1,721,273 research outputs found
beta-N-acetyl-D-glucosaminidase activity levels in atrophic gastrocnemius muscle of Rana esculenta
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Up-regulation of glycohydrolases in Alzheimer's Disease fibroblasts correlates with Ras activation
No full textCompositions and methods for treatment of Parkinson's disease: a patent evaluation of WO2011/102847A1
No full textBackground: The application (WO2011/102847A1) deals with methods useful for the treatment of Parkinson's disease (PD). Objective: It aims at producing mature and functional midbrain dopaminergic (mDA) neurons useful for the treatment of PD. Methods: mDA neurons were produced from neural progenitor cells or stem cells by activating both the Wnt-Lmx1a/Lmx1b and the SHH-FoxA2 signaling pathways. Results: The level of the proteins of these two synergic pathways is increased, as well as their biological activity. Conclusion: The invention provides a method for treating or preventing PD by increasing the level of at least one protein involved in an autoregulatory pathway, which is fundamental during mDA neurons differentiation
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