41,061 research outputs found
Transfer of technology and developing countries to be published in, Foreign trade review, New Delhi January 1972. By Surendra j. Patel
No full textWith the compliments of Surendra J. Patel division for invisiblesと書かれた都留宛の献辞メモ (United Nations Conference on Trade and Development (UNCTAD)の様式) あり19 p.タイプ原稿オリジナルの所在: 一橋大学経済研究所資料室都留正子氏,和田昭允氏より寄贈2-M-3-0
Isolation of anaerobic, extremely thermophilic, sulphur metabolising archaebacteria from New Zealand hot springs
No full textEnrichments of New Zealand geo-thermal samples, initiated in anaerobic sulphur-containing media and incubated at temperatures above 85°C, yielded rod and coccal shaped organisms which possessed archaebacterial characteristics. Pure cultures were isolated and characterised. Five of the seven isolates, which were rod-shaped organisms and did not have an obligate requirement for sulphur respiration, were similar to Ther-moproteus sp. but had more neutral pH optima for growth. Three of these five Thermoproteus sp. were obligate heterotrophs, which has not previously been reported. The two coccal isolates had an obligate requirement for sulphur as an electron acceptor and were similar to Desulfurococcus sp. but again with more neutral pH optima for growth
Anti-inflammatory and antiosteo-clastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis
No full textThe development of biological therapies has improved management of rheumatoid arthritis. However, costs and unresponsiveness to therapy in a sizeable proportion of patients limit their use, making it imperative to identify new targets for drug development programs. Here we investigated the melanocortin-receptor type 3 (MC3) pathway. Gene-deficient mice were subjected to a model of serum-transfer-induced arthritis and joints analyzed for gene expression (cytokines, MCs) and morphology. Pharmacological analyses were also conducted in this model. Osteoclastogenesis was studied from bone marrow cells. Mc3−/− mice displayed an exacerbated inflammatory arthritis, associated with prominent bone erosion and higher articular expression of Rankl. Osteoclastogenesis studied from Mc3−/− bone marrow cells revealed a higher degree of responsiveness to Rankl, linked to prolonged NF-κB activation compared to wild types. Up-regulation of a discrete set of inflammatory genes, including Il-1β, Il-6, and Nos2, was measured in Mc3−/− mice, and a marked up-regulation of joint Mc3 accompanied arthritis resolution in wild-type mice. Administration of an MC3 agonist, D[Trp8]-γ-MSH, attenuated disease incidence and severity in wild-type but not Mc3−/− mice. Overall, these findings identify MC3-mediated signaling as a beneficial pathway in experimental arthritis; hence this receptor is a novel target for the development of therapeutics for arthritis.—Patel, H. B., Bombardieri, M., Sampaio, A. L. F., D'Acquisto, F., Gray, M., Grieco, P., Getting, S. J., Pitzalis, C., Perretti, M. Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis
Interpreting 750 GeV diphoton excess in SU(5) grand unified theory
No full textAbstract not availableKetan M. Patel, Pankaj Sharm
Synthesis, Characterisation and Antimicrobial Activities of Metal Chelates derived from α-Oximinoacetoacet-o / p-toluidide Thiosemicarbazone
No full textDepartment of Chemistry, Department of Biosciences, Sardar Patel University, Vallabh Vidyanagar-388 120
Manuscript received 11 March 1992, revised 16 November 1992, accepted 2 December 1992
Metal complexes of α-oximinoacetoacet-o/p-toluidide thiosemicarbazones (OAOTTS and OAPTTS) with NiII, CoII, ZaII, MNII , CdII, HgII and UOII have been prepared and characterised by elemental analyses, conductivity, differential scanning calorimetry study, thermogravimetric analyses and infrared and electronic spectral measurements in conjunction with magnetic susceptibility measurements. They have also been tested for their antibacterial activities
Computational investigation of binding of chloroquinone and hydroxychloroquinone against PLPro of SARS-CoV-2
No full textNovel coronavirus SARS-CoV-2 has infected 18 million people with 700,000+ mortalities worldwide and this deadly numeric figure is rapidly rising. With very few success stories, the therapeutic targeting of this epidemic has been mainly attributed to main protease (Mpro), whilst Papain-like proteases (PLpro) also plays a vital role in the processing of replicase polyprotein. Multifunctional roles of PLpro such as viral polypeptide cleavage, de-ISGlyation and immune suppression have made it a promising drug target for therapeutic interventions. Whilst there have been a number of studies and others are on-going on repurposing and new-small molecule screening, albeit previously FDA approved drugs viz. Chloroquine (CQ) and Hydroxychloroquine (HCQ) have only been found effective against this pandemic. Inspired by this fact, we have carried out molecular docking and dynamics simulation studies of FDA approved CQ and HCQ against SARS-CoV-2 PLpro. The end aim is to characterise the binding mode of CQ and HCQ and identify the key amino acid residues involved in the mechanism of action. Further, molecular dynamics simulations (MDS) were carried out with the docked complex to search for the conformational space and for understanding the integrity of binding mode. We showed that the CQ and HCQ can bind with better binding affinity with PLpro as compared to reference known PLpro inhibitor. Based on the presented findings, it can be anticipated that the SARS-CoV-2 PLpro may act as molecular target of CQ and HCQ, and can be projected for further exploration to design potent inhibitors of SARS-CoV-2 PLpro in the near future
Audio-visual fuzzy fusion for robust speech recognition
No full textImprovements of robustness of speech recognition is one of the hottest topics in speech signal processing, particularly when applied within a noisy
environment. Most of the research efforts focused in combining audio and visual data to implement an audio-visual speech recognition (AVSR) system. Bimodal approach demonstrated that a superior performance can be gained compared to the separate audio or visual approach. This paper proposes a fuzzy logic-based data fusion method that combines the recognition capabilities of two independent working systems namely the automatic speech recognition system (ASR) and the automatic visual recognition system (AVR). The main purpose is to boost the whole system’s performance
keeping the ASR separate from the AVR. This approach provides a powerful method that enables simpler data
fusion at decision level rather than the more complex at data and features level. Such complexity is also lowered
due to the fuzzy logic-based implementation of the data
fusion engine. Preliminary experimental results confirms the proposed approach
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