448 research outputs found
Pete Fackler
No full textThe Larson Studio Collection contains portraits and landscape photographs from Thomas Larson and his son O. Blaine Larson, who operated the Larson Studio in Provo, Utah County, Utah
Ken Fackler
No full textThe Larson Studio Collection contains portraits and landscape photographs from Thomas Larson and his son O. Blaine Larson, who operated the Larson Studio in Provo, Utah County, Utah
Mary Ann Fackler
No full textThe Larson Studio Collection contains portraits and landscape photographs from Thomas Larson and his son O. Blaine Larson, who operated the Larson Studio in Provo, Utah County, Utah
Pete Fackler (baby)
No full textThe Larson Studio Collection contains portraits and landscape photographs from Thomas Larson and his son O. Blaine Larson, who operated the Larson Studio in Provo, Utah County, Utah
The Gran Sasso National Laboratory
No full textThe status of the Gran Sass National Laboratory is here presented along with a short summary on the approved experimenta and their time schedule. It clearly shows the relevance that this laboratory may have in the next years
SARS-CoV-2 variants of concern display enhanced intrinsic pathogenic properties and expanded organ tropism in mouse models
No full textSARS-CoV-2 variants of concern (VOCs) display enhanced transmissibility and resistance to antibody neutralization. Comparing the early 2020 isolate EU-1 to the VOCs Alpha, Beta, and Gamma in mice transgenic for human ACE2 reveals that VOCs induce a broadened scope of symptoms, expand systemic infection to the gastrointestinal tract, elicit the depletion of natural killer cells, and trigger variant-specific cytokine production patterns. Gamma infections result in accelerated disease progression associated with increased immune activation and inflammation. All four SARS-CoV-2 variants induce pDC depletion in the lungs, paralleled by reduced interferon responses. Remarkably, VOCs also use the murine ACE2 receptor for infection to replicate in the lungs of wild-type animals, which induce cellular and innate immune responses that apparently curtail the spread of overt disease. VOCs thus display distinct intrinsic pathogenic properties with broadened tissue and host range. The enhanced pathogenicity of VOCs and their potential for reverse zoonotic transmission pose challenges to clinical and pandemic management
The History of Photography, the Materiality of the Medium and its Digital Dematerialization
No full textOn July 11, 2019, Katharina Fackler has published an article entitled “Of Stereoscopes and Instagram: Materiality, Affect, and the Senses from Analog to Digital Photography” in Open Cultural Studies. A Blog Post by Pablo Markin. In her paper, Katharina Fackler has explored how “photography has been “dematerialized” in the […] writings about photography from the early 19th to the 21st century to demonstrate […] the medium’s material, sensory, and affective valences” (519). This author, thus, ..
Inflation Forecast Targeting: A VAR Approach
No full textWe show how to implement inflation forecast targeting using a VAR model and derive the implied inflation-output variability frontier. Our approach is based on dynamic, stochastic simulations of the average inflation rate over a two-year horizon using the moving average representation of the VAR model. Using real time data over two samples, we estimate the inflation-output variability frontier for the U.S. and show that it has shifted favorably over time. We consider the frequency and nature of the policy interventions required to achieve target inflation in both samples and compare these interventions over time.
HIV-1 Nef Perturbs Artificial Membranes: Investigation of the Contribution of the Myristoyl Anchor
No full textAbstractNef, an accessory protein from human immunodeficiency virus type 1, is critical for optimal viral replication and pathogenesis. Here, we analyzed the influence of full-length myristoylated and nonmyristoylated Nef on artificial lipid bilayers composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC). By means of cosedimentation assays, we found that neither nonmyristoylated nor myristoylated Nef stably binds to POPC unilamellar vesicles. Time-resolved ellipsometry rather indicates that the proteins perturb the assembly of POPC planar bilayers. This observation was corroborated by fluorescence and scanning force microscopy, suggesting that membrane disordering occurs upon interaction of full-length myristoylated and nonmyristoylated Nef with planar POPC membranes immobilized on SiO2 surfaces resulting in loss of material from the surface. The membrane perturbations were further investigated by vesicle release experiments, demonstrating that the disordering results in defects through which the fluorophor carboxyfluorescein can pass. From these results, we conclude that Nef is capable of disordering and perturbing lipid membranes and that the myristoyl group is not the decisive determinant for the action of the protein on lipid membranes
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Status of neutrino mass experiments
No full textIn 1980 two experiments ignited a fertile field of research the determination of the neutrino masses. Subsequently, over 35 experiments using a variety of techniques have probed or are probing this question. Primarily I will discuss electron antineutrino (hereafter referred to as neutrino) mass experiments. However, let me begin in Section I to discuss astronomical and terrestrial observations which motivated these experiments. In Section II, I will quote limits from muon and tau mass determinations. These limits are more thoroughly discussed in other papers. I will continue by describing the four approaches used to measure the electron neutrino mass. In Section III, tritium beta decay mass determinations will be reviewed. This section includes a general summary of previous experimental results, and discussion of the major ongoing experiments. Section IV offers concluding remarks. 24 refs., 24 figs
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