199,177 research outputs found
Paolo Orsi e la necropoli di Torre Galli
No full textSintetico resoconto delle ricerche condotte da Paolo Orsi nella necropoli protostorica calabrese di Torre Gall
Post-M&A absorption-related invention capacity in the biopharmaceutical industry.
No full textRecognizing the importance of external knowledge flows is fundamental in sectors characterized by dynamic information and strong intellectual property rights (Chesbrough, 2003). Consequently, firms have progressively forsaken the idea that new knowledge has to be generated through internal processes (Arora et al., 2001; Gans and Stern, 2003) and have begun considering external knowledge appropriation. From this perspective, strategic alliances and mergers and acquisitions (M&As) are alternative organizational forms that, besides being renowned for their ability to promote entry into new markets and their effectiveness to achieve economies of scale and scope, have progressively become efficient means to access and assimilate knowledge from other organizations (De Man and Duysters, 2005)
The ELBA force field for coarse-grain modeling of lipid membranes
No full textA new coarse-grain model for molecular dynamics simulation of lipid membranes is presented. Following a simple and conventional approach, lipid molecules are modeled by spherical sites, each representing a group of several atoms. In contrast to common coarse-grain methods, two original (interdependent) features are here adopted. First, the main electrostatics are modeled explicitly by charges and dipoles, which interact realistically through a relative dielectric constant of unity (?r=1). Second, water molecules are represented individually through a new parametrization of the simple Stockmayer potential for polar fluids; each water molecule is therefore described by a single spherical site embedded with a point dipole. The force field is shown to accurately reproduce the main physical properties of single-species phospholipid bilayers comprising dioleoylphosphatidylcholine (DOPC) and dioleoylphosphatidylethanolamine (DOPE) in the liquid crystal phase, as well as distearoylphosphatidylcholine (DSPC) in the liquid crystal and gel phases. Insights are presented into fundamental properties and phenomena that can be difficult or impossible to study with alternative computational or experimental methods. For example, we investigate the internal pressure distribution, dipole potential, lipid diffusion, and spontaneous self-assembly. Simulations lasting up to 1.5 microseconds were conducted for systems of different sizes (128, 512 and 1058 lipids); this also allowed us to identify size-dependent artifacts that are expected to affect membrane simulations in general. Future extensions and applications are discussed, particularly in relation to the methodology's inherent multiscale capabilities
Éloge funèbre de M. Paolo Orsi, associé étranger de l'Académie
No full textCoville Alfred. Éloge funèbre de M. Paolo Orsi, associé étranger de l'Académie. In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 80ᵉ année, N. 1, 1936. pp. 17-19
Éloge funèbre de M. Paolo Orsi, associé étranger de l'Académie
No full textCoville Alfred. Éloge funèbre de M. Paolo Orsi, associé étranger de l'Académie. In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 80ᵉ année, N. 1, 1936. pp. 17-19
Recensione a M. Ciccuto, L.M. Livraghi (a cura di), Dante visualizzato. Carte ridenti II: XV secolo. Prima parte (Firenze, Franco Cesati Editore, 2019)
No full textRecesione a M. Ciccuto, L.M.G. Livraghi (a cura di), Dante visualizzato. Carte ridenti II: XV secolo. Prima part
Post M&A absorption related invention capacity in the biopharmaceutical industry
No full textRecognizing the importance of external knowledge flows is fundamental in sectors characterized by dynamic information and strong intellectual property rights (Chesbrough, 2003). Consequently, firms have progressively forsaken the idea that new knowledge has to be generated through internal processes (Arora et al., 2001; Gans and Stern, 2003) and have begun considering external knowledge appropriation. From this perspective, strategic alliances and mergers and acquisitions (M&As) are alternative organizational forms that, besides being renowned for their ability to promote entry into new markets and their effectiveness to achieve economies of scale and scope, have progressively become efficient means to access and assimilate knowledge from other organizations (De Man and Duysters, 2005)
The Urban Development of Campi Flegrei, Italy
No full textSince the Late Pleistocene, Campi Flegrei have been inhabited by humans because of the region's soil fertility, mild climatic conditions, and both commercially and strategically advantageous position in the Mediterranean basin. After a period of frequent eruptions that affected the environment and forced indigenous farmers temporarily to abandon the area after each event, in 740 BC Campi Flegrei were chosen by Chalcidian Greeks from Ischia to establish the settlement of Cuma, which was the first Greek colony in what is today the Italian mainland. Since its earliest colonisation, the Phlegraean area, because of its location and environmental characteristics, has been a cause of conflicts over its control, and has also witnessed a significant increase in population and urban development. Even the threat of ongoing bradyseismic activity, which has caused seismicity and ground deformation, and the AD 1538 Monte Nuovo eruption did not discourage people from living in the area. Campi Flegrei have undergone socio-economic development which for most of its history has been sustainable. Only with industrialisation over recent decades, has it become unsustainable. This unsustainable development has also caused an increase in the vulnerability of the area in terms of its volcanic risk. Knowledge of the history of urbanisation in Campi Flegrei may, therefore, assist the civil authorities in effecting socio-economic policies aimed at disaster risk reduction
Acceleration of Coarse Grain Molecular Dynamics on GPU Architectures
No full textCoarse grain (CG) molecular models have been proposed to simulate complex sys- tems with lower computational overheads and longer timescales with respect to atom- istic level models. However, their acceleration on parallel architectures such as Graphic Processing Units (GPU) presents original challenges that must be carefully evaluated. The objective of this work is to characterize the impact of CG model features on parallel simulation performance. To achieve this, we implemented a GPU-accelerated version of a CG molecular dynamics simulator, to which we applied specic optimizations for CG models, such as dedicated data structures to handle dierent bead type interac- tions, obtaining a maximum speed-up of 14 on the NVIDIA GTX480 GPU with Fermi architecture. We provide a complete characterization and evaluation of algorithmic and simulated system features of CG models impacting the achievable speed-up and accuracy of results, using three dierent GPU architectures as case studie
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