400 research outputs found
Hans Bots et Françoise Waquet, La République des Lettres
No full textCallard Caroline. Hans Bots et Françoise Waquet, La République des Lettres. In: Histoire, économie et société, 1998, 17ᵉ année, n°2. p. 327
Teaching the Gifted in an Inclusion Classroom : Activities That Work
No full textBy Rosemary S. Callard-Szulgit. This book is jam-packed with successful, field-tested activities that have both excited and worked for children at all education levels. This book offers educators and parents the best of all worlds - educational activities and competitions not just for the gifted child, but for all children. --Book jacket.As our educational system extends its resources and efforts to help make schools and classrooms more accessible to handicapped and special education students, teachers are finding themselves overwhelmed with increased demands, overcrowding, and lack of adequate training in managing all the necessary demands of an inclusion classroom. Inadvertently, instructional time and resources are often taken away from our gifted children. Jam-packed with very successful ideas and activities that the author has used in her 37 years of teaching gifted students, this resource guide contains field-tested activities that have excited and worked for all educational levels. It offers educators and parents the best of all worlds, containing educational activities and competitions not just for the gifted child, but for all children.Dr. Callard-Szulgit has a staff development consulting business, Partners for Excellence (www.partners-for-excellence.com), in Rochester, NY and Phoenix, AZ. She is the former facilitator for Gifted and Talented, K-8, in the Webster Central School District, a suburb of Rochester, NY and she continues to have articles published dealing with the education of gifted children.https://digitalcommons.brockport.edu/bookshelf/1133/thumbnail.jp
sj-zip-1-csp-10.1177_02610183211024820 – Supplemental material for Mapping mental health and the UK university sector: Networks, markets, data
No full textSupplemental material, sj-zip-1-csp-10.1177_02610183211024820 for Mapping mental health and the UK university sector: Networks, markets, data by Dimitra Kotouza, Felicity Callard, Philip Garnett and Leon Rocha in Critical Social Policy</p
Therapeutic hypothermia protocol for a limited resource setting - an evidence-based practice guideline
No full textThis poster is a summary of an evidence-based practice guideline, produced by Beatrix Callard, in partial fulfilment of a Master of Nursing in Child Nursing degree, in 2018. For more details/the full guideline, please contact The Children’s Nursing Development Unit at [email protected] re use: This guideline is recommended for use for five years from the date of the student’s course completion (2018). Beyond the five-year period, the CNDU advise that the guideline be updated by prospective users before implementation in clinical settings. Where possible, revisions should be made in consultation with the author. Changes should be accompanied by a note in the footer that reads: “Revised [date] by [name/s]: [brief summary of change made – e.g., oxygen flow rates revised to reflect WHO recommendation].”</p
The adoption, local implementation and assimilation into routine practice of a national quality improvement programme: the productive ward in England
No full textAim and objective. To explore why innovations in service and delivery are adopted and how they are then successfully implemented and eventually assimilated into routine nursing practice.Background. The ‘Productive Ward’ is a national quality improvement programme that aims to engage nursing staff in the implementation of change at ward level.Design. Mixed methods (analysis of routine data, online survey, interviews) to apply an evidence-based diffusion of innovations framework.Method. (1) Broad and narrow indicators of the timing of ‘decisions to adopt’ the Productive Ward were applied. (2) An online survey explored the perceptions of 150 respondents involved with local implementation. (3) Fifty-eight interviews in five organisational case studies to explore the process of assimilation in each context.Results. Since the launch of the programme in May 2008 staff in approximately 85% of NHS acute hospitals had either downloaded Productive Ward materials or formally purchased a support package (as of March 2009). On a narrower measure, 40% (140) of all NHS hospitals had adopted the programme (i.e. purchased a support package) with large variation between geographical regions. Four key interactions in the diffusion of innovations framework appeared central to the rapid adoption of the programme. Despite widespread perception of significant benefits, frontline nursing staff report that more needs to be carried out to ensure that impact can be demonstrated in quantifiable terms and include patient perspectives.Conclusions. The programme has been rapidly adopted by NHS hospitals in England. A variety of implementation approaches are being employed, which are likely to have implications for the successful assimilation of the programme into routine nursing practice.Relevance to clinical practice. This paper summarises the perceived benefits of the Productive Ward programme and highlights important lessons for nurse leaders who are designing (or adapting) and then implementing quality improvement programmes locally, particularly in terms of how to frame such initiatives – and provide support to – ward-level staff
Correction of scaling mismatches in oligonucleotide microarray data
No full textBackground: Gene expression microarray data is notoriously subject to high signal variability. Moreover, unavoidable variation in the concentration of transcripts applied to microarrays may result in poor scaling of the summarized data which can hamper analytical interpretations. This is especially relevant in a systems biology context, where systematic biases in the signals of particular genes can have severe effects on subsequent analyses. Conventionally it would be necessary to replace the mismatched arrays, but individual time points cannot be rerun and inserted because of experimental variability. It would therefore be necessary to repeat the whole time series experiment, which is both impractical and expensive. Results: We explain how scaling mismatches occur in data summarized by the popular MAS5 (GCOS; Affymetrix) algorithm, and propose a simple recursive algorithm to correct them. Its principle is to identify a set of constant genes and to use this set to rescale the microarray signals. We study the properties of the algorithm using artificially generated data and apply it to experimental data. We show that the set of constant genes it generates can be used to rescale data from other experiments, provided that the underlying system is similar to the original. We also demonstrate, using a simple example, that the method can successfully correct existing imbalancesin the data. Conclusion: The set of constant genes obtained for a given experiment can be applied to other experiments, provided the systems studied are sufficiently similar. This type of rescaling is especially relevant in systems biology applications using microarray data. © 2006 Barenco et al; licensee BioMed Central Ltd
Between legislation and bioethics: the European Convention on Human Rights and Biomedicine
No full textThe chapter explores the role that regional legislation plays in framing human rights and ethical principles in psychiatry by considering the Council of Europe’s Convention on Human Rights and Biomedicine. The chapter identifies the Convention’s contribution to an emergent legislative, regulatory and discursive formation, which is characterized by its alloy of human rights and bioethics. The author draws attention to articles within the Convention that have implications for psychiatry as regards its engagement with patients, with those on whom it depends to conduct research, and with the public. As well as indicating how various States within the Council of Europe have responded to the Convention, the author considers how the Convention attempts to align human rights and ethics through the regulation and formalisation of the relationship between doctor and patient, and researcher and research participant. This alignment is taking place at the same time as biomedicine is putting pressure on concepts (such as autonomy and informed consent) central to bioethics and human rights discourse
Psychiatric diagnosis: the indispensability of ambivalence
No full textThe author analyses how debate over the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders has tended to privilege certain conceptions of psychiatric diagnosis over others, as well as to polarise positions regarding psychiatric diagnosis. The article aims to muddy the black and white tenor of many discussions regarding psychiatric diagnosis by moving away from the preoccupation with diagnosis as classification and refocusing attention on diagnosis as a temporally and spatially complex, as well as highly mediated process. The article draws on historical, sociological and first-person perspectives regarding psychiatric diagnosis in order to emphasise the conceptual—and potentially ethical—benefits of ambivalence vis-à-vis the achievements and problems of psychiatric diagnosis
Why the Patient-Made Term 'Long Covid' is needed
No full textThe patient-made term ‘Long Covid’ is, we argue, a helpful and capacious term that is needed to address key medical, epidemiological and socio-political challenges posed by diverse symptoms persisting beyond four weeks after symptom onset suggestive of coronavirus disease 2019 (COVID-19). An international movement of patients (which includes all six authors) brought the persistence and heterogeneity of long-term symptoms to widespread visibility. The same grassroots movement introduced the term ‘Long Covid’ (and the cognate term ‘long-haulers’) to intervene in relation to widespread assumptions about disease severity and duration. Persistent symptoms following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are now one of the most pressing clinical and public health phenomena to address: their cause(s) is/are unknown, their effects can be debilitating, and the percentage of patients affected is unclear, though likely significant. The term ‘Long Covid’ is now used in scientific literature, the media, and in interactions with the WHO. Uncertainty regarding its value and meaning, however, remains. In this Open Letter, we explain the advantages of the term ‘Long Covid’ and bring clarity to some pressing issues of use and definition. We also point to the importance of centring patient experience and expertise in relation to ‘Long Covid’ research, as well as the provision of care and rehabilitation.</ns4:p
Epicutaneous immunization with type II collagen inhibits both onset and progression of chronic collagen-induced arthritis.
No full textEpicutaneous immunization is a potential non-invasive technique for antigen-specific immune-modulation. Topical application of protein antigens to barrier-disrupted skin induces potent antigen-specific immunity with a strong Th2-bias. In this study, we investigate whether the autoimmune inflammatory response of chronic collagen-induced arthritis (CCIA) in DBA/1-TCR-beta Tg mice can be modified by epicutaneous immunization. We show that epicutaneous immunization with type II collagen (CII) inhibited development and progression of CCIA and, importantly, also ameliorated ongoing disease as indicated by clinical scores of disease severity, paw swelling and joints histology. Treated mice show reduced CII-driven T cell proliferation and IFN-gamma production, as well as significantly lower levels of CII-specific IgG2a serum antibodies. In contrast, CII-driven IL-4 production and IgE antibody levels were increased consistent with skewing of the CII response from Th1 to Th2 in treated mice. IL-4 production in treated mice was inversely correlated with disease severity. Moreover, T cells from treated mice inhibited proliferation and IFN-gamma production by T cells from CCIA mice, suggesting induction of regulatory T cells that actively inhibit effector responses in arthritic mice. The levels of CD4(+)CD25(+) T cells were however not increased following epicutaneous CII treatment. Together, these results suggest that epicutaneous immunization may be used as an immune-modulating procedure to actively re-programme pathogenic Th1 responses, and could have potential as a novel specific and simple treatment for chronic autoimmune inflammatory diseases such as rheumatoid arthritis
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