1,720,976 research outputs found
Modificazioni morfologiche del tessuto sottocutaneo in corso di dolore muscolare sperimentalmente indotto ed in corso di edema cardiogeno: confronto fra gli aspetti ultrasonografici
No full textEffects of diflunisal on cutaneous sensory and pain thresholds
No full textThe analgesic activity of diflunisal was evaluated through the measurement of
cutaneous sensory and pain thresholds after electrical stimulation. Twelve
healthy volunteers were examined at baseline and five hourly intervals after oral
administration of 500 mg and 1 gm of diflunisal. The results showed that the
sensory threshold was not modified by diflunisal, but that the pain threshold was
significantly increased two and three hours after 500 mg of diflunisal and one,
two, and three hours after 1 gm of diflunisal. At two hours the pain threshold
was significantly higher after 1 gm than after 500 mg of diflunisal. It is
concluded that diflunisal produces an actual increase of the pain threshold in
healthy human subjects and that the amplitude, latency, and duration of its
effect are dose related
Aspetti morfologici del sottocutaneo in corso di sofferenza algogena sperimentalmente indotta:analisi ultrasonografica.
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Pancreatico-jejunal anastomosis in the treatment of chronic pancreatitis and calculosis of the Wirsung's duct
No full textIron as a catalyst of human low-density lipoprotein oxidation: Critical factors involved in its oxidant properties
No full textIron-induced human LDL oxidation, which is relevant to atherosclerosis, has not yet been properly investigated. We addressed such issue using iron(II) and (III) basically in the presence of phosphates, which are present in vivo and influence iron oxidative properties, at pH 4.5 and 7.4, representative, respectively, of the lysosomal and plasma environment. In 10mM phosphate buffered saline (PBS), iron(II) induces substantial LDL oxidation at pH 4.5 at low micromolar concentrations, while at pH 7.4 has low oxidative effects; iron(III) promotes small LDL oxidation only at pH 4.5. In 10mM sodium acetate/NaCl buffer, pH 4.5, iron-induced LDL oxidation is far higher than in PBS, highlighting the relevance of phosphates in the inhibitory modulation of iron-induced LDL oxidation. LDL oxidation is related to iron binding to the protein and lipid moiety of LDL, and requires the presence of iron(II) bound to LDL together with iron(III). Chemical modification of LDL carboxyl groups, which could bind iron especially at pH 4.5, decreases significantly iron binding to LDL and iron-induced LDL oxidation. Hydroxyl radical scavengers are ineffective on iron-induced LDL oxidation, which is inhibited by metal chelation, scavengers of alkoxyl/peroxyl radicals, or removal of LDL lipid hydroperoxides (LOOH). Overall, substantial human LDL oxidation is induced LOOH-dependently by iron(II) at pH 4.5 even in the presence of phosphates, suggesting the occurrence of iron(II)-induced LDL oxidation in vivo within lysosomes, where pH is about 4.5, iron(II) and phosphates coexist, plasma with its antioxidants is absent, and glutathione peroxidase is poorly expressed resulting in LOOH accumulation
Aspetti morfologici del sottocutaneo in corso di sofferenza algogena sperimentalmente indotta. Analisi ultrasonografica.
No full textModificazioni delle strutture somatiche conseguenti a patologia dolorosa post-traumatica del ginocchio
No full textDifferente percezione del dolore all'introduzione dell'ago nell' ambito dell'area iperalgesica in pori vuoti (ipoalgesici) ed in pori con bulbo pilifero (iperalgesici) in pazienti con sindromi dolorose croniche. Rilievo di un nuovo aspetto semeiologico dell'area iperalgesica
No full textComportamento della soglia algogena muscolare in relazione a differenti parametri di stimolazione
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