1,721,122 research outputs found
Sentinel node biopsy
No full textKrag et al. (Oct. 1 issue)1 present interesting data on the use of probe-guided resection of radioactive sentinel nodes in patients with breast cancer, but they conclude that “the procedure can be technically challenging, and the success rate varies according to the surgeon.” In our opinion, preoperative lymphoscintigraphy can facilitate surgical localization and excision of the sentinel node and increase the detection rate.
Lymphoscintigraphy is a nuclear-medicine procedure that is easy to perform and, in conjunction with the intraoperative gamma probe, has been successfully used primarily in patients with malignant melanoma or breast cancer.2,3 The main advantage of this imaging technique is that it allows accurate preoperative localization of the sentinel node; after scintigraphic images have been obtained, a mark can be made on the skin that corresponds to the first lymph node detected by the gamma camera, thereby indicating precisely where the incision should be made. The use of the gamma probe during surgery then guides dissection, making the node biopsy easier and consistently successful. In most patients, the sentinel node is visible within 30 minutes after the injection, regardless of the size of the radiolabeled particles used, when they are injected subdermally.4 Lymphoscintigraphy is not time-consuming; anterior and lateral views, each obtained within five minutes, are sufficient to identify another 10 percent of sentinel nodes that might have not been detected with the use of a probe survey alone.
Role of technetium-99m tetrofosmin SPECT imaging in the examination of patients with breast lesions
No full text
Indium-111 pentetreotide scintigrapy in the detection of insulinomas: importance of SPECT imaging
No full textJ Nucl Med. 2000 Mar;41(3):459-62.
111In-pentetreotide scintigraphy in the detection of insulinomas: importance of SPECT imaging.
Schillaci O, Massa R, Scopinaro F.
SourceDepartment of Sciences and Biomedical Technologies, University of L'Aquila, Rome, Italy.
Abstract
The aim of this study was to determine whether the systematic use of SPECT can increase the reported low sensitivity of somatostatin receptor scintigraphy (SRS) in detecting insulinomas.
METHODS: Fourteen patients were evaluated. After 111In-pentetreotide injection (approximately 250 MBq intravenously), abdominal SPECT images were obtained at 4 h and multiple planar images were obtained at 4 and 24 h. MRI and CT were performed within 1 mo of SRS. Sixteen tumors were histologically verified after surgery in 14 patients.
RESULTS: SPECT revealed 14 lesions in 12 patients (sensitivity, 87.5%), both planar SRS and MRI revealed 7 tumors in 7 patients (sensitivity, 43.8%), and CT revealed only 5 lesions in 4 patients (sensitivity, 31.3%). Moreover, in 4 patients SPECT was the only examination with positive findings.
CONCLUSION: SPECT at 4 h is mandatory for preoperative detection of insulinomas using SRS because the images are more sensitive than planar images and are superior to images from other conventional methods.
PMID:10716319[PubMed - indexed for MEDLINE] Free full tex
Transitional cell carcinoma of the bladder: Radioimmuodetection with 99mTc antiepithelial growth factor receptor antibodies
No full textCorrection to: Predictive and prognostic value of 18F-DOPA PET/CT in patients affected by recurrent medullary carcinoma of the thyroid (Annals of Nuclear Medicine, (2018), 32, 1, (7-15), 10.1007/s12149-017-1213-0)
No full textThe following affiliation should be added to the authors Agostino Chiaravalloti and Orazio Schillaci
99mTc sestamibi single-photon emission tomography detects subclinical myocardial perfusion abnormalities in patients with systemic lupus erytematosus
No full textTechnetium-99m sestamibi single-photon emission tomography detects subclinical myocardial perfusion abnormalities in patients with systemic lupus erythematosus.
Schillaci O, Laganà B, Danieli R, Gentile R, Tubani L, Baratta L, Scopinaro F.
SourceNuclear Medicine, University of L'Aquila, Italy.
Abstract
In patients with systemic lupus erythematosus, involvement of the cardiovascular system is the third leading cause of death. However, although autopsy studies have demonstrated a high incidence of abnormalities in both the myocardium and coronary vessels, clinical manifestations have been reported in only a small percentage of cases. The aim of this study was to evaluate myocardial perfusion in asymptomatic lupus patients using technetium-99m sestamibi single-photon emission tomography (SPET). Twenty-eight patients without overt cardiac involvement and risk factors were studied with 99mTc-sestamibi SPET at rest and after dipyridamole infusion. Perfusion abnormalities were detected in 18 cases: six had persistent defects, three had reversible defects, seven had both persistent and reversible defects, and two showed rest defects which normalized on dipyridamole images ("reverse redistribution pattern"). Coronary angiography was performed in eight patients with positive 99mTc-sestamibi SPET, and showed normal epicardial vessels in all the cases. These results indicate that 99mTc-sestamibi SPET reveals a high prevalence (18 out of 28 patients in this study, i.e. 64%) of myocardial perfusion abnormalities in asymptomatic lupus patients, probably due to the primary immunological damage of this autoimmune disease. In conclusion, rest/dipyridamole 99mTc-sestamibi SPET can be a useful non-invasive method to identify subclinical myocardial involvement in systemic lupus erythematosus, and patients potentially at risk of later cardiac events.
PMID:10398819[PubMed - indexed for MEDLINE
Technetium-99m tetrofosmin single photon emission computed tomography in the evaluation of suspected lung cancer
No full textTechnetium-99m-tetrofosmin is a radiopharmaceutical employed for myocardial imaging, which has recently emerged as useful in the visualization of tumours. In this study technetium-99m-tetrofosmin was evaluated for its accuracy in differentiating malignant from benign pulmonary lesions, and in detecting mediastinal node metastasis due to lung cancer. Eighty-one patients with a solitary lung lesion on the chest radiograph and/or CT scan were submitted to chest single photon emission computed tomography after technetium-99m-tetrofosmin injection (740 MBq i.v). The scintigraphic findings were correlated to the final histopathological diagnosis, demonstrating abnormal tracer accumulation in 51 of 54 malignant lesions (sensitivity 94% and in 4 out of 27 benign conditions (specificity 85%, yielding an accuracy of 91 % Mediastinal lymph-node involvement was evaluated in 35 patients with non small cell lung cancer who underwent mediastinoscopy and/or surgery. Tetrofosmin accuracy (89% was significantly higher than that of CT (69%, p < 0.05); the false negative scintigraphic results were in nodes sized less than 1 cm. In conclusion technetium-99m-tetrofosmin imaging is useful in distinguishing malignant om benign pulmonary lesions, and in non-invasively assessing mediastinal node metastases from non small cell lung cancer, especially in patients with enlarged nodes by CT scan
Hypoxia pathway: 18F-FAZA
No full textHypoxia plays a crucial role in various cellular events, including proliferation, survival, angiogenesis, immuno-surveillance, metabolism, as well as in tumour invasion and metastasis. This chapter will describe the current knowledge on technical procedures of radiosynthesis, features of biodistribution, and current research on potential clinical application of 18F-FAZA PET as a radiopharmaceutical agent able to assess the hypoxia expression in neoplastic cells
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