653 research outputs found
Carlo Bononi, Giovanni Francesco Barbieri detto il Guercino
No full textVengono presi in esame sette dipinti, per i quali vengono specificate l'autografia e la cronologia. In alcuni casi si tratta di opere riferite al Guercino per la prima volta dall'autore.Seven paintings are examined, for which the autograph and the chronology are specified. In some cases, these are works referring to Guercino for the first time by the author
Entre ombres et lumières : Giuseppe Maria Crespi et les peintres de la ligne néo-carrachesque
No full textIn occasione di una mostra sul Settecento bolognese tenuta al Musèe Fesch di Aiaccio nell'estate 2024, viene ripercorsa l'attività di Giuseppe Maria Crespi, individuando la sua importanza per una pittura di forte accento naturalista che prosegue la linea avviata dai Carracci. Accanto a dipinti già noti, vengono discussi quadri inediti sia di Crespi sia di altri artisti bolognesi
Per un primo bilancio sul Barocco negato
No full textIntervento introduttivo al convegno organizzato nel 2007 da D. Benati e R. Torlontano, dedicato al Barocco in Abruzzo. L'inervento ripercorre le vicende artistiche nel XVII e XVIII secolo, facendone emergere gli episodi salienti e richiamando aspetti meno noti, nell'intento di restituire al Barocco abruzzese l'importanza che gli è stata negata in passato, allorché i suoi principali monumenti sono stati cancellati per far posto a una restituzione unilaterale dell'arte medievale
scheda Nicolò Pisano
No full textA. Serrani, [SCHEDA NICOLÒ PISANO], in Giulio II e Raffaello. Una nuova stagione del Rinascimento a Bologna, a cura di D. Benati, M.L. Pacelli, E. Rossoni, catalogo della mostra (Bologna), Cinisello Balsamo, 2022, p. 161, n. VII.4
scheda Bagnacavallo
No full textA. Serrani, [SCHEDA BAGNACAVALLO], in Giulio II e Raffaello. Una nuova stagione del Rinascimento a Bologna, a cura di D. Benati, M.L. Pacelli, E. Rossoni, catalogo della mostra (Bologna), Cinisello Balsamo, 2022, p. 162, n. VII.8
scheda Sebastiano Serlio (?)
No full textA. Serrani, [SCHEDA SEBASTIANO SERLIO (?)], in Giulio II e Raffaello. Una nuova stagione del Rinascimento a Bologna, a cura di D. Benati, M.L. Pacelli, E. Rossoni, catalogo della mostra (Bologna), Cinisello Balsamo, 2022, p. 162, n. VII.7
scheda Onofri
No full textA. Serrani, [SCHEDA VINCENZO ONOFRI], in Giulio II e Raffaello. Una nuova stagione del Rinascimento a Bologna, a cura di D. Benati, M.L. Pacelli, E. Rossoni, catalogo della mostra (Bologna), Cinisello Balsamo, 2022, p. 72, n. II.4
Benati D (2016). Guido Reni, Giovanni Francesco Barbieri. In: (a cura di): Redìn Michaus G, De Caravaggio a Bernini. Pintura y escultura del Seicento en las Colecciones Reales de Patrimonio Nacional. p. 9-17, Madrid:Patrimonio Nacional, ISBN: 9788471205094
No full textVengono studiati due importanti dipinti di Guido Reni (La conversione di Saulo) e del Guercino (lot e le figlie), provenienti dalla collezione Ludovisi a Roma e ora nel Museo dell'Escorial a Madrid. Nell'occasione vengono approfonditi i rapporti del Guercino con Ludovico Carracci e di Reni con il Caravaggio
In cerca di Giovanni Francesco Crivelli
No full textA partire da un dipinto firmato, raffigurante la "Madonna col Bambino in trono e due angeli", l'articolo restituisce corpo alla problematica personalità del pittore Giovanni Francesco Crivelli, attivo in area adriatica a cavallo tra XV e XVI secolo. La ricerca sull'artista, avviata da Federico Zeri, si è incrementata grazie alle precisazioni recate dall'Autore.Starting with a signed painting depicting the "Madonna and Child Enthroned and Two Angels", the article gives body to the problematic personality of the painter Giovanni Francesco Crivelli, active in the Adriatic area at the turn of the fifteenth and sixteenth centuries. The research on the artist, started by Federico Zeri, has increased thanks to the clarifications brought by the author
Genetic and epigenetic alterations as serum markers for cancer detection
No full textSeveral studies have shown that epigenetic mechanisms, as microRNAs (miRs) expression and gene methylation are involved in cancer, by regulating cell proliferation, apoptosis and angiogenesis. Accordingly, epigenetic changes occur from early stages and accumulate during cancer progression, by contributing to cancer development and progression. The present work includes three papers presenting novel genetic and epigenetic changes that could contribute to the identification of new non-invasive cancer biomarkers. The aim of first work was to compare the status of KRAS mutation and SEPT9 methylation between the primary tumors and matched plasma samples in patients affected by colorectal cancer (CRC). KRAS mutations and SEPT9 promoter methylation were present in 34.1% (29/85) and in 95.3% (81/85) of the primary tumour tissue samples. Patients presented with both genetic and epigenetic alterations in tissue specimens (31.8%, 27/85) were considered for further analyses on cfDNA. The median methylation rate in tumour tissues and plasma samples was 64.5% (12.2–99.8%) and 14.5% (0–45.5%), respectively. The median KRAS mutation load (for matched mutations) was 33.6% (1.2- 86%) in tissues and 4% (0-17%) in plasma samples. A statistically significant correlation was found between tissue and plasma SEPT9 methylation rate (r=0.41, p=0.035), whereas no association was found between tissue and plasma KRAS mutation load (r=0.09, p=0.651). These data show a discrepancy in epigenetic versus genetic alterations detectable in cfDNA as markers for tumour detection. Many factors could affect the mutant cfDNA analysis including the sensitivity of the detection method and the presence of tumour clonal heterogeneity. The second line of research has focused on patients affected by epithelial ovarian cancer (EOC). Serum levels of miR-199a and miR-125b were found to be significantly higher in EOC patients compared to healthy controls (p=0.007 and p=0.002, respectively). A statistically significant correlation was found between miR-199a and miR-125b expression levels (r=0.38, p=0.03). The ROC curve analysis revealed that HE4 had a significantly higher area under the curve (AUC: 0.90) when compared to CA125 (AUC: 0.85), miR-199a (AUC: 0.70) and miR-125b (AUC: 0.67). Despite the low specificity, mainly in pre-menopausal women, CA125 and HE4 seem to have better diagnostic performance compared to miRs investigated in our study. The third line of research has focused on investigate in human endometrial cancer (EC) the expression of miR-186, miR-222, miR-223, miR-204. Serum levels of miR-186, miR-222 and miR-223 resulted significantly up-regulated in patients compared to healthy controls (p=0.004, p=0.002 and p<0.0001). Contrarily, miR-204 resulted significantly down-regulated in EC patients compared to healthy controls (p<0.0001). A positive significant correlation was observed between miR-186 and both miR-222 (r=0.71, p<0.0001) and miR-223 (r=0.64, p<0.0001) as well also between miR-222 and miR-223 (r=0.57, p<0.0001). The AUCs for the selected miRs ranged from 0.70 to 0.87, significantly higher than for CA125 (0.59). Our results confirm that these miRs are implicated in EC and hold promise as a novel blood-based biomarker for the diagnosis. In conclusion, our results indicate that circulating nucleic acids are a potentially promising source of tumor-specific biomarkers in patients affected by different solid cancer
- …
