34 research outputs found
Pathogenic treatment of the inflammatory diseases of the urogenital tract in women of reproductive age
No full text
O.I. Letyaeva, O.R. Ziganshin
South Ural State Medical University, Chelyabinsk, Russian Federation
This paper discusses one of the important gynecological issues, inflammatory diseases of the urogenital tract caused by opportunistic microbes. The treatment and long-term control over these conditions are challenging and depend on their occurrence and high risk of complications. Impaired local anti-infectious protection is one of the risk factors of chronic inflammation. Since the disease may recur even after successful treatment, domestic and foreign authors increasingly focus on immunotherapy as a part of complex strategy and isolated entity. Local immunotherapy may prevent recurrences and activate host defense. This paper describes the management of two women with mixed infections. The first woman with chronic recurrent inflammation (cervicitis caused by U. urealyticum, vulvovaginal candidiasis, and aerobic vaginitis) in whom prior etiological therapy was ineffective received immunotherapy which resulted in long-term remission. The second woman with coexistent papillomavirus infection (genital warts) and bacterial vaginosis received immunotherapy and topical etiological treatment. As a result, clinical symptoms, the size and number of genital warts reduced which greatly facilitated their chemical destruction.
Keywords: genital tract, urogenital infections, papillomavirus infection, bacterial vaginosis, local immunity, biofilms.
For citation: Letyaeva O.I., Ziganshin O.R. Pathogenic treatment of the inflammatory diseases of the urogenital tract in women of reproductive age. Russian Journal of Woman and Child Health. 2021;4(1):59–64. DOI: 10.32364/2618-8430-2021-4-1-59-64.
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Urogenital trichomoniasis in women: state-of-the-art and treatment issues
No full textUrogenital trichomoniasis in women: state-of-the-art and treatment issues
O.I. Letyaeva, O.R. Ziganshin
South Ural State Medical University, Chelyabinsk, Russian Federation
Currently, sexually transmitted infections (STIs) and urogenital infections are an important clinical, epidemiological, and pharmacoeconomic issue of public health. Urogenital trichomoniasis is the most common STI caused by Trichomonas vaginalis, flagellar parasite which affects human urogenital tract. In 10% to 50% of patients with trichomoniasis infection is asymptomatic.
In women, major complications of trichomoniasis are pelvic inflammatory disease (i.e.m salpingoophoritis, endometritis, pelviperitonitis, cystitis, and pyelonephritis) and unfavorable effects on the pregnancy and its outcomes.
5-nitroimidazols are the only approved drug class for urogenital trichomoniasis.
Aim: To compare clinical microbiological efficacy of metronidazole and ornidazole for urogenital trichomoniasis in women.
Patients and Methods: 47 women aged 19–42 years with urogenital trichomoniasis were enrolled in this short-term open prospective randomized strudy. All patients were subdivided into two groups. 23 women (group I) received metronidazole 500 mg twice a day for 7 days. 24 women (group II) received ornidazole 500 mg twice a day for 5 days. Control group included 25 healthy women. Native smear microscopy, PCR, and ELISA were applied.
Results: Before treatment, all women reported on complaints of foul-smelling vaginal discharge, genital burning and itching. Clinical laboratory signs of inflammation, deep suppression of residential lactoflora, and significant increase in pro-inflammatory cytokine levels in vaginal discharge were revealed.
Conclusions: ornidazole 500 mg twice a day for 5 days has demonstrated high efficacy and safety for urogenital trichomoniasis in women of reproductive age. This medication provides more significant decrease in pro-inflammatory cytokine levels in vaginal discharge and do not suppress resident vaginal flora.
Keywords: Trichomonas vaginalis, urogenital trichomoniasis, proinflammatory cytokines, lactoflora, treatment, diagnosis, ornidazole, metronidazole.
For citation: Letyaeva O.I., Ziganshin O.R. Urogenital trichomoniasis in women: state-of-the-art and treatment issues. Russian Journal of Woman and Child Health. 2019;2(2):126–130.<br
Economic efficiency detoxication of therapy in complex treatment sick of the vulgar psoriasis
No full textМатусевич С.Л., кандидат медицинских наук, доцент, заведующий кафедрой кожных болезней, Тюменская государственная медицинская академия Росздрава (Тюмень).
Matusevich S.L., the candidate of medical sciences, the senior lecturer managing chair of skin diseases of Tyumen state medical academy Roszdrava (Tyumen). Зиганшин О.Р., доктор медицинских наук, профессор кафедры венерологии и дерматологии,
Челябинская государственная медицинская академия (Челябинск).
Ziganshin O.R., the doctor of medical sciences, the professor of chair of venereology and dermatology of the Chelyabinsk state medical academy (Chelyabinsk).Анализ экономической эффективности различных методов энтеральной детокеикационной терапии в комплексной терапии больных вульгарным псориазом показал целесообразность использования авторских методов лечения,
при которых максимальные значения экономической эффективности достигаются
при использовании лактулозы. The analysis of economic efficiency of various methods enteral detoxication in complex therapy sick of a vulgar psoriasis has shown to therapy expediency of use of author's methods of treatment at which the minimum values of economic efficiency are reached at use lactulose
National education of a harmoniously developed personality of younger generation: practical experience of the teacher and politician Sabir Shayakhmetovich Ziganshin
No full textIn this article, the author reveals an urgent problem of modern society and state – the formation of a harmoniously developed personality of younger generation. The author focuses on national education, which at the regional level contributes to the formation of such a model of personality. She gives specific definitions of the concept of «national education» by projecting this category through the past and modern parallels. As an example, she reveals the concept of national education, developed and practically implemented by an outstanding teacher and politician of the Republic of Bashkortostan in the 70-ies of the XX century Sabir Shayakhmetovich Ziganshin. Puts the following ideas into the basis of the national education of a harmoniously developed student's personality: the formation of a personality based on the historical past and culture of his people, folk pedagogy, knowledge and ability to use his native language in the process of communication, labor education, and the construction of the educational process through the integration of regular and extracurricular activities. The model of national education became the main foundations in the formation of the national-regional education system of Bashkortostan, which is relevant to this day, and requires reassessment by modern scientists and pedagogical community. Studying the phenomenon of national education of a harmoniously developed personality and the introduction of S.Sh. Ziganshin's pedagogical ideas today would be an important step in achieving the strategic objectives set for school education and society
Go to the identification of tissue-specific antibodies as markers of autoimmunity
No full textНагаева В.В., заведующая иммуноферментной лабораторией, Центральная медико-санитарная
часть № 15 Федерального медико-биологического
агентства России (г. Снежинск).
Nagayeva V.V., the Chairman of Immunoferment
Laboratory, Central Health Part № 15 Federal
Medical-Biological Agency of Russia (the town of
Snezhinsk). Елисеев Е.В., доктор биологических наук,
профессор, заведующий кафедрой спорта, туризма
и двигательной рекреации, Южно-Уральский государственный университет (г. Челябинск).
Eliseev E.V., Doctor Biological Sciences (Grand
ScD), Professor, Head of the Department of Sport,
Tourism and Physical Recreation, South Ural State
University (the city of Chelyabinsk). Зиганшин О.Р., доктор медицинских наук,
профессор, заведующий кафедрой дерматовенерологии, Челябинская государственная медицинская
академия.
Ziganshin O.R., Doctor of Medical Sciences
(Grand MD), Professor, Head of the Department of
dermatology, Chelyabinsk State Medical Academy.Поднимаются вопросы изучения аутоиммунного компонента патогенеза
при заболеваниях кожи у спортсменов с применением экспериментальной
тест-системы твердофазного иммуноферментного анализа. В результате исследования установлена четкая зависимость частоты проявления тканеспецифических антител от продолжительности заболевания. The work studied autoimmune component of
a pathogenesis rise at diseases of a skin at the athletes
with application of experimental test-system enzyme
immunoassay of analysis. In a findings of investigation
the precise dependence of frequency of exhibiting
specific of antibodies from duration of disease fixed
Dynamic and psychosomatic somatic and psychic indicator in the personal properties of athletes with atopic dermatitis
No full textЕлисеев Е.В., доктор биологических наук, профессор, заведующий кафедрой спорта, туризма и двигательной рекреации, Южно-Уральский государственный университет (г. Челябинск).
Eliseev E.V., Doctor Biological Sciences (Grand ScD), Professor, Head of the Department of Sport, Tourism and Physical Recreation, South Ural State
University (the city of Chelyabinsk). Зиганшин О.Р., доктор медицинских наук,
профессор, заведующий кафедрой дерматовенерологии, Челябинская государственная медицинская академия.
Ziganshin O.R., Doctor of Medical Sciences (Grand MD), Professor, Head of the Department of dermatology, Chelyabinsk State Medical Academy. Трегубова М.В., кандидат биологических наук, доцент кафедры спорта, туризма и двигательной
рекреации, Южно-Уральский государственный университет (г. Челябинск).
Tregubova M.V., Candidate of Biological Sciences (PhD), Associate Professor of the Department of Sport, Tourism and Physical Recreation, South Ural State University (the city of Chelyabinsk).Целью исследования являлось установление личностных психических
особенностей у спортсменов, страдающих атопическим дерматитом. В результате анализа психической структуры личности спортсменов с применением
современных психодиагностических компьютерных систем выявлена зависимость в соотношении частоты психопатологических синдромов и клинической
формы атопического дерматита. The aim of this study was to identify individual
personality disorders in sportsmen with atopic dermatitis. As a result of analysis of mental frame of the person of the sportsmen with application modern psychodiagnostic
of computer systems the dependence in the ratio frequencies of psychopathologic sets of symptoms and clinical form atopic dermatitis is revealed
Structurally functional components and mechanisms immunocorrection at treatmens of man citokin from urogenitaling infections
No full textНагаева В.В., заведующая иммуноферментной лабораторией ЦМСЦ-15 ФМБА России (Снежинск, Челябинская область). Тел.: 8-351-46-2-39-20. Nagaeva V.V., the chairman of immunЕлисеев Е.В., доктор биологических наук, профессор, заведующий кафедрой спорта, туризма и двигательной рекреации Южно-Уральского государственного
университета (Челябинск). Тел.: 8-351-267-99-54. Eliseev E.V., the doctor of biological science, the professor, the chairman of department of sport, tourism and moving recreation of South Ural State University (Chelyabinsk). Phone: 8-351-267-99-54.ofermenting laboratory CMSP-15 FMBA RF (Snezhinsk). Phone: 8-351-46-2-39-20. Зиганшин О.Р., доктор медицинских наук, профессор, ведущий специалист Челябинского областного кожно-венерологического диспансера (Челябинск). Тел.: 8-351- 261-24-02. Ziganshin O.R., the doctor of medical science, the professor, the leading expert of Chelyabinsk regional dermatovenerologic dispensary (Chelyabinsk). Тел.:8-351-261-24-02.Изучение иммунологических функций защитной деятельности организма позволяет описать механизмы иммунокоррекции иммунного ответа репродуктивного тракта мужчин при лечении их беталейкином и ронколейкином от урогенитальных инфекций различной этиологии. Studying immunologing functions of protective activity of an organism allows to describe mechanisms immunocorrection the immune answer of a reproductive
path of men at their treatment betaleukin and ronkoleukin from urogenetaling infections of a various etiology
Папилломавирусная инфекция у семейных пар. К обсуждению вопроса
No full textIn the Russian literature, insufficient attention is given to the study of the flow of human papillomavirus infection in couples. The aim of the study was to establish the frequency of infection with oncogenic HPV types and clinical manifestations of human papillomavirus infection in regular sexual partners. Surveyed 38 couples who are regular sexual partners in the past three years and denying unauthorized sex. PVI revealed at 70.9 per cent of women who had contact with an infected partner and 79.8 per cent of men. The average age for first sexual intercourse in women was 18.2 years, men - 16.7 years. 80% of men before marriage had more than 5 sexual partners. In 37 of 38 pairs of HPV types of high oncogenic risk coincide. The most frequently detected HPV type 16, are a few less - HPV 51, 31 and 39. Clinical manifestation of HPV infection among sexual partners of the 38 couples not identified, subclinical form of infection in women and men after colposcopy and peniscopy were found with equal frequency (18.4%) and (15,8%), respectively. The descriptions of peniscopy in men with HPV of high oncogenic risk was done.В отечественной литературе уделяется недостаточное внимание совместному изучению течения папилломавирусной инфекции (ПВИ) у семейных пар. Целью исследования явилось установление частоты инфицирования онкогенными типами вируса папилломы человека (ВПЧ) и характера клинических проявлений ПВИ у постоянных половых партнеров. Обследованы 38 пар, являющихся половыми партнерами в течение 3 и более лет и отрицающих посторонние половые контакты. ПВИ выявлена у 70,9% женщин, имевших контакт с инфицированным партнером, и у 79,8% мужчин. Средний возраст первого полового контакта у женщин составил 18,2 года, у мужчин - 16,7 года. 80% мужчин до брака имели более 5 половых партнеров. У 37 из 38 пар типы ВПЧ высокого онкогенного риска совпадали. Наиболее часто выявлялся ВПЧ 16-го типа, несколько реже - ВПЧ 51, 31 и 39. Клинически манифестная форма ПВИ у половых партнеров из 38 семейных пар не выявлена, субклиническая форма инфекции у женщин и мужчин после применения кольпоскопии и пенископии обнаруживалась с одинаковой частотой (18,4 и 15,8% соответственно). Приведены описания пенископии у мужчин, инфицированных ВПЧ высокого онкогенного риска
Особенности клиники и инструментальной диагностики инфекционной экземы
No full textOne of frequent forms of eczema is infectious (microbic) eczema, in recent years tending to heavier current. In certain cases differentiation between the endogenous eczema complicated by a piodermiya, and infectious eczema is difficult. The method of the stratified randomization chose 139 patients with infectious eczema and the 50 with endogenous eczema. Manifestations of a disease were compared clinically and by means of a dermatoskopia. At patients with infectious eczema reliable more often the itch had easy temper, only at this group there were a burning and morbidity. the centers of defeat weren’t symmetric and had a clear boundary. Dermatoskopic differences of infectious eczema were a clear boundary, brighter uneven coloring of the center, yellow inclusions, a mesh vascular network (red lines). Two clinical examples are given.Одной из частых форм экземы является инфекционная экзема, имеющая в последние годы тенденцию к более тяжелому течению. При отсутствии четких клинических критериев дифференциация между истинной экземой, осложненной пиодермией, и инфекционной экземой оказывается сложной. Целью работы явилась разработка дополнительных дифференциально-диагностических критериев инфекционной и истинной форм экземы на основе сравнения клинических проявлений и дерматоскопической картины заболевания. Методом стратифицированной рандомизации выбраны 139 больных инфекционной экземой и 50 - истинной экземой. Проявления заболевания сравнивали клинически и с помощью дерматоскопии. У больных инфекционной экземой достоверно чаще зуд имел легкий характер, только в этой группе присутствовали жжение и болезненность. Очаги поражения были несимметричны и имели четкие границы. Дерматоскопическими отличиями инфекционной экземы явились четкие границы, неравномерная яркая окраска очага, желтые включения, сетчатая сосудистая сеть (красные линии). Приведены два клинических примера. Для истинной экземы дерматоскопически характерны размытые контуры очага, равномерная окраска, сосудистая сеть в виде гломерулярных сосудов
