625 research outputs found
Macrolides: properties, synthesis and applications/ Biljana Arsic, Predrag Novak, Jill Barber, Maria Grazia Rimoli, Goran Kragol, Federica Sodano.
No full textIncludes bibliographical references and index."Macrolides, a class of natural macrocyclic products, are among the most clinically important antibiotics. The authors introduce the different classes of macrolides and their derivatives, principles of their biological activity, as well as synthesis methods of macrolide antibiotics"--Provided by publisher.Arsic, Biljana / Barber, Jill / Novak, Predrag -- Kragol, Goran -- Novak, Predrag -- Sodano, Federica / Rimoli, Maria Grazia -- Frontmatter -- Preface -- Contents -- 1. The macrolide antibiotics and their semi-synthetic derivatives / 2. The semisynthetic routes towards better macrolide antibiotics / 3. Interactions of macrolides with their biological targets / 4. Hybrids of macrolides and nucleobases or nucleosides: synthetic strategies and biological results / Index1 online resourc
Animals and philosophers: Preface to my critics
No full textThe author is here seeking to expose his book Philosophical Animal zoographical persuasion to philosophy, to his own remorseless analysis - and that way defend the book from potential criticism by the others. On the other hand, the author believes that this will open up the space for discussion about the book and themes that book provokes. This discussion is not going to be mere neatly registered response and/or appropriate praise but a contribution inspired by the book, resonating back to it
"Author Meets Critics: Predrag Cicovacki, Author of Gandhi's Footprints, Meets Critics Sanjay Lal and Carlo Filice"
No full textTwo critics respond to Predrag Cicovacki’s book, Gandi’s Footprints. Cicovacki opens the discussion by presenting his motivations for exploring a paradox, that Gandhi’s work is widely revered but not widely emulated. Cicovacki explores a resolution to the paradox by suggesting how Gandhi’s promising visions may be followed without being imitated, especially Gandhi’s insight that we must seek spiritual grounding for life in a materialistic world. Critic Sanjay Lal affirms Cicovacki’s insight but suggests that precisely because Gandhi’s aspirations for spiritual life were profoundly transformative we should take care not to dilute them into our conventional wisdoms. Critic Carlo Filice asks how Gandhi’s commitment to unified reality could be more clearly articulated once a distinction is drawn between spirit and matter, also how Gandhi’s nonviolence could manage to embrace important exceptions. In reply to critics, Cicovacki proposes an approach to Gandhi informed by the insights of Tagore
(In)Visible Hand(s)
No full textIn this paper, the author discusses the regulatory role of the state and legal norms, in market economy, especially in so-called transition countries. Legal policy, and other questions of the state and free market economy are here closely connected, because the state must ensure with legal norms that economic processes are not interrupted: only the state can establish the legal basis for a market economy. The free market’s invisible hand is acting in questions such as: what is to be produced, how much is to be produced, for whom it is to be produced, how it is to be produced. During the transition period but also in the establishnig EU, the role of legal norms is much more important then it (is) would be expected: problems of transition are more connected with ethics and psychology, then with legislation.Law and economics, legal norms, (de)regulation, State
Bioactive metabolites isolated from Hericium erinaceus (Bull.) Pers.
No full textHericium erinaceus is considered one of the most promising medicinal fungi for the treatment
of neurodegenerative diseases, containing a wide variety of bioactive compounds, including
hericenones, erinacines, and many other related molecules, which exhibit significant
neurotrophic and neuroprotective properties. Previous studies demonstrated that erinacine
enriched mycelium of H. erinaceus can delay neuronal cell death in animal models of
neurodegenerative conditions such as Alzheimer’s disease and ischemic stroke. [1] Our research
focus on the isolation of a diverse range of bioactive compounds from employing conventional
chromatographic techniques, followed by their structural characterization predominantly
through nuclear magnetic resonance (NMR) spectroscopy. Hericene A was isolated from the
ethyl acetate extract of the H. erinaceus fruiting bodies by performing gravitational
chromatography, followed by additional purification on semi-dry flash chromatography.
Furthermore, erinacines A and C were isolated from the ethyl acetate extract of the mycelium.
The extract was initially processed through semi-dry flash chromatography, followed by
subsequent purification utilizing preparative high-performance liquid chromatography (HPLC).
The structures of isolated compounds were determined using 1D (¹H NMR and 13C) and 2D
(COSY, JRES, HMBC, HSQC and NOESY) NMR experiments. These purification methodologies
demonstrated high efficiency and cost-effectiveness, resulting in the isolation of pure natural
compounds appropriate for subsequent pharmacological investigations. Future investigations
will prioritize the optimization of isolation protocols for various metabolites derived from both
the mycelium and fruiting bodies of H. erinaceus, alongside comprehensive characterization and
systematic evaluation of their biological activities, with the aim of elucidating potential
therapeutic applications in the treatment of neurodegenerative disorders, particularly
Alzheimer's disease.Bregović N, Namjesnik D, Novak P, Parlov Vuković J, editors. Book of Abstracts: Adriatic NMR Conference; 2025 Sep 18-20; Vodice, Croatia. Zagreb: Croatian Chemical Society; 2025. p. 52
Directionality of Intrinsic Deuterium Isotope Effects in 13C NMR Spectra of Molecules Containing One or Two Phenyl Groups
No full textIntrinsic deuterium-induced isotope effects have been measured and analyzed for compounds having one or two phenyl groups specifically labelled at different positions in a molecule. Some typical examples of directional and orientational dependence of the effects have been given. Different magnitudes of isotope effects that are transmitted in opposite directions have been observed. Thus, in p-2H-cis-stilbene, the effect over six bonds at C-α of 8.7 ppb is found, while the corresponding effect in α-2H-cis-stilbene at C-4 is only 1.4 ppb. Similarly, in o'-2H-trans-N-benzylideneaniline, the effect over six bonds at C-2,6 is 1.7 ppb, whereas that in o-2H-trans-N-benzylideneaniline at C-2',6' is equal to zero. Similar behaviour was observed in other molecules and at other positions as well. Additional factors contributing to the magnitude and sign of isotope effects, such as π-electron delocalization, conformation, steric hindrance and lone pair electrons are also discussed
Adriatic NMR Conference 2020
No full textAdriatic NMR Conference 2020
September 22–24, 2020, Peroj (Istria), Croatia
https://adriatic-nmr-conference.chem.pmf.hr/
This work is licensed under a Creative Commons Attribution 4.0 International License
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