2,530 research outputs found
Reactions in Endohedral Functionalized Cages
No full textThe introduction of enhanced functionalization is a key aspect in the current design of cage chemistry. At the moment, several approaches are intensively investigated. The synthesis of cage compounds that display endohedral functionalization plays a key role among them. Here, the studies of reactions that occur in endohedral-functionalized cage compounds is reviewed. After an introduction in current trends in cage-chemistry the discussion of reactions in endohedral-cage compounds is divided into three sections. These are: 1) Endohedral groups that are by themselves functional, 2) endohedral groups that can bind to a transition-metal complex and 3) endohedral groups that can bind by themselves to a metal. The article closes with an outlook on additional current developments in the field of endohedral-functionalized cage-compounds, which may contribute in the future towards reactivity in cage compounds.Endohedral‐functionalized cage compounds play an increasing role in cage chemistry. Here, the recent developments of reactions that are mediated or catalyzed by such endohedral‐functionalized cages is reviewed. The article is structured according to the role that the endohedral group plays with respect to the reaction mediated or catalyzed.
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‐funktionalisierten Käfig
No full textDeutsche Forschungsgemeinschaft https://doi.org/10.13039/501100001659Verband der Chemischen Industrie https://doi.org/10.13039/10000721
Catalytic Enantioselective Radical Cyclization via Regiodivergent Epoxide Opening
No full textA catalytic enantio- and diastereoselective radical cyclization using a regiodivergent epoxide opening (REO) for radical generation is described. It is demonstrated for the first time that the diastereoselectivity of cyclizations of acyclic radicals can be controlled catalytically. Building blocks for important applications in stereoselective synthesis are readily accessed
Radical Cyclizations Terminated by Ir-Catalyzed Hydrogen Atom Transfer
No full textA system for coupling catalytic radical cyclization and Ir-catalyzed hydrogen atom transfer (HAT) is described. It is essential that the HAT catalyst activates H(2) quickly and is not a hydrogenation catalyst. Vaska's complex was found to fulfill both purposes efficiently
A bio-inspired imidazole-functionalised copper cage complex
No full textAn imidazole-functionalised cage is synthesised that can coordinate to Cu( i ). X-ray analysis reveals a T-shaped coordination of copper by the imidazole ligands reminiscent of the coordination geometry found in enzymatic active sites. This cage complex can catalyse the oxidation of benzylic alcohols to benzaldehydes utilizing oxygen as the terminal oxidant
Matthias Wagner : author profile
No full textThe author presented on this page has published his 10. article in Angewandte Chemie in the last 10 years
Modulating Cytotoxic Effector Functions by Fc Engineering to Improve Cancer Therapy
Full text linkIn the last two decades, monoclonal antibodies have revolutionized the therapy of cancer patients. Although antibody therapy has continuously been improved, still a significant number of patients do not benefit from antibody therapy. Therefore, rational optimization of the antibody molecule by Fc engineering represents a major area of translational research to further improve this potent therapeutic option. Monoclonal antibodies are able to trigger a variety of effector mechanisms. Especially Fc-mediated effector functions such as antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement- dependent cytotoxicity (CDC) are considered important in antibody therapy of cancer. Novel mechanistic insights into the action of monoclonal antibodies allowed the development of various Fc engineering approaches to modulate antibodies' effector functions. Strategies in modifying the Fc glycosylation profile (Fc glyco-engineering) or approaches in engineering the protein backbone (Fc protein engineering) have been intensively evaluated. In the current review, Fc engineering strategies resulting in improved ADCC, ADCP and CDC activity are summarized and discussed.</jats:p
Size-Selective Molecular Flasks
Full text linkMolecular flasks are compounds that are able to mediate or catalyze chemical transformations inside their cavities. The development of such compounds is often inspired by nature. Enzymes, nature’s catalysts, are able to convert a certain substrate with very high turnover number and selectivity. In addition to their very high chemo-, regio-, and stereoselectivity, enzymes are also able to distinguish their substrates on the basis of size, resulting in size selectivity. To date, many synthetic materials such as metal–organic frameworks are used to accomplish size-selective transformations. However, also the number of molecular flasks known to mediate or catalyze size-selective transformations is increasing. In this perspective an overview on classic and the most recent examples of size-selective molecular flasks is given. In addition, an outlook on promising developments in cavity chemistry that may lead to the development of additional size-selective molecular flasks is given
Synthesis of an Fe(terpy-cage) 2 dumbbell
No full textA masked amine building block is used to synthesize an organic cage that is exo -functionalized with one terpy group. Two exo -functionalized cages can be combined via iron-terpy coordination resulting in a cage dumbbell.An azide masked amine is used to obtain a cage of lower symmetry that possess one terpy-group in an exo -position. This group can coordinate to iron( ii ), yielding selectively an easy to purify Fe(terpy-cage) 2 dumbbell. The dumbbell can also be obtained in a one pot reaction, which proceeded without isolation of the exo -functionalized cage
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