258 research outputs found
Hypertension management and prevention: The devil is ever in the details of targets
No full textAnnals of the Academy of Medicine Singapore4610364-36
The Annals: Welcoming the future of Medicine
No full text10.47102/annals-acadmedsg.2021530Annals of the Academy of Medicine, Singapore5012877-87
Toward Live Migration of SGX-Enabled Virtual Machines
No full textIntel Software Guard Extensions (SGX) can address the information disclosure in cloud computing. However, the existing virtual machine managers do not provide the efficient management operations of the SGX-enabled virtual machines (VMs) like live migration. In this paper, we identify challenges and propose a novel approach and its implementation model to migrate the SGX-enabled VMs. As future work, we will design the protocol and new instructions for live migration of the SGX-enabled VMs, and implement them on top of OpenSGX, an open source SGX emulator
Disk management of the VAX/VMS disk subsystem
No full textThe disk storage subsystem on a VAX/VMS system plays an Important role in overall system performance. All VMS systems, from MicroVaxes to 8800s, depend on disk media to provide accessibility to the users\u27 data. Since all computers are truly information processors, the disk storage subsystem in a modern computing environment can be very costly if it is not properly managed. Disk management is therefore a proper concern for all system managers, however, it is all to often a tedious, time-consuming management task.
Efficient disk management requires that a disk\u27s major characteristics be monitored and made readily available to the disk system manager. Currently, many VMS utilities must be used to gather this important information. It is the goal of the author to provide a single source utility to simplify the burden associated with disk management. If disk system management is sufficiently understood and its limitations are known, proper disk system management can be a very interesting and rewarding pursuit
Correct energy evolution of stabilized formulations: The relation between VMS, SUPG and GLS via dynamic orthogonal small-scales and isogeometric analysis. II: The incompressible Navier–Stokes equations
No full textThis paper presents the construction of a correct-energy stabilized finite element method for the incompressible Navier–Stokes equations. The framework of the methodology and the correct-energy concept have been developed in the convective–diffusive context in the preceding paper [M.F.P. ten Eikelder, I. Akkerman, Correct energy evolution of stabilized formulations: The relation between VMS, SUPG and GLS via dynamic orthogonal small-scales and isogeometric analysis. I: The convective–diffusive context, Comput. Methods Appl. Mech. Engrg. 331 (2018) 259–280]. The current work extends ideas of the preceding paper to build a stabilized method within the variational multiscale (VMS) setting which displays correct-energy behavior. Similar to the convection–diffusion case, a key ingredient is the proper dynamic and orthogonal behavior of the small-scales. This is demanded for correct energy behavior and links the VMS framework to the streamline-upwind Petrov–Galerkin (SUPG) and the Galerkin/least-squares method (GLS). The presented method is a Galerkin/least-squares formulation with dynamic divergence-free small-scales (GLSDD). It is locally mass-conservative for both the large- and small-scales separately. In addition, it locally conserves linear and angular momentum. The computations require and employ NURBS-based isogeometric analysis for the spatial discretization. The resulting formulation numerically shows improved energy behavior for turbulent flows comparing with the original VMS method.Accepted Author ManuscriptShip Hydromechanics and Structure
The J-shell command language interpreter
No full textA command language interpreter (CLI) translates commands entered by the user into system actions. The shell is a specific type of CLI that was originally designed and used with UNIX operating systems.The author proposes to design and implement a shell-like CLI on top of the VMS operating system. The shell will enhance VMS features by providing an easier to use syntax and by providing features that are not currently available through VMS. These features include piping facilities and the ability to enter and/or reference multiple commands from a single command line. A language reference manual is provided with the J-shell. This manual explains the features and commands of the J-shell.Thesis (M.S.
How much of the seabed is impacted by mobile fishing gear? Absolute estimates from Vessel Monitoring Systems (VMS) point data
No full textPeer- reviewed This is a pre-copy-editing, author-produced PDF of an article accepted for publication in ICES Journal of Marine Science following peer review. The definitive publisher-authenticated version is available online at: doi: 10.1093/icesjms/fst017Demersal trawling impacts extensively on the seabed and the extent and frequency of this impact can be assessed using Vessel Monitoring Systems (VMS) data (positional data of fishing vessels). Existing approaches interpolate fishing tracks from consecutive VMS locations (track interpolation) and/or aggregate VMS point data in a spatial grid (point summation). Track interpolation can be quite inaccurate at the current 2-hour time interval between VMS records, leading to biased estimates. Point summation approaches currently only produce relative estimates of impact and are highly sensitive to the grid size chosen We propose an approach that provides absolute estimates of trawling impact from point data and is not sensitive to an arbitrary choice of grid cell size. The method involves applying a nested grid and estimating the swept area (area covered by fishing gear) for each VMS point. We show that the ratio of the swept area to the surface area of a cell can be related to the proportion of the seabed that was impacted by the gear a given number of times. We validate the accuracy of this swept-area ratio approach using known vessel tracks and apply the method to international VMS data in the Celtic Sea.Funder: Marine Institut
On the precision of predicting fishing location using data from the Vessel Monitoring System (VMS)
No full textDefining fishing grounds based on data from Vessel Monitoring System (VMS) has been a widely-researched topic in recent years. Much of the research has focused on filtering algorithms for identifying fishing locations from VMS point data, most often supplemented with either imputed or reported vessel speed information. This study compared the precision of categorizing fishing locations from VMS data either by the most wide-spread â speed ruleâ approach or a probability model. Using data from Northeast U.S. Fisheries for fishing years 2010-2014, we showed that the traditional representation of fishing activities as derived by speed rules leads to a severe misrepresentation of fishing grounds for gears other than bottom otter trawl. Predictions based on probability models outperformed gear-specific speed rules in classifying VMS polls for sink gillnet and scallop dredge trips, without adding substantial computational effort. The probability models thus provide the largest improvements in gears with complicated fishing patterns, while controlling for issues, such as fleet dynamics, that historically have not been dealt with in the static speed rules, but which can have significant impacts on the quality of predictions.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author
Eigensystem realization algorithm user's guide forVAX/VMS computers: Version 931216
No full textThe eigensystem realization algorithm (ERA) is a multiple-input, multiple-output, time domain technique for structural modal identification and minimum-order system realization. Modal identification is the process of calculating structural eigenvalues and eigenvectors (natural vibration frequencies, damping, mode shapes, and modal masses) from experimental data. System realization is the process of constructing state-space dynamic models for modern control design. This user's guide documents VAX/VMS-based FORTRAN software developed by the author since 1984 in conjunction with many applications. It consists of a main ERA program and 66 pre- and post-processors. The software provides complete modal identification capabilities and most system realization capabilities
Verminoside from Pseudolysimachion rotundum var. subintegrum sensitizes cisplatin-resistant cancer cells and suppresses metastatic growth of human breast cancer
No full textBreast cancer is one of the most common cancers in women and is associated with a high mortality rate. The majority of deaths resulting from breast cancer are attributable to metastatic growth; in addition, chemoresistance is a major concern in the treatment of patients with breast cancer. However, limited drugs are available for the treatment of metastatic breast cancer. In this study, the chemoadjuvant effects of a methanolic extract from the leaves of Pseudolysimachion rotundum var. subintegrum (NC13) and an active component isolated from the plant, verminoside (Vms), were evaluated. Furthermore, their potent anti-metastatic activities were validated in vitro and in vivo in animal models. The anti-metastatic and chemosensitizing activities of NC13 and Vms on cisplatin treatment were found to be partly mediated by suppression of the epithelial-mesenchymal transition of cancer cells. Collectively, our results implied that NC13 and its bioactive component Vms could be developed as effective chemoadjuvants in combination with conventional therapeutics
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