8,785 research outputs found
Modeling biomedical experimental processes with OBI
No full text© 2010 Soldatova et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Background: Experimental descriptions are typically stored as free text without using standardized terminology, creating challenges in comparison, reproduction and analysis. These difficulties impose limitations on data exchange and information retrieval. Results: The Ontology for Biomedical Investigations (OBI), developed as a global, cross-community effort, provides a resource that represents biomedical investigations in an explicit and integrative framework. Here we detail three real-world applications of OBI, provide detailed modeling information and explain how to use OBI. Conclusion: We demonstrate how OBI can be applied to different biomedical investigations to both facilitate interpretation of the experimental process and increase the computational processing and integration within the Semantic Web. The logical definitions of the entities involved allow computers to unambiguously understand and integrate different biological experimental processes and their relevant components. Availability: OBI is available at http://purl.obolibrary.org/obo/obi/2009-11-02/obi.owlThe National Institute of Biomedical Imaging and Bioengineering, National Human Genome Institute, the Intramural Research Program of the NIH and NIEHS, the Bio-Informatics Research Network
Coordinating Center, EC FELICS, MUGEN, BBSRC, RC UK, NERC-NEBC, EU IP CarcinoGenomics, EU NoE NuGO, CARMEN project EPSRC, NERC-NEBC, EU IP CarcinoGenomics, EU NoE NuGO, the Michael Smith Foundation for Health Research, and the Public Health Agency of Canada/Canadian Institutes of Health Research Influenza Research Network
An integrated socio-cyber-physical system framework to assess responsible digitalisation in agriculture: A first application with Living Labs in Europe
No full textMetta, M., Ciliberti, S., Obi, C., Bartolini, F., Klerkx, L., & Brunori, G. (2022). An integrated socio-cyber-physical system framework to assess responsible digitalisation in agriculture: A first application with Living Labs in Europe. Agricultural Systems, 203, 103533
The impact of EC-92 on developing countries'trade : a dissenting view
No full textMost benefits of the European Community (EC-92) program will probably not come from marginal changes in trade flows. Those changes are important to European policymakers, but are of remote interest to developing countries. The main threats to developing countries are the diversion of investment funds to EC countries and continued external barriers, especially nontariff barriers. The EC expects higher growth and lower prices as a result of EC-92. The net effect on developing countries of the removal of internal trade barriers depends on the country's income and price elasticities with the EC. Current estimates suggest the effect will be small. If new external barriers emerge, or if EC-wide barriers replace national barriers, EC firms may collaborate more with large US or Japanese firms. None of these developments will improve developing countries'trade in manufactures and services. Investment in EC countries may increase to meet the extra demand, growth, or trade diversion resulting from EC-92. This could lead to increased investments in developing countries but given heavy indebtedness in developing countries, is more likely to divert investment funds, thus limiting their future production and growth. Technical standards in EC-92 may also be tougher than national standards in member countries, which could hurt developing country exporters. Is"Fortress Europe"likely? The EC Commission says no, but the Community's record is not good.Environmental Economics&Policies,Economic Theory&Research,TF054105-DONOR FUNDED OPERATION ADMINISTRATION FEE INCOME AND EXPENSE ACCOUNT,Trade and Regional Integration,Trade Policy
EC Bananarama 1992 : the sequel - the EC Commission proposal
No full textSome European Community (EC) countries give preferred market access and high prices to bananas from selected developing countries or EC regional suppliers. This preferential status is regarded as a form of aid to these countries, most of which are developing small island economies. EC marketers of bananas from these preferred suppliers also benefit because of the high retail prices. Nonpreferred suppliers - mainly developing countries of Latin America - are hurt by the policies because access is denied or restricted and the lower demand depresses the world price for bananas. The Community's commitment to establish a single unified EC banana market on December 31, 1992 provides a timely opportunity to reform existing distortionary trade policies. The recently announced proposal of the Commission of ECs to regulate banana trade within a unified market relies on quotas to control imports. The proposal is extremely complicated. It is designed to severely restrict competition and to maintain the advantages of selected groups. The authors update their earlier analysis of world banana trade to reflect the market in 1993. They evaluate the implications of the Commission's proposal alongside existing and alternative policies. They find that current policies cost EC consumers about 0.3 billion a year to preferred suppliers. So, it costs EC consumers about 1.00 of aid toselect developing countries or regions. Additionally, every dollar of aid reaching preferred suppliers costs other developing country suppliers 5.30 cost to EC consumers, over 1.00 is lost in outright waste. Several plausible versions of the Commission's proposal are modelled. At best they are found to be slightly less costly than existing policies and at worst, considerably more costly. A 3.5 percent reduction in the quota allocation is estimated to lead to a 30 percent increase in the cost of the proposal. The authors conclude that the Commission's proposal for a unified EC banana policy appears to be little more than a way of replacing existing distortionary national policies with an almost equally distortionary single policy and market. The only difference: the costs would be borne by consumers in all EC countries rather than consumers in only some countries. Worse still, costs could increase. Markets that now gain the benefits of mostly open and competitive marketing such as Germany would face closed and uncompetitive conditions. For developing countries exporting bananas, the proposal offers little. At best conditions may be no worse than they are now. At worst the policy could hurt Latin American suppliers even more than current policies and introduce considerable confusion about the level of support to preferred suppliers. Under the proposed quota system aid will not be well targeted. A more efficient way of achieving the EC's aid commitment is through a small tariff of about 17 percent, used to fund a system of well-targeted deficiency payments or direct aid. The only reason for choosing the Commission's proposal over simpler, tariff-based options seems to be to maintain the vested interests of protected EC markteters. But this is contrary to the objectives of unification, which are to seek gains from increased competition and trade.Environmental Economics&Policies,Access to Markets,Markets and Market Access,Economic Theory&Research,Consumption
Politically Acceptable Trade Compromises Between The EC and The US: A Game Theory Approach
No full textA model is developed to quantify the special status of agriculture in the US and the EC trade negotiations. The role of special interests are measured by a policy goals function (PGF) whose weights are estimated for each special interest group. The analysis searches for mutually acceptable, mutually advantageous trade agreements between the US and the EC using a partial equilibrium world trade model coupled with game theory. Results suggest that it is in the best interest of the US (resp. EC) 'for the EC (resp. US) to liberalize whi1e the other follows the status quo policies of 1986. Mutual gains in PGF values to both countries pursuing "large" liberalizations are unlikely to exist, although "small" liberalizations may give rise to "small" mutual gains. Altering each country's action space, and permitting compensatory payments to the most influencial groups yields trade liberalization, but free trade does not result.game theory, trade liberalization, trade negotiations, International Relations/Trade,
The Singer or the Song? Developments in Performers' Rights from the Perspective of a Cultural Economist
No full textOver the last century, performers gradually acquired statutory protection of their economic and moral
rights. These rights are not copyright in the legal sense but neighboring rights and until recently, they
were mainly remuneration rights that are collectively administered. With the WPPT (WIPO
Performers and Phonograms Treaty), performers now have individual exclusive rights for digital
performances; this leads to the question: what has motivated this change – is it a change in the
perception of the value of performer or a change brought about by the changing technology of copying or,
indeed, a change that reflects different economic costs and benefits? The paper discusses the role of
copyright law as an incentive to performers and asks if the economic role of the performer is so different
from that of the author. The conclusion is that a complex interaction of the legal regulations, economic
conditions and institutional arrangements for administering these new rights will determine the outcome
The etiology of esophageal cancer in high- and low- risk areas of Jiangsu province, China
No full text [Background]Esophageal cancer (EC) remains one of the most common and fatal malignancies worldwide. The geographic variation in EC occurrence is striking, and China is an area with one of the highest incidences of EC. A number of epidemiological studies have been conducted toward EC in the past decades, results suggested that tobacco smoking, alcohol drinking, unhealthy dietary factors and chronic injuries of the esophageal mucosa are important in the development of this disease. Genetic polymorphisms in enzymes involved in metabolism of carcinogens may also influence individual susceptibility. However, the effects of major lifestyle and hereditary risk factors on the development of EC remain poorly understood in China. Moreover, little attention has been paid to the etiological heterogeneity between similar areas with great risk gradient. [Methods]From 2003 to 2007, a large population-based case-control study of EC has been conducted in a selected high-risk area and a selected low-risk area of Jiangsu Province, one of the highest cancer incidence areas in China. In total, 1,520 cases and 3,879 controls were recruited. In this thesis, we evaluated the role of major lifestyle factors such as tobacco smoking, alcohol drinking and dietary factors, as well as inherited determinants including family history of cancer and genetic polymorphisms of alcohol-metabolizing related genes on the risk of EC. In addition, we investigated how much of the risk gradient between two areas could be explained by variation in the distributions of major risk factors. [Results] Tobacco smoking and alcohol drinking moderately increased the risk of EC, while the positive associations were only found among men but not among women. Dietary factors were observed to play important roles in the development of EC. Specific dietary habits i.e., fast eating speed, and hot eating and/or drinking substantially elevated EC risk and could explain more than 20% of EC cases each. High intake of salty foods and fried foods, low consumption of raw garlic were also observed to increase the risk of EC. In addition to environmental and lifestyle factors, we confirmed that a positive family history can significantly increase EC risk, and found the inheritance may modify the effect of some unhealthy lifestyles. Moreover, we further explored the relationship between EC and single nucleotide polymorphismsof ADH1B, ADH1C and ALDH2 genes. Results showed that the slow metabolizing ADH1B G allele, ADH1C G allele and ALDH2 A allele significantly increased EC risk among moderate-to-heavy alcohol drinkers, and a significant interaction was observed between ALDH2 gene and alcohol consumption. Lastly, we found that more than 60% of EC cases could be attributable to major lifestyle risk factors in the study population; furthermore, dissimilar distribution of several lifestyle factors, together with variations of hereditary factors may be largely responsible for the incidence difference between two study areas. [Conclusion]The findings in this thesis confirm that unhealthy lifestyles including smoking, alcohol drinking and some dietary factors are the predominant risk factors of EC in China, and a large proportion of incidence difference between regions at varying risk could be attributed to the different prevalence of lifestyle factors. As most of the identified risk factors are modifiable, these could be translated into risk reduction prevention programs in China, and a substantial proportion of new EC cases are expected to be prevented by eliminating or avoiding these risk factors in the population. </p
Specific amino acid substitutions in the S protein prevent its excretion in vitro and may contribute to occult hepatitis B virus infection
No full textOccult hepatitis B virus (HBV) infection (OBI) is defined as low plasma level of HBV DNA with undetectable HBV surface antigen (HBsAg) outside the pre-seroconversion window period. The mechanisms leading to OBI remain largely unknown. The potential role of specific amino acid substitutions in the S protein from OBI on HBsAg production and excretion was examined in vitro. HBsAg was quantified in culture supernatants and cell extracts of HuH-7 cells transiently transfected with plasmids containing the S gene of eight HBsAg+ controls and 18 OBI clones. The intracellular (IC)/extracellular (EC) HBsAg production ratio was ?1.0 for the majority of controls. Three IC/EC HBsAg patterns were observed in OBI strains clones: pattern 1 defined as IC/EC ratio 1.0 in 5/18 OBI clones; pattern 2 with detectable IC but low or undetectable EC HBsAg (IC/EC: 7.0-800) in 6/18 OBIs; and pattern 3 with both low or undetectable IC and EC HBsAg in 7/18 clones. Intracellular immunofluorescence staining showed that, in pattern 2, HBsAg was concentrated around the nucleus suggesting retention in the endoplasmic reticulum. Substitutions M75T, Y100S or P178R were present in 4/6 pattern 2 OBI clones. Site-directed mutagenesis-corrected mutations reversed HBsAg excretion to pattern 1 and, when introduced in a control clone, induced pattern 2 except for Y100S. In a control and several OBIs, variants of a given quasispecies expressed HBsAg according to different patterns. However, the P178R substitution present in all cloned sequences of two OBI strains may contribute significantly to the OBI phenotype.</p
The Impact of Changes in Regulatory and Market Environment on Sustainability of Wine Producers: A Structural Equation Model
No full textWe explore the farmers’ perception of how different external drivers of changes in farming activities could lead to sustainability practices among wine producers. The general assumption is that regulatory and market forces can change the production strategies of wine producers, which could eventually lead to the adoption of sustainability practices. We presented the percentage sustainability practice (PSP) as a novel way of measuring sustainability. We developed a structural equation model (SEM) with 13 hypotheses to test our assumption for the wine supply chain in Tuscany (Italy). Among the market forces, we found that wine growers perceived access to credit to have a significant positive association with sustainability practices. We also found that the perception of change in regulatory instruments such as environmental regulation and Common Agriculture Policy can lead to sustainable practice if they improve access to credit. Our research provides evidence for medium-large scale wine producers, emphasising their role as carriers of innovation in the movement towards sustainable wine production
Specific amino acid substitutions in the S protein prevent its excretion in vitro and may contribute to occult hepatitis B virus infection
No full textOccult hepatitis B virus (HBV) infection (OBI) is defined as low plasma level of HBV DNA with undetectable HBV surface antigen (HBsAg) outside the pre-seroconversion window period. The mechanisms leading to OBI remain largely unknown. The potential role of specific amino acid substitutions in the S protein from OBI on HBsAg production and excretion was examined in vitro. HBsAg was quantified in culture supernatants and cell extracts of HuH-7 cells transiently transfected with plasmids containing the S gene of eight HBsAg+ controls and 18 OBI clones. The intracellular (IC)/extracellular (EC) HBsAg production ratio was ?1.0 for the majority of controls. Three IC/EC HBsAg patterns were observed in OBI strains clones: pattern 1 defined as IC/EC ratio 1.0 in 5/18 OBI clones; pattern 2 with detectable IC but low or undetectable EC HBsAg (IC/EC: 7.0-800) in 6/18 OBIs; and pattern 3 with both low or undetectable IC and EC HBsAg in 7/18 clones. Intracellular immunofluorescence staining showed that, in pattern 2, HBsAg was concentrated around the nucleus suggesting retention in the endoplasmic reticulum. Substitutions M75T, Y100S or P178R were present in 4/6 pattern 2 OBI clones. Site-directed mutagenesis-corrected mutations reversed HBsAg excretion to pattern 1 and, when introduced in a control clone, induced pattern 2 except for Y100S. In a control and several OBIs, variants of a given quasispecies expressed HBsAg according to different patterns. However, the P178R substitution present in all cloned sequences of two OBI strains may contribute significantly to the OBI phenotype.</p
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