105,112 research outputs found
Irreparable rotator cuff tears: challenges and solutions
No full textMichele Novi,1 Avinash Kumar,2 Paolo Paladini,3 Giuseppe Porcellini,4 Giovanni Merolla3,5 1Orthopaedic and Trauma Unit, University Hospital of Pisa, Pisa, Italy; 2Department of Orthopaedics, All India Institute of Medical Sciences, Patna, India; 3Shoulder and Elbow Unit, “D. Cervesi” Hospital, AUSL della Romagna, Ambito Territoriale di Rimini, Rimini, Italy; 4Orthopaedic and Trauma Unit, University of Modena and Reggio Emilia, Policlinico di Modena, Modena, Italy; 5“Marco Simoncelli” Biomechanics Laboratory, “D. Cervesi” Hospital, AUSL della Romagna, Ambito Territoriale di Rimini, Rimini, Italy Abstract: Irreparable rotator cuff tears are common conditions seen by shoulder surgeons, characterized by a torn and retracted tendon associated with muscle atrophy and impaired mobility. Direct fixation of the torn tendon is not possible due to the retracted tendon and lack of healing potential which result in poor outcome. Several treatment options are viable but correct indication is mandatory for a good result, pain improvement, and restoration of shoulder function. Patient can be treated either with a conservative program or surgically when necessary, by different available modalities like arthroscopic debridement, partial reconstruction, subacromial spacer, tendon transfer, and shoulder replacement with reverse prosthesis. The aim of this study was to review literature to give an overview of the available possible solutions, with indications and expected outcomes. Keywords: irreparable rotator cuff tear, arthroscopy, partial repair, tendon transfer, graft augmentatio
The impact of G-protein-coupled receptor hetero-oligomerization on function and pharmachology
No full textAlthough highly controversial just a few years ago, the idea that G-protein-
coupled receptors (GPCRs) may undergo homo-oligomerization or
hetero-oligomerization has recently gained considerable attention. The
recognition that GPCRs may exhibit either dimeric or oligomeric structures
is based on a number of different biochemical and biophysical approaches.
Although much effort has been spent to demonstrate the mechanism(s) by
which GPCRs interact with each other, the physiological relevance of this
phenomenon remains elusive. An additional source of uncertainty stems
from the realization that homo-oligomerization and hetero-oligomerization
of GPCRs may affect receptor binding and activity in different ways,
depending on the type of interacting receptors. In this brief review, the
functional and pharmacological effects of the hetero-oligomerization of
GPCR on binding and cell signaling are critically analyzed
Radial head fractures: review of current evidence about assessment, classification and management
No full textThe radial head fractures are frequent elbow injuries with several fracture patterns and associated lesions. The literature highlights the importance of correct patient management right from the earliest stages to achieve the best results and to avoid complications. The purpose of this article was to provide an overview of current concepts of the management of radial head fractures. The main goal of each treatment should be to restore elbow biomechanics, kinematics and stability to achieve a complete range of motion and to early begin rehabilitation programs. For Mason type 1 fractures the nonoperative management is the best choice providing good or excellent results in most patients. There is less agreement regarding Mason type 2 fractures, in term of nonoperative or surgical treatment. When surgical treatment is chosen, open reduction and internal fixation seems to guarantee the best clinical outcomes with excellent results reported. The Mason type 3 or 4 fractures are managed with surgical treatment. However, the best method of treatment remains controversial in literature between open reduction and internal fixation, radial head arthroplasty and radial head excision. In the last years, arthroscopy is going to assume an important role in the management of elbow diseases, not only as diagnostic tool but also as surgical solution and probably in the future its role will become more and more relevant. Further studies with long-term follow-up are needed to determine the best form of treatment of these complex injuries. (Cite this article as: Tarallo L, Negri A, Novi M, Micheloni G, Keeling E, Porcellini G. Radial head fractures: review of current evidence about assessment, classification and management
Epistulae Novi Testamenti
No full textVorlageform der Veröffentlichungsangabe: Lipsiae Sumtibus I. B. G. FleischeriErschienen: 1 (1793) - 2 (1797
Versio Latina Epistolarum Novi Testamenti
No full textVorlageform des Erscheinungsvermerks: Lipsiae Sumtibus I. B. G. Fleischeri. MDCCLXXXXVII
Versio Latina Epistolarum Novi Testamenti
No full textVorlageform des Erscheinungsvermerks: Lipsiae Sumtibus I. B. G. Fleischeri. MDCCLXXXIII
Heterodimerization of G-protein-coupled receptor reveals an unexpected level of pharmacological diversity.
No full textPENGENDALIAN HAMA WALANG SANGIT PADA TANAMAN PADI MENGGUNAKAN INSEKTISIDA NABATI SKRIPSI Oleh Novi Pramitasari NIM. 061510401003 PROGRAM STUDI AGROTEKNOLOGI FAKULTAS PERTANIAN UNIVERSITAS JEMBER 2012
No full textRINGKASAN
Pengendalian Hama Walang Sangit Pada Tanaman Padi
Menggunakan Insektisida Nabati; Novi Pramitasari; 061510401003;
35 Halaman; Program Studi Agroteknologi Fakultas Pertanian Universitas
Jember.
Walang sangit merupakan hama yang sering merusak pada tanaman padi.
Serangan walang sangit menyebabkan kehilangan hasil mencapai 50 persen. Salah
satu altrenatif yang dapat digunakan adalah dengan insektisida nabati berbahan
dasar tanaman lidah mertua dan umbi gadung. Tanaman lidah mertua
mengandung saponin yang mudah larut dalam air dan mempunyai rasa pahit
menusuk. Saponin merupakan racun yang dapat menghancurkan butir darah, oleh
sebab itu saponin dapat digunakan sebagai pembasmi hama tertentu, sedangkan
umbi gadung diketahui diketahui mengandung dioskorin yang dapat menimbulkan
rasa pusing. Umbi mentahnya mengandung alkaloid sehingga dapat digunakan
sebagai bahan untuk racun binatang.
Penelitian ini dilakukan dengan tujuan untuk mengetahui efektivitas
tanaman lidah mertua dan umbi gadung sebagai insektisida nabati terhadap
walang sangit pada tanaman padi. Penelitian dilakukan di Antirogo mulai bulan
Maret sampai Mei 2012. Pengujian dilakukan menggunakan Rancangan Acak
Kelompok (RAK) dengan dua belas perlakuan. Kombinasi perlakuannya terdiri
dari: X0 (kontrol); X1 (ekstrak gadung dengan lidah mertua konsentrasi ( 90 g : 10
g )); X2 (ekstrak gadung dengan lidah mertua konsentrasi ( 80 g : 20 g )); X3
(ekstrak gadung dengan lidah mertua konsentrasi ( 70 g : 30 g )); X4 (ekstrak gadung
dengan lidah mertua konsentrasi ( 60 g : 40 g )); X5 (ekstrak gadung dengan lidah
mertua ( 50 g : 50 g )); X6 (ekstrak gadung dengan lidah mertua konsentrasi ( 40 g :
60 g )); X7 (ekstrak gadung dengan lidah mertua konsentrasi ( 30 g : 70 g )); X8
(ekstrak gadung dengan lidah mertua konsentrasi ( 20 g : 80 g )); X9 (ekstrak
gadung dengan lidah mertua konsentrasi ( 10 g : 90 g )); X10 (ekstrak lidah mertua
dengan konsentrasi 100 g)) dan X11 (ekstrak gadung dengan konsentrasi 100 g).
Setiap perlakuan diulang masing-masing tiga kali. Parameter pengamatan yang
ii
diamati meliputi intensitas serangan hama, populasi walang sangit, populasi
musuh alami dan berat kering tanaman padi pada setiap perlakuan. Analisis
statistik yang digunakan adalah Sidik Ragam (ANOVA), dan apabila hasil yang
diperoleh berbeda nyata diuji menggunakan Uji Duncan dengan taraf 5%.
Hasil penelitian menunjukkan bahwa ekstrak gadung dengan lidah mertua
konsentrasi 40 g gadung : 60 g lidah mertua mampu menurunkan jumlah populasi
walang sangit pada tanaman padi sebesar 100 persen. Intensitas serangan hama
dapat ditekan menggunakan kombinasi ekstrak gadung dan lidah mertua
konsentrasi 50 g gadung : 50 g lidah mertua sebesar 0,92 persen. Pengaplikasian
insektisida nabati lidah mertua dan umbi gadung tidak berpengaruh negatif
terhadap jumlah populasi musuh alami. Hasil perhitungan berat kering tanaman
padi terbanyak terlihat pada konsentrasi 100 g gadung yang menghasilkan gabah
sebanyak 1,84 kg sedangkan yang paling sedikit pada konsentrasi 70 g gadung : 30
g lidah mertua sebanyak 0,68 kg
Le relazioni esterne delle organizzazioni internazionali
No full textLa rilevanza del fenomeno dell’organizzazione internazionale nell’odierna comunità degli Stati è un dato oggettivo ampiamente riconosciuto, testimoniato dell’ampia diffusione di forme istituzionalizzate di cooperazione internazionale che si riscontra sia in ambito universale che regionale. Diretta conseguenza di tale proliferazione è stata la diversificazione dei modelli giuridici e delle tipologie organizzative che ha incrementato, rispetto ad un passato abbastanza prossimo, la complessità dell’analisi e della ricostruzione giuridica del fenomeno nel suo insieme. Ciò ha imposto il riferimento ad una pluralità di tipologie associative anche atipiche e il tentativo di ricondurre ad unità tale multiforme realtà. Da qui un approccio che, per quanto possibile, superasse, ricomprendendolo, il modello classico di organizzazione internazionale elaborato dalla dottrina. In tale contesto, articolato e plurale, la chiave di lettura condivisa rimane il carattere strumentale dell’organizzazione, alla quale gli Stati affidano funzioni che non possono, per la loro natura, essere esercitate dal singolo Stato ovvero che, meglio o più adeguatamente, possono essere svolte in comune. Sì che la dialettica fra la sovranità statuale e le funzioni attribuite all’organizzazione, costituisce nel presente volume lo strumento interpretativo privilegiato. Il volume è frutto del lavoro ad un tempo individuale e collettivo dei diversi autori che hanno condiviso l’impostazione complessiva, svolgendola ciascuno secondo la propria sensibilità personale
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