6,190 research outputs found
What would Dr. James Parkinson think today? The 21st Annual Congress of the International Parkinson's disease and movement disorders society
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Motor complications in Parkinson's disease: Striatal molecular and electrophysiological mechanisms of dyskinesias
No full textLong-term levodopa (l-dopa) treatment in patients with Parkinson ́s disease (PD) is associated with the development of motor complications (ie, motor fluctuations and dyskinesias). The principal etiopathogenic factors are the degree of nigro-striatal dopaminergic loss and the duration and dose of l-dopa treatment. In this review article we concentrate on analysis of the mechanisms underlying l-dopa-induced dyskinesias, a phenomenon that causes disability in a proportion of patients and that has not benefited from major therapeutic advances. Thus, we discuss the main neurotransmitters, receptors, and pathways that have been thought to play a role in l-dopa-induced dyskinesias from the perspective of basic neuroscience studies. Some important advances in deciphering the molecular pathways involved in these abnormal movements have occurred in recent years to reveal potential targets that could be used for therapeutic purposes. However, it has not been an easy road because there have been a plethora of components involved in the generation of these undesired movements, even bypassing the traditional and well-accepted dopamine receptor activation, as recently revealed by optogenetics. Here, we attempt to unify the available data with the hope of guiding and fostering future research in the field of striatal activation and abnormal movement generation. © 2017 International Parkinson and Movement Disorder Society
FINANCING COMMUNITY FACILITIES: A CASE STUDY OF THE PARKS AND RECREATIONAL GENERAL OBLIGATION BOND MEASURE OF SAN JOSE, CALIFORNIA
No full textThis study of the City of San Jose’s Parks and Recreation General Obligation (GO) Bond Measure seeks to identify the politics-, management-, and planning-related lessons learned by the City as it developed its community facilities using the GO bonds proceeds. The study finds that these lessons include: be conservative in what you promise the residents; be prepared for changes in economic environment by identifying supplementary funding sources should the primary source not yield adequate funds; make sure that the jurisdiction is organizationally capable of handling the increased workload; and prepare detailed project plans prior to the bond issuance.Community Infrastructure and Services; Municipal Bonds; Public Finance
Jose Maria Alvarez Biographical Sketch and Commentary - Accession 171 - M76 (92-94)
No full textThe Jose Maria Alvarez Papers consist of a paper titled “Conversaciones con Jose Maria Alvarez” by Juan Miguel Margalef in collaboration with Jesus Munarriz and Csaba Csuday. Alvarez is a Spanish author and historian who has written articles, books, movie scripts and poetry. The paper contains biographical information concerning Alvarez as well as comments on his writing. The paper is written in Spanish.https://digitalcommons.winthrop.edu/manuscriptcollection_findingaids/1304/thumbnail.jp
SARS-CoV-2 and the risk of Parkinson's disease: facts and fantasy.
No full textDuring the pandemic it has become clear that severe acure respiratory syndrome coronavirus (SARS-CoV-2) causes not just respiratory disease, but can affect multiple organs and tissues. Of note is the involvement of the CNS and PNS, and the fact that this involvement is independent from the severity of the respiratory disease. Acute and subacute neurological complications of SARS-CoV-2 infections are reported in up to 85% of patients, including those with severe COVID-19, but also in otherwise minimally symptomatic or asymptomatic people. As many as 65% of people with COVID-19 present with hyposmia, which is also a common premotor symptom in Parkinson’s disease. This symptom, added to the fact that parkinsonism has been reported following COVID-19, has drawn the attention of the medical community to the hypothetical link between SARS-CoV-2 infection and Parkinson’s disease.Fil: Merello, Marcelo Jorge. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bhatia, Kailash P.. No especifíca;Fil: Obeso, Jose A.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentin
Dr. Jose Franco Rodriguez & - The Gift of Bicameral Mentality in Lake Atitlan\u27s Mayan Ora
No full textDr. Jose Franco Rodriguez and speaks at the Chesnutt Library of Fayetteville State University about their recent research Of Gods And Men- The Gift of Bicameral Mentality in Lake Atitlan\u27s Mayan Ora.
Presented live on March 5, 2025 as part of Chesnutt Library\u27s Faculty Author Series.https://digitalcommons.uncfsu.edu/faculty_author/1012/thumbnail.jp
Jose Miguel Ramos Arispe
No full textPhotograph shows an engraving of Jose Miguel Ramos Arispe, considered the Father of Mexican Federalism and author of the 1824 Mexican Constitution
Maxillary lateral incisor agenesis and its relationship to overall tooth size
No full textStatement of problem: Agenesis of the maxillary lateral incisor is linked to differences in overall tooth size. Thus, the mesio-distal space required for final esthetic restoration in patients with missing one of both maxillary lateral incisors may be smaller.
Purpose. The purpose of this study is to determine if a tooth size discrepancy exists in orthodontic patients with agenesis of the maxillary lateral incisor(s).
Material and methods. Forty sets of dental casts from white orthodontic patients (19 male and 21 female) mean age 15.9 years were collected. All casts had agenesis of one or both maxillary lateral incisors. The teeth were measured with a digital caliper at their greatest mesio-distal width and then compared to a control group matched for ethnicity, age and sex. S One-way repeated measures ANOVA (α=.05) was used for statistical analysis.
Results. Males in the test group had significantly smaller maxillary posterior teeth when compared to males in the control group, with differences ranging from 0.28-0.78mm. Females showed significantly smaller maxillary anterior teeth, with differences ranging from 0.22-0.42mm. The remaining maxillary lateral incisor was also significantly smaller (1.27mm difference) in the male and female unilateral agenesis test groups indicating higher incidence of ‘peg’ laterals when compared to the control group.
Conclusions. Agenesis of one or both maxillary lateral incisors is associated with a tooth size discrepancy. White males experienced smaller than normal posterior maxillary teeth and females showed smaller anterior maxillary teeth.This article is based on the Master’s thesis (J.W.) presented in 2011 in partial fulfilment of requirements for the degree of Master of Science, Marquette University School of Dentistry, 2011.Peer reviewe
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