37 research outputs found
Impact de la modalité d’administration de la vancomycine intraveineuse chez l’enfant sur l’atteinte de l’objectif thérapeutique
No full textVancomycin is a glycopeptide whose efficacy depends on the time spent above the minimum inhibitory concentration. Intermittent intravenous infusion of this antibiotic is the most widely used administration method, but continuous infusion (CI) appears to be a good alternative in terms of efficacy, target attainment and safety in the adult population. Data supporting this hypothesis are scarce in the pediatric population. The aim of this single-center retrospective observational study was therefore to evaluate the efficacy of vancomycin infusion modalities in pediatrics in terms of time to reach therapeutic target. A total of 116 eligible vancomycin treatments courses were analyzed between January 2022 and May 2024, including 24 CI, 88 intermittent infusions (II) and 4 switches from II to CI. The proportion of patients reaching the target at the first vancomycin level measurement was 45.8% (N=11) for CI versus 25% (N=22) for II (p = 0.0472). Overall, the rate of target attainment anytime during treatment was 79.2% for CI versus 47.7% for II (p = 0.0061). Of the 4 patients who switched from II to CI, all reached their therapeutic target on the first post-switch level measurement. Continuous infusion appears to be more efficient in terms of time to target attainment, which is a prerequisite for optimal patient management during vancomycin therapy.La vancomycine est un antibiotique dont l’efficacité dépend du temps passé au-dessus de la concentration minimale inhibitrice. L’administration intra-veineuse discontinue de cet antibiotique est le mode d’administration le plus utilisé, cependant le mode d’administration en perfusion continue (PC) semble être une bonne alternative en termes d’efficacité d’atteinte de la cible thérapeutique et de tolérance dans la population adulte. Les données soutenant cette hypothèse sont peu nombreuses en population pédiatrique. L’objectif de cette étude rétrospective observationnelle monocentrique est donc d’évaluer l’efficacité des modalités de perfusion de vancomycine en pédiatrie en termes de rapidité d’atteinte de la fenêtre thérapeutique. Au total 116 traitements par vancomycine éligibles ont été recensés entre janvier 2022 et mai 2024 dont 24 PC, 88 perfusion discontinues (PDC) et 4 relais de la PDC vers la PC. La proportion d’atteinte de la fenêtre thérapeutique au premier dosage était de 45,8 % (N =11) pour la PC contre 25 % (N=22) en PDC (p = 0,047 2). Au total, le taux d’atteinte de cible à tout moment en cours de traitement était de 79,2 % en PC contre 47,7 % en PDC (p = 0,006 1). Concernant les 4 patients ayant eu un relais de la PDC vers la PC, tous les patients ont atteint leur cible thérapeutique dès le premier dosage suivant le relais par PC. La PC semble être plus efficace en termes de rapidité d’atteinte de la cible thérapeutique chez l’enfant, ce qui conditionne une prise en charge optimale du patient lors d’un traitement par vancomycine
The occurrence of Capercaillie in Polish Western Carpathians – conclusions from the monitoring in the years 2005-2010 and the final assessment of the quantity of Carpathian subpopulations of Capercaillie and Black Grouse
No full textNOVEL HIGH GLASS TRANSITION TEMPERATURE POLYURETHANES FUNCTIONALIZED WITH EFFICIENT CT CHROMOPHORES FOR SECOND ORDER NLO APPLICATION
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Novel High Glass Transition Temperature Polyurethanes Functionalized with Efficient CT Chromophores for Second Order NLO Applications
No full textIn this paper we describe the synthesis of a new class of high glass transition temperature polyurethanes functionalized with two quasi 1D charge transfer dyes. The polymers are soluble in several organic solvents and can be processed into thin films by spinning technique. The polymers were synthesized in view of their application in second order nonlinear optics for optical signal transmission. The active chromophores, exhibiting large first hyperpolarizabilities ss(- 2 omega,omega,omega) were poled by the corona poling technique. The kinetics of poling and of relaxation were studied by second harmonic generation technique
New polyurethane based push-pull chromophores functionalised polymers for NLO applications
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The monitoring of Eurasian lynx (Lynx lynx) in the Gorce National Park (Carpathians, Poland) with the use of camera trapping between 2014-2018: recommendations on the future species protection
No full textSynthesis, photophysical and electroluminescent properties of 1,3-diphenyl-1H-benzo[g]pyrazolo[3,4–b]quinoxaline
No full textAbstract Experimental investigations of electroluminescence spectra for new azaacene derivative have been performed. Azaacene was used as dopant in {PVK} matrices in electroluminescence devices with ITO/PEDOT:PSS/active layer/Ca/Al light-emitting diode configuration. The yellow emission was obtained with the electroluminance of 1530 cd/m2 at 15.0V
