2,125 research outputs found
New Models of Care and Innovation in Alzheimer’s Disease and Related Dementias
No full textDr. Anitha Rao delivered several presentations at the Alzheimer’s Association International Conference (AAIC) in London, UK, July 2017.1–3 In an expert interview following AAIC 2017, Dr. Rao discusses the current limitations of standard care for patients with Alzheimer’s disease and related dementias (ADRD), and puts into perspective the potential positive impact of important new technologies such as Neurocern.</p
Explorations on the Nature of Resistance: Challenging Gender Based Violence in the Academy
No full textGender based violence (GBV) in universities is well-established as a matter of concern in policy, political and academic environments in the US (e.g. Fisher, et al. 2010) and Canada (e.g. DeKeseredy and Schwartz 2011). In Europe and elsewhere, attention to it has developed more recently (Anitha and Lewis 2018). Hand in hand with that attention, comes resistance to all the forms of GBV, defined here as ‘behaviour or attitudes underpinned by inequitable power relations that hurt, threaten or undermine people because of their (perceived) gender or sexuality’ (Anitha and Lewis 2018, p. 1). This chapter explores the different kinds of resistance that are emerging, including attempts to eradicate GBV (by national bodies, higher education institutes, campaigning groups and activists) as well as the strategies of resistance by those whose actions can be characterised as comprising a ‘backlash’ to (perceived) feminist gains and an attempt to hold onto a gendered status quo.</p
Explorations on the Nature of Resistance: Challenging Gender Based Violence in the Academy
No full textGender based violence (GBV) in universities is well-established as a matter of concern in policy, political and academic environments in the US (e.g. Fisher, et al. 2010) and Canada (e.g. DeKeseredy and Schwartz 2011). In Europe and elsewhere, attention to it has developed more recently (Anitha and Lewis 2018). Hand in hand with that attention, comes resistance to all the forms of GBV, defined here as ‘behaviour or attitudes underpinned by inequitable power relations that hurt, threaten or undermine people because of their (perceived) gender or sexuality’ (Anitha and Lewis 2018, p. 1). This chapter explores the different kinds of resistance that are emerging, including attempts to eradicate GBV (by national bodies, higher education institutes, campaigning groups and activists) as well as the strategies of resistance by those whose actions can be characterised as comprising a ‘backlash’ to (perceived) feminist gains and an attempt to hold onto a gendered status quo.</p
Bridging the gap between business and technology : Bumiputra-Commerce's approach / Anitha a/p Poopalasingam
No full textPEGylating poly(p-phenylene vinylene)-based bioimaging nanoprobes
No full textHypothesis: Conjugated polymer nanoparticles (CNPs) have attracted considerable attention within bioimaging due to their excellent optical properties and biocompatibility. However, unspecific adsorption of proteins hampers their effective use as advanced bioimaging probes. Controlled methodologies made possible tailor-made functional poly(p-phenylene vinylene), enabling one-pot synthesis of CNPs containing functional surface groups. Hence, it should be feasible to PEGylate these CNPs to tune the uptake by cell lines representative for the brain without imparting their optical properties. Experiments: CNPs consisting of the statistical copolymer 2-(50-methoxycarbonylpentyloxy)-5-methoxy-1,4-phenylenevinylene and poly(2-methoxy-5-(30,70-dimethoxyoctyloxy)-1,4-phenylenevinylene) were fabricated by miniemulsion solvent evaporation technique. Surface carboxylic acid groups were used to covalently attach amine-terminated polyethylene glycol (PEG) of different molecular weights. We investigated the effect of grafting CNPs with PEG chains on their intrinsic optical properties, protein adsorption behavior and uptake by representative brain cell lines. Findings: PEGylation did not affect the optical properties and biocompatibility of our CNPs. Moreover, a significant decrease in protein corona formation and unspecific uptake in central nervous system cell lines, depending on PEG chain length, was observed. This is the first report indicating that PEGylation does not affect the CNPs role as excellent bioimaging tools and can be adapted to tune biological interactions with brain cells. (C) 2020 Elsevier Inc. All rights reserved.Support for confocal microscopy was given by Prof. dr. Marcel Ameloot and Dr. Hannelore Bove. Cells were kindly provided by Prof. dr. Annelies Bronckaers, Dr. Jo Mailleux and dra. Jasmine Vanmol. Technical support was given by Huguette Penxten, Christel Bocken and Erik Royackers. Dr. Neomy Zaquen is acknowledged for the synthesis of the conjugated polymers. MP is grateful for funding from the IWT (Agentschap voor Innovatie door Wetenschap en Technologie). SS is an SB PhD Fellow at the Research Foundation Flanders (FWO). The work was funded by the Belgian Charcot Foundation. TJ is grateful for funding from the FWO in the form of an Odysseus grant. This work was supported by Hasselt University and the Research Foundation Flanders (FWO Vlaanderen; Hercules project AUHL/15/2 -GOH3816N). Additional support from BELSPO in the form of the interuniversity attraction pole (IAP) program P7/05: Functional Supramolecular Systems is kindly acknowledged. We further acknowledge the Hercules Foundation for the project (LC-MS@UHasselt: Linear Trap QuadrupoleOrbitrap mass spectrometer.Ethirajan, A (corresponding author), Hasselt Univ, Inst Mat Res, Wetenschapspk 1, B-3590 Diepenbeek, Belgium.
[email protected]
IoT Based Detection of Leakages in Gas Pipes
No full textIn industries leakage of Gas in the pipeline is a major issue nowadays. Leakage is defined as the accidental admission or escape of fluid through a hole or crack from the pipe. Gas leakages lead to losses as well as fire accidents. This project takes the control over automatic detection of leakages than the man power and thus reduce loss. Here we propose an inventive robot that clings on to the outer surface of the gas pipe and moves along the pipe to check for leakages. The kit consists of MQ5 gas sensor to detect the gas leakages. The robot moves continuously along the metal pipe, if there any presence of leakage the particular position is sensed by ultrasonic sensor and the message is send to the IOT through Wi Fi module. P. Anitha | K. Saranya "IoT Based Detection of Leakages in Gas Pipes" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-4 , June 2019, URL: https://www.ijtsrd.com/papers/ijtsrd23722.pd
Nanocapsules with stimuli-responsive moieties for controlled release employing light and enzymatic triggers
No full textThe development of stimuli-responsive nanomaterials, that possess tailored functional properties for the release of specific compounds, is of particular interest. To this extent, controlling the release of molecules at the desired target is an important parameter to regulate chemical and/or biological reactions at a more profound level in a wide variety of applications. In the present work, we report on the development of dual-responsive thiourethane-urethane nanocapsules synthesizedviaan interfacial polymerization reaction executed at the droplet interface using the inverse miniemulsion technique. Evidenceviamorphological and controlled release investigations indicate that our nanocapsules are able to encapsulate hydrophilic compounds with high efficiency in their aqueous core and allow for its selective release upon exposure to UV light and the enzyme esterase. Moreover, we demonstrate the efficient encapsulation of the fragrance molecule geranyl acetate and the anticancer drug doxorubicin. For the latter, we demonstrate its apoptotic effect after being released in MCF 7 breast cancer cells. Overall, these nanocapsules can be used for a wide variety of applications where a selective release of the payload is desired.S. S. is an SB PhD Fellow at the FWO (Research Foundation Flanders). S. K. P. acknowledges BOF funding from Hasselt University. This work is supported by Hasselt University and the Research Foundation Flanders (FWO Vlaanderen; Hercules project AUHL/15/2 - GOH3816N). The authors are thankful to Prof. M. Van Bael for access to the DLS device.Pramanik, SK; Ethirajan, A (corresponding author), Hasselt Univ, Inst Mat Res IMO, Wetenschapspk 1 & Agoralaan D, B-3590 Diepenbeek, Belgium; IMEC, Associated Lab IMOMEC, Wetenschapspk 1, B-3590 Diepenbeek, Belgium;
CSIR Cent Salt & Marine Chem Res Inst, Bhavnagar 364002, Gujarat, India.
[email protected]; [email protected]
Molecularly imprinted polymers as synthetic receptors for the QCM-D based detection of L-nicotine in saliva- and urine samples
No full text‘Policies on gender-based violence in UK universities: Understanding current practice, mapping future directions’. Ana Jordan (PI) and Sundari Anitha (Co-I). Funded by: University of Lincoln, College Research Fund. Total amount: £2776.88 (2019-2020).
No full textResearch Project: ‘Policies on gender-based violence in UK universities: Understanding current practice, mapping future directions’. Ana Jordan (PI) and Sundari Anitha (Co-I). Funded by: UOL College Research Fund. Total amount: £2776.88. Start Date: 1st September 2019.</p
Tuning the optical properties of poly(p-phenylene ethynylene) nanoparticles as bio-imaging probes by side chain functionalization
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