336 research outputs found
Papers Presented at the 6th World Energy System Conference, 6th World Energy System ConferenceTorino, Italy, 10-12 July 2006
No full text
Editorial WESC 2010 for Energy
No full textSpecial section - The 8th World Energy System Conference (WESC 2010
Engagement of ?v?3 integrin regulates proliferation and apoptosis of hepatic stellate cells
No full textHepatic stellate cells are the major source of the extracellular matrix that accumulates in fibrotic liver. During progressive liver fibrosis, hepatic stellate cells proliferate, but during resolution of fibrosis there is extensive stellate cell apoptosis that coincides with degradation of the liver scar. We have examined the possibility that the fate of stellate cells is influenced by the extracellular matrix through the intermediary of {alpha}v{beta}3 integrin. {alpha}v{beta}3 integrin was expressed by activated, myofibroblastic rat and human stellate cells in culture. Antagonism of this integrin using neutralizing antibodies, echistatin, or small inhibitory RNA to silence {alpha}v subunit expression inhibited stellate cell proliferation and their expression of proliferating cell nuclear antigen and activated forms of p44 and p42 MAPK. These {alpha}v{beta}3 antagonists also increased apoptosis of cultured stellate cells, and this was associated with an increase in the BAX/BCL-2 protein ratio, induction of nuclear DNA fragmentation, and activation of intracellular caspase-3. Expression of tissue inhibitor of metalloproteinases-1 by activated stellate cells was reduced by the {alpha}v{beta}3 antagonists, while matrix metalloproteinase-9 synthesis was enhanced. Stellate cells incubated with active recombinant matrix metalloproteinase-9 showed enhanced apoptosis, while cells treated with a synthetic inhibitor of this protease showed increased survival. Our studies suggest that {alpha}v{beta}3 integrin regulates the fate of hepatic stellate cells. Degradation of {alpha}v{beta}3 ligands surrounding activated stellate cells during resolution of liver fibrosis might decrease {alpha}v{beta}3 integrin ligation, suppressing stellate cell proliferation and inducing a fibrolytic, matrix metalloproteinase-secreting phenotype that may prime stellate cells for apoptosis
Institutional Engineering and Technology (IET) DEVELOPING A SIMPLE, INTERACTIVE AND EASY SIMULATION TOOL FOR THE TEACHERS/UNDERGRAD STUDENTS WITH A VIEW TO TEACHING/LEARNING CPU SCHEDULING ALGORITHMS Green Global Foundation © DEVELOPING A SIMPLE, INTERACT
No full textABSTRACT Nitu AM, Uddin MP, Islam MM, Islam MS (2015) Developing a simple, interactive and easy simulation tool for the teachers/undergrad students with a view to teaching/learning CPU scheduling algorithms. Ins. Engg. Tech. 5(1), 25-29. Operating System is one of the most significant courses for under-graduate students of Computer Science. In this paper a very simple, interactive and easy simulator has been developed for the teachers as well as the under-graduate students of computer science to teach as well as learn various CPU scheduling algorithms used for Operating System course. The key objective of using this simulator is to teach the students about the basic CPU scheduling algorithms visually. This will provide a clear and better understanding about how a scheduling policy executes. An undergraduate student will run the simulator and visualize how the processes get attention of the CPU following different scheduling policies
Efficacy and Safety of Ramucirumab in Asian and Non-Asian Patients with Advanced Hepatocellular Carcinoma and Elevated Alpha-Fetoprotein: Pooled Individual Data Analysis of Two Randomized Studies
No full textREACH-2 and REACH were randomized, placebo-controlled, double-blind, multicenter phase 3 trials which showed survival benefits of ramucirumab treatment in patients with advanced hepatocellular carcinoma (HCC) and elevated alpha-fetoprotein (AFP). We evaluated the efficacy and safety of ramucirumab in Asian and non-Asian patients with AFP ≥400 ng/mL from REACH-2 and REACH. Methods: We pooled Asian and non-Asian patients from the REACH-2 and REACH trials and performed an individual patient data meta-analysis. Overall survival (OS) and progression-free survival were evaluated using the Kaplan-Meier method. Hazard ratios (HRs) were estimated with a stratified Cox regression model. Results: In the pooled REACH-2 and REACH patient population, 291 Asian patients were randomly assigned to receive ramucirumab (n = 168) or placebo (n = 123), and 251 non-Asian patients received ramucirumab (n = 148) or placebo (n = 103). The median OS was significantly longer in the ramucirumab arm in comparison to the placebo arm for Asian patients (8.08 vs. 4.76 months, stratified HR 0.73 [95 CI 0.56-0.95], p = 0.0189) and non-Asian patients (7.98 vs. 5.22 months, stratified HR 0.65 [95 CI 0.49-0.86], p = 0.0028). The overall response rate (ORR) and disease control rate (DCR) were significantly higher in the ramucirumab arm compared to the placebo arm for Asian patients (ORR: 4.2 vs. 0.8; DCR: 53.6 vs. 33.3) and non-Asian patients (ORR: 6.8 vs. 1.0; DCR: 59.5 vs. 41.7). The most common grade ≥3 treatment-emergent adverse events reported in the ramucirumab arm were hypertension (7.7), decreased appetite (1.2), and ascites (1.2) for Asian patients and hypertension (16.9), ascites (8.8), asthenia (4.7), and fatigue (5.4) for non-Asian patients. Discussion and Conclusion: This pooled analysis of the REACH-2/REACH trials demonstrates significant benefits, with a manageable safety profile, of ramucirumab treatment in Asian and non-Asian patients with advanced HCC and baseline AFP ≥400 ng/mL
Novel mixed-metal cubane-type {Mo<inf>3</inf>NiS<inf>4</inf>} and {Mo<inf>3</inf>PdS<inf>4</inf>} clusters coordinated with 2,2′-bipyridine type ligands
No full text© 2018 Elsevier Ltd New cuboidal cluster complexes of general formula [Mo3S4(M′X)Cl3L3]0/+(M′ = Ni0, Pd0; L = dnbpy – 4,4′-dinonyl-2,2′-bipyridine or dbbpy – 4,4′-di-tert-butyl-2,2′-bipyridine; X = tu, Cl) were synthesized by reactions of trinuclear precursors [Mo3S4Cl3L3]+with Ni(COD)2(COD = 1,5-cyclooctadiene) or Pd2(dba)3·CHCl3(dba = dibenzylideneacetone) in the presence of thiourea (tu) in good yields. The complexes were characterized by elemental analysis, IR,1H NMR and ESI-MS techniques. Crystal structures of [Mo3S4(Nitu)Cl3(dbbpy)3]Cl·tu (1a), [Mo3S4(Nitu)Cl3(dbbpy)3]Cl (1b) and [Mo3S4(Pdtu)Cl3(dbbpy)3]Cl (2) were determined by X-ray analysis. The DFT calculations of the electronic structure of [Mo3S4(Pd′X)Cl3(bpy)3]0/+(X = Cl or tu) were carried out
Exploratory Study of the Companies’ Economic Performance Using a Social Customer Relationship Management
No full textAbstractThe epistemological positioning of scientific approach involves the diversity of the viewpoints of academics and specialists, exclusiveness not being considered. This paper aims to reflect own contributions to the development of management theory and management practice in Romania. First of all, the proposed scientific approach is a positivist approach, because it envisages the interposition of own reflections, an observation of what is happening in the market, an authentic presentation as it is. The main objective of this scientific research is to highlight the importance of social media as a mean of business development by creating new opportunities through promotion and a better brand visibility in the market. In the literature we have outlined a number of methods to assess the way in which companies approach the CRM: call method, the interview, the questionnaire, etc. Quantitative investigation of this paper was conducted based on assessment questionnaire, addressed to the employees of some Romanian companies. The qualitative investigation was conducted at the end of the research, based on analysis and structuring the information obtained. In this paper there were analyzed three elements: management position with the implementation of a CRM system; CRM to SCRM transition and the use of the new SM technologies in the implementation of a CRM system; applying of a SCRM system using social media platforms. As a result of the conducted study it was found that the media is one of the main trainers of public opinion, if not the main, controlling the public sphere. It conveys information, but also it controls and steers the public opinion. Thus, SM can form quickly enough media crisis to lower the public favorability for certain companies or politicians. In this way, by resorting to specific Social Media tools, the companies can obtain crucial information for evaluating the consumer satisfaction, information that would be more difficult to obtain traditionally
Novel mixed-metal cubane-type {Mo<inf>3</inf>NiS<inf>4</inf>} and {Mo<inf>3</inf>PdS<inf>4</inf>} clusters coordinated with 2,2′-bipyridine type ligands
No full text© 2018 Elsevier Ltd New cuboidal cluster complexes of general formula [Mo3S4(M′X)Cl3L3]0/+(M′ = Ni0, Pd0; L = dnbpy – 4,4′-dinonyl-2,2′-bipyridine or dbbpy – 4,4′-di-tert-butyl-2,2′-bipyridine; X = tu, Cl) were synthesized by reactions of trinuclear precursors [Mo3S4Cl3L3]+with Ni(COD)2(COD = 1,5-cyclooctadiene) or Pd2(dba)3·CHCl3(dba = dibenzylideneacetone) in the presence of thiourea (tu) in good yields. The complexes were characterized by elemental analysis, IR,1H NMR and ESI-MS techniques. Crystal structures of [Mo3S4(Nitu)Cl3(dbbpy)3]Cl·tu (1a), [Mo3S4(Nitu)Cl3(dbbpy)3]Cl (1b) and [Mo3S4(Pdtu)Cl3(dbbpy)3]Cl (2) were determined by X-ray analysis. The DFT calculations of the electronic structure of [Mo3S4(Pd′X)Cl3(bpy)3]0/+(X = Cl or tu) were carried out
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