1,723,737 research outputs found
Oddo, S.
No full textCentro Asturiano membership record of S. Oddo; Socio Number: 89886.https://digitalcommons.usf.edu/asturiano_membership/4575/thumbnail.jp
Oddo, Philip
No full textCentro Asturiano membership record of Philip Oddo; Socio Number: 125149.https://digitalcommons.usf.edu/asturiano_membership/4625/thumbnail.jp
Oddo, Antonina
No full textCentro Asturiano membership record of Antonina Oddo; Socio Number: 992.https://digitalcommons.usf.edu/asturiano_membership/4711/thumbnail.jp
"Smart" lipid microbubbles for targeting and drug delivery
No full text“Smart” lipid microbubbles for targeting and drug delivery
Gaio Paradossi, Barbara Cerroni, Letizia Oddo
Dipartimento di Scienze e Tecnologie Chimiche, Università di Roma Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, Italy.
Lipid microbubbles are known as ultrasound contrast agents (UCAs). They consist of hydrophobic gas, tipically a perfluorocarbon or sulfur hexafluoride, encapsulated by a shell of surfactant molecules assembled as monolayer.
To address UCAs on tumor endothelial cells, we decorated their surface with the cyclic pentapeptide, cyclo(Arg-Gly-Asp-D-Phe-Cys) ), containing the sequence RGD, or its analog cyclo(Arg-Ala-Asp-D-Phe-Cys) with a RAD sequence as positive control. RGD sequence is recognized by integrins, the transmembrane proteins overexpressed by tumor endothelial cells or human umbilical vein endothelial cells (HUVEC). In this contribution we tested the bioadhesion of RGD decorated UCAs under controlled and realistic flow conditions such as shear rate, channel diameter, temperature on HUVEC and, as positive control, on fibrablasts NIH3T3 cell lines.
Sonoporation, the reversible opening of cell membrane upon ultrasound irradiation, can be a method to favor the internalization of drugs. However, a careful optimization of the process is needed to warrant cells viability. The presence of the microbubbles affects the efficiency of the method.
This research has been supported by the FP7 Eu project “TheraGlio”.
“Smart” lipid microbubbles for targeting and drug delivery
Gaio Paradossi, Barbara Cerroni, Letizia Oddo
Dipartimento di Scienze e Tecnologie Chimiche, Università di Roma Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, Italy.
Lipid microbubbles are known as ultrasound contrast agents (UCAs). They consist of hydrophobic gas, tipically a perfluorocarbon or sulfur hexafluoride, encapsulated by a shell of surfactant molecules assembled as monolayer.
To address UCAs on tumor endothelial cells, we decorated their surface with the cyclic pentapeptide, cyclo(Arg-Gly-Asp-D-Phe-Cys) ), containing the sequence RGD, or its analog cyclo(Arg-Ala-Asp-D-Phe-Cys) with a RAD sequence as positive control. RGD sequence is recognized by integrins, the transmembrane proteins overexpressed by tumor endothelial cells or human umbilical vein endothelial cells (HUVEC). In this contribution we tested the bioadhesion of RGD decorated UCAs under controlled and realistic flow conditions such as shear rate, channel diameter, temperature on HUVEC and, as positive control, on fibrablasts NIH3T3 cell lines.
Sonoporation, the reversible opening of cell membrane upon ultrasound irradiation, can be a method to favor the internalization of drugs. However, a careful optimization of the process is needed to warrant cells viability. The presence of the microbubbles affects the efficiency of the method.
This research has been supported by the FP7 Eu project “TheraGlio”
Disquiet Depictions
Get PDFOlivia Oddo
Disquiet Depictions
Laura Mesaros Gallery
MFA Thesis Exhibition
March 2020https://researchrepository.wvu.edu/disquiet-depictions/1008/thumbnail.jp
Le Duc Henri de Joyeuse devenu ‘frère Ange’ : une héroïsation entre histoire et fiction
No full textOddo Nancy. Le Duc Henri de Joyeuse devenu ‘frère Ange’ : une héroïsation entre histoire et fiction. In: Seizième Siècle, N°4, 2008. pp. 237-253
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 1 (84)]
No full textTestament des Oddo, Archidiakon der Kathedrale von CremonaHandschrift DE-3, GND 2024680-8, Signatur: Morbio 1 (84)Überlieferungsart: kopialBeschreibstoff: PergamentErhaltungszustand: gutHandschriftUrkund
Disquiet Depictions
No full textOlivia Oddo
Disquiet Depictions
Laura Mesaros Gallery
MFA Thesis Exhibition
March 2020https://researchrepository.wvu.edu/disquiet-depictions/1007/thumbnail.jp
Marriage record of Oddo, Nicola Salvatore and Lamanno, Antoninia
No full textMarriage license for Nicola Salvatore Oddo and Antoninia Lamanno. Wagner.A.L. was the officiant
Antoine de Nervèze : pieux Protée ou caméléon mondain ?
No full textOddo Nancy. Antoine de Nervèze : pieux Protée ou caméléon mondain ?. In: Littératures classiques, n°31, automne 1997. Les « minores ». pp. 39-62
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