1,138 research outputs found
Primary hyperparathyroidism: imaging to pathology
No full text: The aim of this review is to describe the multimodal imaging (ultrasound, magnetic resonance, computed tomography, and nuclear medicine) of primary hyperparathyroidism and its correlation to the pathological findings. In the last decades, imaging science has progressed a great deal. Accurate preoperative localization of the involved glands is essential for surgical success
Paraneoplastic hypocalcemia-induced heart failure in advanced breast cancer: A case report and literature review
No full textHypocalcemi a is an uncommon clinical symptom of patients with malignant tumors, and a number of factors may be involved in its development. The present study describes the case of a 67-year-Old Caucasian female, presenting with severe refractory hypocalcemia and heart failure. The patient was subsequently diagnosed with breast cancer and bone metastases. The paraneoplastic origin of the syndrome was confirmed by its complete resolution once the tumor responded to specific anti neoplastic treatments, comprising weekly paclitaxel and aromatase inhibitor administration. The present case report suggested the need for greater awareness of the possibility of paraneoplastic hypocalcemia in breast cancer patients, and suggested that this condition may also contribute to the occurrence of heart failure. The mechanisms potentially responsible for this event were discussed and a brief review of the literature presented
The Devil and the Jews The Medieval Conception of the Jew and Its Relation to Modern Anti-Semitism
No full textA JPS bestseller, this is the definitive work of scholarship on the medieval conception of the Jew as devil-literally and figuratively. Through documents, analysis, and illustrations, the book exposes the full spectrum of the Jew's demonization as devil, sorcerer, and ritual murderer. The author reveals how these myths, many with origins traced to Christian Europe in the late Middle Ages, still exist in transmuted form in the modern era.Front Cover -- Title Page -- Dedication -- Copyright Page -- Contents -- List of Illustrations -- Foreword by Marc Saperstein -- Preface -- Introduction: Medieval Superstition and Modern Antisemitism -- Part One: The "Demonic" Jew -- I. "Devil Incarnal" -- II. Antichrist -- III. With Horns and Tail -- Part Two: The Jew as Sorcerer -- IV. "A Jew is Full of Sorcery" -- V. Europe Discovers the Kabbalah -- VI. Magic and Medicine -- VII. The Poisoners -- VIII. Host and Image Desecration -- IX. Ritual Murder -- X. The Blood Accusation -- Part Three: The Jew as Heretic -- XI. Church and Jew -- XII. Infidel or Heretic? -- XIII. The Attack Upon Usury -- XIV. The Crusade Against Sorcery -- XV. Heretic-Sorcerer-Jew -- Epilogue. Still The Devil's Own -- Notes -- Bibliography -- Index -- Back CoverA JPS bestseller, this is the definitive work of scholarship on the medieval conception of the Jew as devil-literally and figuratively. Through documents, analysis, and illustrations, the book exposes the full spectrum of the Jew's demonization as devil, sorcerer, and ritual murderer. The author reveals how these myths, many with origins traced to Christian Europe in the late Middle Ages, still exist in transmuted form in the modern era.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Separate episodes of capillary leak syndrome and pulmonary hypertension after adjuvant gemcitabine and three years later after nab-paclitaxel for metastatic disease
No full textBackground: Systemic capillary leak syndrome is a rare disease with a high mortality rate. This syndrome is characterised by generalised edema, hypotension, hemoconcentration, and hypoproteinemia. The cause is the sudden onset of capillary hyperpermeability with extravasations of plasma from the intravascular to the extravascular compartment. We present the case of a patient who experienced two episodes of systemic capillary leak syndrome and pulmonary hypertension; the first after gemcitabine in an adjuvant setting and the second three years later after treatment with nab-paclitaxel for metastatic disease.Case presentation: A 65-year-old patient underwent a pancreatectomy in January 2010 for ductal carcinoma (pT3 N0 M0, stage IIa), followed by adjuvant chemotherapy. Seven days after the last cycle, she developed dyspnea associated with orthopnea and cough. A transthoracic cardiac ecocolordoppler was performed, with evidence of pulmonary hypertension (58 mmHg). Blood tests showed an increase in creatinine, pro-BNP and D-Dimer. She began high-dose diuretic therapy combined with cortisone. After a month, the patient was eupneic and the anasarca had resolved. We decided gradually to reduce the steroid and diuretic therapy. After ten days of the reduction, the patient began to re-present the same symptoms after treatment with gemcitabine. Corticosteroid therapy was restored with rapid clinical benefit and decreased pro-BNP after a week of treatment. After two years, the disease returned. As a first line treatment, it was decided to use nab-paclitaxel 100 mg/m2 weekly. After two doses, followed by approximately 14 days of treatment, the patient developed acute respiratory distress syndrome. The clinical suspicion was a relapse of capillary leak syndrome and treatment with a high-dose diuretic (furosemide 250 mg daily) was started combined with cortisone (40 mg methylprednisolone). The patient showed a progressive clinical benefit.Conclusions: In patients treated with gemcitabine and nab-paclitaxel who experience a sudden onset of diffuse edema with respiratory distress, capillary leak syndrome should be suspected. Immediate treatment with corticosteroids may be life-saving. © 2013 Casadei Gardini et al.; licensee BioMed Central Ltd
Acute hiatal hernia: a late complication following gastrectomy
No full textIntroduction. We describe a case of acute hiatal hernia during chemotherapy, in a female patient previously treated with gastrectomy. Case presentation. After gastric resection, the patient underwent chemotherapy, developing important emetic symptoms. A radiograph of the abdomen was performed because of acute epigastrial pain and it showed a marked left diaphragm elevation. A CT scan carried out 24 hours later identified an occlusion with herniation in the left hemi thorax. Subsequent surgical investigation resulted in a diagnosis of hiatal hernia with volvulus. Conclusions. This case represents a rare, late complication occurring after gastrectomy. © 2010 Piciucchi et al; licensee BioMed Central Ltd
Long-term complete response in a patient with liver metastases from breast cancer treated with metronomic chemotherapy
No full textBackground. Preclinical studies have shown that several chemotherapeutic agents at low doses may affect the vascular system. Here we report the case of a patient with long-term cancer control by metronomic chemotherapy. Case presentation. A 62-year-old woman with breast cancer underwent a left mastectomy in July 2007. For a liver metastasis she was given first-line chemotherapy with doxorubicin plus paclitaxel every 21 days. A CT scan after the sixth cycle showed a partial response. It was decided to stop the treatment with doxorubicin and paclitaxel, and start metronomic therapy with cyclophosphamide 50 mg daily orally and methotrexate 2.5 mg twice daily, 2 days a week. After 6 months of this maintenance treatment, CT scan showed a complete response. We examined the expression of vascular endothelial growth factor receptor 2 (VEGFR2) in histological sections of the primary tumor of our patient, finding evidence of overexpression of the receptor. The metronomic treatment is still ongoing, and after 60 months the patient maintains a complete response. Conclusion. This clinical case highlights how suitable metronomic chemotherapy can be used as maintenance therapy, allowing long-term treatment with no significant toxicity. This case suggests that the level of VEGFR2 is predictive of best response to antiangiogenic therapy
Dynamic contrast-enhanced ultrasonography (D-CEUS) for the early prediction of bevacizumab efficacy in patients with metastatic colorectal cancer
No full textObjectives: To investigate early changes in tumour perfusion parameters by dynamic contrast-enhanced ultrasonography (D-CEUS) and to identify any correlation with survival and tumour response in patients with metastatic colorectal cancer (CRC) treated with bevacizumab (B). Methods: Thirty-seven patients randomized to either chemotherapy (C) plus B or C alone were considered for this study. D-CEUS was performed at baseline and after the first treatment cycle (day 15). Four D-CEUS perfusion parameters were considered: derived peak intensity (DPI), area under the curve (AUC), slope of wash-in (A) and time to peak intensity (TPI). Results: In patients treated with C plus B, a ≥22.5 % reduction in DPI, ≥20 % increase in TPI and ≥10 % reduction in AUC were correlated with higher progression-free survival in the C+B arm (p = 0.048, 0.024 and 0.010, respectively) but not in the C arm. None of the evaluated parameter modifications had a correlation with tumour response or overall survival. Conclusions: D-CEUS could be useful for detecting and quantifying dynamic changes in tumour vascularity as early as 15 days after the start of B-based therapy. Although these changes may be predictive of progression-free survival, no correlation with response or overall survival was found. Key Points: • D-CEUS showed early changes in liver metastasis perfusion in colorectal cancer. • A decrease in tumour perfusion was associated with longer progression-free survival. • The decrease in perfusion was not correlated with higher overall survival
The azygos vein pathway: an overview from anatomical variations to pathological changes
No full text: The azygos venous system represents an accessory venous pathway supplying an important collateral circulation between the superior and inferior vena cava. The aim of this article is to revise the wide spectrum of changes ranging from normal to pathological conditions involving the azygos system. Teaching points • The azygos vein is a collateral venous pathway, becoming a vital shunt if major pathways of venous return are obstructed. • In azygos continuation, the azygos vein becomes significantly enlarged due to inferior vena cava interruption. • Fibrosing mediastinitis is an underestimated acquired disorder. • Fibrosing mediastinitis induces a variable engorgement of collateral veins. • Fibrosing mediastinitis leads to superior vena cava syndrome
Butcher Turned Devil
No full textDevil caught disguised as Santa Claushttps://egrove.olemiss.edu/kgbsides_uk/1356/thumbnail.jp
Polmone
No full textVengono descritte le diverse tecniche di studio.
Vengono valutate le patogie focali e diffuse del polmone come pure la patologia delle vie aeree.
Per quel che riguarda la valutazione dei noduli polmonari vengono descritte le diverse caratteristiche ed in particolare la valutazione dell'indice di accrescimento ed il contrast enhancement. Vengono poi descritti i cenni si semeiotica TC ed esaminate le caratteristiche delle seguenti patologie:
- Patologia focale benigna
. Amartoma
. Granulomi infiammatori
. Linfonodi intrapolmonari
. Malformazioni arterovenose
. Infarti polmonari
. Sequestro polmonare
. Atelettasia rotonda
- Patologia focale maligna
. Carcinoide
. Carcinoma broncogeno
. Metastas
- …
