479 research outputs found
Lanyon-Orgill, Peter A. Captain Cook's South Sea Island Vocabularies
No full textHaudricourt André-Georges. Lanyon-Orgill, Peter A. Captain Cook's South Sea Island Vocabularies. In: Journal de la Société des océanistes, n°65, tome 35, 1979. p. 299
Lanyon-Orgill, Peter A. Captain Cook's South Sea Island Vocabularies
No full textHaudricourt André-Georges. Lanyon-Orgill, Peter A. Captain Cook's South Sea Island Vocabularies. In: Journal de la Société des océanistes, n°65, tome 35, 1979. p. 299
Discussion: Protective Effect of Hydrogen Gas Inhalation on Muscular Damage Using a Mouse Hindlimb Ischemia-Reperfusion Injury Model
No full textSupplemental Material - Theoretical and Pre-Clinical Models of Vacuum Assisted Closure
No full textSupplementary Material for Theoretical and Pre-Clinical Models of Vacuum Assisted Closure by Dennis P. Orgill and Amy K. McNulty in Surgical Innovation.</p
Lanyon-Orgill, Peter A. The language of Eddystone Island, Western Solomon Islands
No full textHaudricourt André-Georges. Lanyon-Orgill, Peter A. The language of Eddystone Island, Western Solomon Islands. In: Journal de la Société des océanistes, n°29, tome 26, 1970. p. 290
Biomaterials for treating skin loss /
No full textThis book provides a comprehensive review of biomaterials for treating skin loss.Part 1 Introduction: Development of skin substitutes -- Skin replacement products and markets -- Biomechanics of skin -- The pathophysiologic basis for wound healing and cutaneous regeneration -- Skin grafts -- Understanding the cellular basis of skin growth -- The regulatory approval process for biomaterials for treating skin loss. Part 2 Epidermal and dermal replacement technologies: Enhancing skin epidermal stability -- Human-derived acellular matrices for dermal replacement -- Lyophilized xenogenic products for skin replacement. Part 3 Combined dermis and epidermal replacement: Cultured skin substitutes -- The use of keratinocytes in combination with a dermal replacement to treat skin loss -- Principles of skin regeneration -- Summary: biomaterials for treating skin loss.This book provides a comprehensive review of biomaterials for treating skin loss.Dr Dennis P. Orgill is the Director of the Burn Center and leads the Wound Healing and Tissue Engineering at Brigham and Women's Hospital, Harvard Medical School, USA. Dr Orgill is highly regarded for his expertise in plastic surgical procedures. Dr Carlos Blanco is currently the CEO of the Joseph M. Still Research Foundation, Doctors' Hospital, Augusta, Georgia, USA. He has served on the Board of Directors of the American Burn Association, the International Society of Burn Injuries and the Wound Healing Society. Dr Blanco is renowned for his instrumental role in the development of Integra artificial skin.Elsevie
Skin Substitutes and Bioscaffolds: Temporary and Permanent Coverage
No full textAdvancements in surgical wound treatment have led to skin substitutes and bioscaffolds as temporary and permanent coverage for burn wounds. Skin substitutes are used to improve wound coverage and restore the functional and aesthetic qualities of skin, and help to prevent wound infection and maintain a moist wound healing environment. Although allografts are preferred when autografts are not possible, high costs and limited availability have led to the use of xenografts and the development of skin substitutes and bioscaffolds. Despite constant evolution in the development of these skin substitutes and bioscaffolds, no single product stands out as the gold standard
Wound healing kinetics of the genetically diabetic mouse
No full textThe increased number of chronic nonhealing wounds mirrors the epidemic of type 2 diabetes. Diabetic animal models may allow for better understanding of the pathophysiology of wound healing and may lead to the pre-clinical testing of a variety of therapeutic modalities for this patient group. The authors present an overview of the literature on excisional wound mouse models and focus on the authors' experience with the db/db mouse. Excisional wounds in wild type mice heal quickly due primarily to wound contraction, which is delayed in the db/db mouse. In this animal model it is possible to study and quantify the main mechanisms of healing and produce highly reproducible information. Differences in methodologies, infection control, as well as fine details such as the dressing option, partially explain heterogeneous results in the literature. Given the increase of the diabetic population, the db/db mouse model provides a powerful tool to study the effects of therapeutics for improving wound healing. The standardization of this animal model represents an important aspect to improve in the wound care field
Tissue-mimicking gelatin scaffolds by alginate sacrificial templates for adipose tissue engineering
Get PDFWhen adipose tissue (AT) is impaired by trauma or disease, AT engineering could provide a shelf-ready structural and functional restoration as alternative to current clinical treatments, which mainly aim at aesthetic replacement. Yet, the lack of an efficient vascular network within the scaffolds represents a major limitation to their translation application in patients. Here, we propose the use of microstructured crosslinked gelatin hydrogels with an embedded prevascular channel as scaffolding materials for AT engineering. The scaffolds are fabricated using – simultaneously – alginate-based microbeads and 3D printed filaments as sacrificial material encapsulated in gelatin at the point of material fabrication and removed post-crosslinking. This method yields the formation of microstructures that resemble the micro-architecture of physiological human fat tissue and of microvessels that can facilitate vascularization through anastomosis with patients’ own blood vessels. The cytocompatible method used to prepare the gelatin scaffolds showed structural stability over time while allowing for cell infiltration and protease-based remodeling/degradation. Scaffolds’ mechanical properties were also designed to mimic the one of natural breast adipose tissue, a key parameter for AT regeneration. Scaffold's embedded channel (∅ = 300–400 μm) allowed for cell infiltration and enabled blood flow in vitro when an anastomosis with a rat blood artery was performed using surgical glue. In vitro tests with human mesenchymal stem cells (hMSC) showed colonization of the porous structure of the gelatin hydrogels, differentiation into adipocytes and accumulation of lipid droplets, as shown by Oil Red O staining. Statement of Significance: The potential clinical use of scaffolds for adipose tissue (AT) regeneration is currently limited by an unmet simultaneous achievement of adequate structural/morphological properties together with a promoted scaffold vascularization. Sacrificial materials, currently used either to obtain a tissue-mimicking structure or hollow channels to promote scaffold’ vascularization, are powerful versatile tools for the fabrication of scaffolds with desired features. However, an integrated approach by means of sacrificial templates aiming at simultaneously achieving an adequate AT-mimicking structure and hollow channels for vascularization is missing. Here, we prove the suitability of crosslinked gelatin scaffolds obtained by using sacrificial alginate microbeads and 3D printed strands to achieve proper features and hollow channels useful for scaffolds vascularization
Facial-nerve regeneration ability of a hybrid artificial nerve conduit containing uncultured adipose-derived stromal vascular fraction: An experimental study
No full textThis study investigated the potential of uncultured-stromal-vascular-fraction (SVF) cells in promoting facial nerve regeneration in a rat model
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