171,896 research outputs found
The invertebrate phagocytic immunocyte: Clues to a common evolution of immune and neuroendocrine systems
No full textIn invertebrates, lower vertebrates and higher vertebrates, a common pool of highly conserved molecules appears to mediate phagocytosis, the stress response and inflammation. Here, Enzo Ottaviani and Claudio Franceschi propose an evolutionary hypothesis based on an integrated network of adaptive mechanisms that are critical for survival. The macrophage plays a pivotal role in this process
Università G. d’Annunzio Chieti-Pescara, DdA Dipartimento di Architettura con P. Misino, M. Angrilli, S. Ferrini, R. Ottaviani
No full textPresentazioen del progetto elaborato dal gruppo dell'Università di Chieti-Pescara composto da P. Misino, M. Angrilli, S. Ferrini, R. Ottaviani, C. Varagnol
Relazione per il Progetto per la Grande Villa Adriana - Piranesi Prix de Rome
No full textPresentazioen del progetto elaborato dal gruppo dell'Università di Chieti-Pescara composto da P. Misino, M. Angrilli, S. Ferrini, R. Ottaviani, C. Varagnol
Impulsivity and household indebtedness: evidence from real life
No full textUsing a probit model, we estimated the role of emotional factors in determining household participation in the debt market, after controlling for such traditional economic predictors as age, level of education, income, wealth, and work status. A sample of 445 Caucasian subjects selected among fulltime employees at international asset management companies underwent the Barratt Impulsiveness Scale, the Iowa Gambling Task (IGT) while skin conductance was recorded, and a series of questions related to their demographic-socio-economic profile. Aside from confirming the role played by traditional explanatory variables commonly used as determinants of household indebtedness, results revealed the significant influence of individuals' impulsivity in making debt decisions. Impulsivity predicted unsecured debt (i.e. consumer credit), but it was not significantly associated with secured debt (i.e. mortgages). Neither presence of a somatic marker to guide decisions nor performance at the IGT predicted real-life indebtedness decisions in this non-clinical sample. The notion that "non-rational" factors influence debt demand has been largely ignored and raises concerns about the risk of over-indebtedness for impulsive individuals. (C) 2011 Elsevier B.V. All rights reserved
EVIDENCE FOR THE PRESENCE OF IMMUNOREACTIVE POMC-DERIVED PEPTIDES AND CYTOKINES IN THE THYMUS OF THE GOLDFISH (CARASSIUS-C-AURATUS)
No full textThe presence of immunoreactive pro-opiomelanocortin (POMC)-derived peptides (adrenocorticotropin hormone, beta-endorphin, alpha-melanocyte-stimulating hormone) and of cytokine-like molecules [interleukin (IL)-1 alpha, IL-1 beta, IL-2, IL-6, tumour necrosis factor-alpha] was demonstrated in periodic acid-Schiff-positive epithelial cells in the thymus of the goldfish (Carassius c. auratus) using immunocytochemical procedures. POMC-derived peptide- and cytokine-like molecules were localized in the same cell type. Lymphocytes were negative for all the above mentioned molecules. Despite the smaller number of cells positive for neuropeptide- and cytokine-like molecules, our findings suggest that immune-neuroendocrine interactions are likely to occur in the thymus of goldfish
A new theory on the common evolutionary origin of natural immunity, inflammation and stress response: The invertebrate phagocytic immunocyte as an eye-witness
No full textData in favor of the hypothesis of the common evolutionary origin of natural immunity inflammation and stress response are presented. These phenomena seem to be mediated by a common pool of molecules (POMC-derived peptides, cytokines, biogenic amines, glucocorticoids, and nitric oxide). Macrophages are able to release all the above mentioned molecules. They play a primary role in defence mechanisms. Thus, we argue that this cell can be considered the eye-witness of the common evolutionary origin of the immune and neuroendocrine systems
La Conférence épiscopale française et l’enquête Ottaviani
No full textLa réponse française à la lettre adressée le 24 juillet 1966 par le cardinal Ottaviani, pro-préfet de la Congrégation pour la doctrine de la foi, aux présidents des conférences épiscopales pour leur demander de signaler les « abus grandissants dans l’interprétation de la doctrine du Concile » et les « opinions étranges et audacieuses apparaissant ici ou là » est la seule qui ait fait l’objet d’une publication officielle, autorisée par le dicastère concerné quelques semaines après son envoi. C..
Contribution of invertebrate models to aging and longevity studies
No full textThis paper summarizes pros and cons of the invertebrate models involved in aging and longevity. The worm Caenorhabditis elegans and the fruit fly Drosophila melanogaster are the two models that have given the major contributions on this topic. Furthermore, we also discuss the possible contribution of recent theories on aging and inflammation to understand the complex phenotype of aged soma, from invertebrates to humans
INFLUENCE OF ENDORPHINS ON THE MIGRATION OF MOLLUSCAN HEMOCYTES
No full textThe influence of endorphins on the hemocyte migration of two molluscs, Planorbarius corneus and Viviparus ater, was tested. The whole sequence of beta-endorphin and its N- and C-terminal fragments stimulate hemocyte migration. Naloxone is able to partially reverse the endorphin effect. In V. ater hemocytes, the acetylated derivative of beta-endorphin has a significant stimulatory effect at lower concentration
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