3 research outputs found
Safety, anti-inflammatory and analgesic assessments of methanolic extract of Musa paradisiaca peel in Sprague Dawley rats
No full textBackground: Musa paradisiaca peel is used in folklore for the treatment of inflammation and pains without any scientific evidence. Objective: The present study, therefore, evaluated the safety, anti-inflammatory and analgesic effects of the methanolic extract of M. paradisiaca peel. Methods: The methanolic extract of M. paradisiaca was administered orally in three different doses; 100, 200 and 400 mg/kg to Sprague Dawley rats. The anti-inflammatory effect of M. paradisiaca peel was tested in egg albumin-induced paw edema and compared to ibuprofen (25 mg/kg). The analgesic effect was evaluated using formalin-induced paw licking and acetic acid-induced writhing and compared to indomethacin (10 mg/kg). Also, after 21 days of extract administration rats were sacrificed serum was extracted from blood and evaluated for liver, renal function indices and lipid profile. Kidney and liver were excised and weighed. Results: The methanolic extract of M. paradisiaca produced analgesia and decreased inflammation significantly (p<0.05) and in a dose dependent manner. The anti-inflammatory and analgesic effects were significant (p<0.05) at 400 mg/kg of M. paradisiaca when compared to ibuprofen (25mg/kg) and indomethacin (10mg/kg) respectively. Furthermore, M. paradisiaca did not produce significant (p>0.05) effects on organ weight, serum alkaline phosphatase, aminotransferases, conjugated bilirubin, total bilirubin, total cholesterol, triglyceride, low density lipoprotein, high density lipoprotein, glucose, creatinine, urea, uric acid, total protein, albumin, and serum electrolytes when compared to control. Conclusion: This study observed that the methanolic extract of M. paradisiaca peel has anti-inflammatory and analgesic effects and may be safe with use. Key words: Musa paradisiaca, anti-inflammatory, analgesic, toxicity, rat
Thirty-five years (1986–2021) of HIV/AIDS in Nigeria: bibliometric and scoping analysis
No full textBackground
Acquired immunodeficiency syndrome (AIDS) is an acquired defect of the cellular immunity associated with the infection by the human immunodeficiency virus (HIV). The disease has reached pandemic proportion and has been considered a public health concern. This study is aimed at analyzing the trend of HIV/AIDS research in Nigeria.
Method
We used the PUBMED database to a conduct bibliometric analysis of HIV/AIDS-related research in Nigeria from 1986 to 2021 employing “HIV”, “AIDS”, “acquired immunodeficiency syndrome”, “Human immunodeficiency virus”, and “Nigeria” as search description. The most common bibliometric indicators were applied for the selected publications.
Result
The number of scientific research articles retrieved for HIV/AIDS-related research in Nigeria was 2796. Original research was the predominant article type. Articles authored by 4 authors consisted majority of the papers. The University of Ibadan was found to be the most productive institution. Institutions in the United States dominated external production with the University of Maryland at the top. The most utilized journal was PLoS ONE. While Iliyasu Z. was the most productive principal author, Crowel TA. was the overall most productive author with the highest collaborative strength. The keyword analysis using overlay visualization showed a gradual shift from disease characteristics to diagnosis, treatment and prevention. Trend in HIV/AIDS research in Nigeria is increasing yet evolving. Four articles were retracted while two had an expression of concern.
Conclusion
The growth of scientific literature in HIV/AIDS-related research in Nigeria was found to be high and increasing. However, the hotspot analysis still shows more unexplored grey areas in future.Depto. de Optometría y VisiónFac. de Óptica y OptometríaTRUEpu
Design of an Information Security Model for Research Projects in the Environmental Area
No full textEste documento presenta la propuesta de diseño conceptual para un modelo de seguridad de la información aplicado a proyectos de investigación en el ámbito medioambiental. La iniciativa surge a partir de la necesidad de responder a las particularidades operativas y normativas de estos entornos, en los que se gestionan datos sensibles, distribuidos y sujetos a riesgos específicos. El modelo propuesto se estructura conforme al ciclo PHVA (Planificar, Hacer, Verificar, Actuar). Integra lineamientos de normas internacionales como ISO/IEC 27001:2022, ISO/IEC 27002:2022, ISO/IEC 27005:2022, MAGERIT v3 y NIST SP 800-53 Rev. 5. Esta base normativa permite establecer un enfoque sistemático para la identificación, análisis y tratamiento de riesgos, alineado con los objetivos de investigación y las condiciones técnicas del entorno. El diseño contempla políticas, prácticas y controles organizados por función (preventivos, detectivos, correctivos y disuasivos), clasificados según el nivel de riesgo de los activos y su nivel de madurez tecnológica. Sumado a esto, incorpora mecanismos de segmentación, trazabilidad y documentación que favorecen su aplicación en contextos institucionales o programas de investigación científica. El resultado es un modelo conceptual integral que, al alinear marcos normativos con las particularidades del sector, constituye una guía estratégica para fortalecer la protección de activos críticos y mejorar la resiliencia operativa en proyectos de investigación medioambiental.This document presents a conceptual design proposal for an information security model applied to environmental research projects. The initiative arises from the need to address the operational and regulatory particularities of these environments, where sensitive, distributed data are managed and subject to specific risks. The proposed model is structured according to the PDCA cycle (Plan, Do, Check, Act). It integrates guidelines from international standards such as ISO/IEC 27001:2022, ISO/IEC 27002:2022, ISO/IEC 27005:2022, MAGERIT v3, and NIST SP 800-53 Rev. 5. This normative foundation enables a systematic approach to the identification, analysis, and treatment of risks, aligned with research objectives and the technical conditions of the environment. The design includes policies, practices, and controls organized by function (preventive, detective, corrective, and deterrent), classified according to the risk level of the assets and their technological maturity. In addition, it incorporates segmentation, traceability, and documentation mechanisms that support its application in institutional contexts or scientific research programs. The result is a comprehensive conceptual model that, by aligning regulatory frameworks with sector-specific characteristics, serves as a strategic guide to strengthen the protection of critical assets and enhance operational resilience in environmental research projects
