467 research outputs found
Chemical graph theory
No full textThis chapter on chemical graph theory forms part of the natural science and processes section of the handboo
The monetary circulation of Moesia Inferior from the beginning of the 2nd century AD to the end of the 3rd century AD
No full textThis thesis intends to gather and analyse all coin hoards and the majority of the single finds found on the territory of Moesia Inferior, dated between AD 100 and 300. The study will demonstrate how coins, through their existence as archaeological objects, offer profound insights not only into the matters of economy, state organization, and monetary supply but also into the local history of the cities which operated as mints. This study attempts to build a new and detailed framework for studying and interpreting coin assemblages in this area of Europe. A major aim is to create a fundamental basis for future research in the province so every new hoard or stray find can be added to the database which will allow large-scale analysis; this database will facilitate the incorporation of Lower Moesia into the numismatic map of the Roman Empire.</p
A survey of current software for network analysis in molecular biology
No full textAbstract Software for network motifs and modules is briefly reviewed, along with programs for network comparison. The three major software packages for network analysis, CYTOSCAPE, INGENUITY and PATHWAY STUDIO, and their associated databases, are compared in detail. A comparative test evaluated how these software packages perform the search for key terms and the creation of network from those terms and from experimental expression data.</p
Network Topology Analysis of Post-Mortem Brain Microarrays Identifies More Alzheimer's Related Genes and MicroRNAs and Points to Novel Routes for Fighting with the Disease.
No full textNetwork-based approaches are powerful and beneficial tools to study complex systems in their entirety, elucidating the essential factors that turn the multitude of individual elements into a functional system. In this study we used critical network topology descriptors and guilt-by-association rule to explore and understand the significant molecular players, drug targets and underlying biological mechanisms of Alzheimer's disease. Analyzing two post-mortem brain gene microarrays (GSE4757 and GSE28146) with Pathway Studio software package we constructed and analyzed a set of protein-protein interaction, as well as miRNA-target networks. In a 4-step procedure the expression datasets were normalized using Robust Multi-array Average approach, while the modulation of gene expression by the disease was statistically evaluated by the empirical Bayes method from the limma Bioconductor package. Representative set of 214 seed-genes (p<0.01) common for the three brain sections of the two microarrays was thus created. The Pathway Studio analysis of the networks built identified 15 new potential AD-related genes and 17 novel AD-involved microRNAs. Using KEGG pathways relevant in Alzheimer's disease we built an integrated mechanistic network from the interactions between the overlapping genes in these pathways. Routes of possible disease initiation process were thus revealed through the CD4, DCN, and IL8 extracellular ligands. DAVID and IPA enrichment analysis uncovered a number of deregulated biological processes and pathways including neuron projection/differentiation, aging, oxidative stress, chemokine/ neurotrophin signaling, long-term potentiation and others. The findings in this study offer information of interest for subsequent experimental studies
Georgi Bonchev's paper "Contribution to the springs in Bulgaria", 1939, and its significance for hydrogeology in Bulgaria
No full textIn 1939, one of the first summarizing works of the famous Bulgarian geologist Georgi Bonchev “Contribution to the springs in Bulgaria” related to groundwater in the country was published. In his field research, the author visited and described about 60 natural springs or groups of springs with temperatures from 20 °C to over 75 °C, attached to different tectonic zones, over 40 lukewarm and cold springs with mineralized waters and about 290 karst and other cold springs. This article is also relevant for modern hydrogeology. The presented general picture of the locations of the springs, the discharge and qualities of the waters from the natural springs before 1939 allows making comparisons of the occurred changes due to natural and anthropogenic factors
Alzheimer’s disease <i>direct interaction</i> network.
No full text<p>The 15 genes/proteins implicated in AD pathology are highlighted in green and the two genes/proteins of potential interest for that disease are highlighted in blue.</p
Effect of semen extenders on sperm motion of in vitro stored muscovy drake spermatozoa
No full textA study for the influence of semen extenders IMV-buffer, HIA- 1 and AU on
sperm motion characteristics of Muscovy drake spermatozoa was carried out.
The semen from each male (n=6) was divided into three equal parts and diluted
in ratio 1:3 (semen:extender) with the IMV-buffer, HIA-1 and AU respectively,
and then was stored at temperature 0-4C? for 6 hours. Sperm motion parameters
- velocity of spermatozoa (rapid, medium, slow and statistic), VCL, VSL, VAP,
LIN, STR, WOB were measured using a Sperm Class Analizer (Micropticum,
Spain). Computer-assisted sperm motion analysis indicated that Muscovy
spermatozoa preserved a rapid and medium sperm velocity after 6 hours in
vitro storage in three examination extenders. The total VCL, VSL and VAP of
spermatozoa in the semen diluted with AU extender were 110.47?7.44 ?m/s,
29.42?2.02 ?m/s and 57.39?3.73 ?m/s, in the semen diluted with IMV-buffer
were 94.93?11.10 ?m/s, 27.57?2.45 ?m/s and 51.35?4.98 ?m/s, and in the semen
diluted with HIA-1 were 68.48?12.74 ?m/s, 20.08?4.18 ?m/s and 37.75?7.65
?m/s, as the differences were significant between AU and HIA-1 - (P<0.05).
About LIN, STR, WOB there were no significant differences for the influence
of the extenders.</jats:p
Alzheimer’s disease <i>miRNA</i> regulatory network.
No full text<p>The genes/proteins and miRNAs implicated in AD pathology are highlighted in green and the genes/proteins of potential interest are highlighted in blue. Genes/proteins that code for transcription factors (TFs) are highlighted in yellow.</p
Four-set Venn diagram of the overlap of significantly differentially expressed genes (SDEGs) in GSE28146 gene expression datasets.
No full text<p>Courtesy: Oliveros, J.C. (2007–2015) Venny. An interactive tool for comparing lists with Venn's diagrams. Publicly available at <a href="http://bioinfogp.cnb.csic.es/tools/venny/index.html" target="_blank">http://bioinfogp.cnb.csic.es/tools/venny/index.html</a>.</p
Enriched KEGG pathways in Alzheimer’s disease resulted from DAVID analysis.
No full textEnriched KEGG pathways in Alzheimer’s disease resulted from DAVID analysis.</p
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