveratrol reduced neurologic injury and provided clinical improvement by attenuating the inflammatory milieu in the rabbit spinal cord ischemia/reperfusion model
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