1,721,294 research outputs found
Rheumatoid factor: a novel determiner in cancer history
Full text linkThe possible interplay between autoimmunity and cancer is a topic that still needs to be deeply explored. Rheumatoid factors are autoantibodies that are able to bind the constant regions (Fc) of immunoglobulins class G (IgGs). In physiological conditions, their production is a transient event aimed at contributing to the elimination of pathogens as well as limiting a redundant immune response by facilitating the clearance of antibodies and immune complexes. Their production can become persistent in case of different chronic infections or diseases, being for instance a fundamental marker for the diagnosis and prognosis of rheumatoid arthritis. Their presence is also associated with aging. Some studies highlighted how elevated levels of rheumatoid factors (RFs) in the blood of patients are correlated with an increased cancer risk, tumor recurrence, and load and with a reduced response to anti-tumor immunotherapies. In line with their physiological roles, RFs showed in different works the ability to impair in vitro anti-cancer immune responses and effector functions, suggesting their potential immunosuppressive activity in the context of tumor immunity. Thus, the aim of this review is to investigate the emerging role of RFs as determiners of cancer faith
Diagnostic corner: Ophthalmology [Corner diagnostico: oftalmologia]
No full textIl case report descrive l'aspetto clinico, l'evoluzione, l'iter diagnostico e la terapia di un'episclerite nodulare granulomatosa corneo-centrica in un cane di razza Golden retriever
Testing non-target organisms (NTO): step-wise tiered ecotoxicological or tiered ecological approach for plant protection products (PPPs)?
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Identificazione di B. bruxellensis, produttore di ammine biogene e fenoli volatili, in vini toscani e mosti in fermentazione
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Advances in the utilization of rhizobia in arid environments
No full textThere are numerous poorly known and unexploited rhizobia‐legume symbioses in arid ecosystems. These symbiotic associations have a considerable potential as sources for food, fodder, and energy. Expanded acquisition of information is needed on rhizobial strain specificities, salt and drought resistance, and on inoculation needs and applicable technologies for arid lands. Development of appropriate technologies for maximal protein recovery and for production of legume biomass as an energy source should be implemented. An important aspect is the utilization of molecular genetics for the development of economically improved legume symbioses
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