47 research outputs found
Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells
No full textIs the concept of maternal tolerance preventing rejection of the semi-allogeneic 'fetal allograft' still valid?. Compilation of expert reviews of literature and recent advances in research on indoleamine-2,3 dioxygenase (IDO), regulatory T cells and galectin-1. A role for IDO in pregnancy success remains speculative, but solid data exist to support a role for Treg cells, and for galectin-1 in induction and action of Treg cells. Just as several signals may need to be simultaneously present to induce Th1 cytokine-triggered abortions, more than 1 signal may need to be simultaneously present to prevent rejection and ensure success. Both complement and coagulation pathways appear necessary for embryo execution.Fil: Terness, Peter. Universität Heidelberg; AlbaniaFil: Kallikourdes, Marinos. MRC Laboratory of Molecular Biology; Reino UnidoFil: Betz, Alexander G.. MRC Laboratory of Molecular Biology; Reino UnidoFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Saito, Shigeru. Universidad de Toyama; JapónFil: Clarck, David A.. Mc Master University; Canad
Epitope mapping and gene structure analysis of a human immunosuppressive natural IgG-anti-IgG autoantibody
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An Experimental Model for Preventing Alloimmunization against Platelet Transfusions by Pretreatment with Antibody-Coated Cells
No full textAn Experimental Model for Preventing Alloimmunization against Platelet Transfusions by Pretreatment with Antibody-Coated Cells
No full textAssociation of pre- and early post-transplant serum amino acids and metabolites of amino acids and liver transplant outcome.
No full textThe aim of the present study was to investigate association of serum amino (AA) acids and metabolites of AAs with post-transplant outcome in liver transplant recipients. Eighty-nine patients with end-stage liver diseases and available pre- and early post-transplant serum were characterised as patients with (GI) and without one-year mortality (GII) and patients with and without early graft dysfunction (EAD). A panel of pre- and early post-transplant serum levels of AAs and early and metabolites of tryptophan were measured using tandem mass spectrometry. Patient groups had significantly higher pre-transplant serum levels of phenylalanine, tryptophan, and tryptophan metabolites than healthy controls (for all p<0.001). Pre-transplant serum levels of all these parameters were significantly higher in GI than in GII (for all p<0.001). GI had a higher MELD score and re-transplantation number than GII (p≤0.005 for both investigations). Serum bilirubin on day 5 and serum phenylalanine on day 10 post-transplant were associated parameters of mortality, whereas day 1post-transplant phenylalanine and kynurenine and female gender were associated parameters of EAD. Our results indicate that pre- and early post-transplant levels of phenylalanine, tryptophan and metabolites of tryptophan are increased in patients and are associated with EAD and one-year mortality in liver transplant recipients
Immunization with Antigen-Bound Antibody: An Experimental Approach to Prevention of Sensitization to Allogeneic Blood Cells
No full textGeneration of FASL-expressing antigen-presenting cells for suppression of alloreactive T cells in the rat
No full textExquisitely small amounts of nonglucocorticoid natural steroids suppress the human allogeneic T-cell response
No full textAn immunoglobulin-specific autoantibody occurring during alloimmunization suppresses the antibody response
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