7,560 research outputs found
Cult: A Composite Novel
No full textCult (redacted)
The first component of the thesis is a composite novel called Cult which falls into two parts with seven narratives in each. Part 1 tracks the protagonist, Ellen, from her first involvement with the cult through to her eventually leaving it. Although fiction, the first half of the book answers the kinds of questions the author is asked when people discover that she was once a sannyasin (a follower of the guru Bhagwan Shree Rajneesh). While the experiences of meditation, group therapy and communal living are all faithfully rendered within the stories, the need for strong characters, narrative drive and a lightness of touch takes precedence.
Part 2 picks up Ellen’s story some twenty or so years later and explores what becomes of her in middle age. It also looks at other groups in society, such as academia, the law and the internet dating community which each have their own jargon, hierarchies, rituals and rules but are not considered to be cults.
The book examines the question raised in the Epigraph, ‘how do we be together when we feel so alone’ with a focus on relationships other than the familial and the romantic.
Collisions, Chasms and Connections: a Performative Exploration of the Composite Novel Form
The second part of the thesis is both a critical and creative response to three contemporary American books: Olive Kitteridge by Elizabeth Strout; A Visit from the Goon Squad by Jennifer Egan; and Legend of a Suicide by David Vann. The critical element comprises a close reading of the three books; a chronological reconstruction of their overarching storylines; and a consideration of what their authors have said about writing the books. It concludes that, in the composite novel, the simultaneous presentation of multiple views and storylines operate much like a 3D image to give the impression of depth to the characters and situations rendered. The creative element of the essay is a playful and personal response to the texts
Immaculate catalogues, indexes and monsters too…: David E. Bennett reports on the three-day residential CILIP Cataloguing and Indexing Group Annual Conference, University of East Anglia, Norwich, UK, 13-15 September 2006.
No full textDynamics and folding of single two-stranded coiled-coil peptides studied by fluorescent energy transfer confocal microscopy
No full textWe report single-molecule measurements on the folding and unfolding conformational equilibrium distributions and dynamics of a disulfide crosslinked version of the two-stranded coiled coil from GCN4. The peptide has a fluorescent donor and acceptor at the N termini of its two chains and a Cys disulfide near its C terminus. Thus, folding brings the two N termini of the two chains close together, resulting in an enhancement of fluorescent resonant energy transfer. End-to-end distance distributions have thus been characterized under conditions where the peptide is nearly fully folded (0 M urea), unfolded (7.4 M urea), and in dynamic exchange between folded and unfolded states (3.0 M urea). The distributions have been compared for the peptide freely diffusing in solution and deposited onto aminopropyl silanized glass. As the urea concentration is increased, the mean end-to-end distance shifts to longer distances both in free solution and on the modified surface. The widths of these distributions indicate that the molecules are undergoing millisecond conformational fluctuations. Under all three conditions, these fluctuations gave nonexponential correlations on 1- to 100-ms time scale. A component of the correlation decay that was sensitive to the concentration of urea corresponded to that measured by bulk relaxation kinetics. Thetrajectories provided effective intramolecular diffusion coefficients as a function of the end-to-end distances for the folded and unfolded states. Single-molecule folding studies provide information concerning the distributions of conformational states in the folded, unfolded, and dynamically interconverting states.Author manuscript. Published in final edited form as: Proc Natl Acad Sci U S A. 2000 November 21; 97(24): 13021-13026.The final published version of this article is located at: http://www.pnas.org/cgi/reprint/97/24/13021NIH GM54616; to William F. DeGradoNIH GM12592; to Robin M. HochstrasserNIH GM48130; to William F. Degrado and Robin M. HochstrasserThis work was supported by GM54616 (to W.F.D.), GM12592 (to R.M.H.) and GM48130 (to W.F.D. and R.M.H.) with instrumentation developed under RR01348. D.S.T. was supported by National Institutes of Health Grant NRSA F32-GM18589.Also available in PubMed Central. PMCID:PMC2717
An Impact Study of the Economic Partnership Agreements (EPAs) in the Six ACP Regions
No full textThis article intends to present a very detailed analysis of the trade-related aspects of Economic Partnership Agreements (EPAs) negotiations. We use a dynamic partial equilibrium model – focusing on the demand side – at the HS6 level (covering 5,113 HS6 products). Two alternative lists of sensitive products are constructed, one giving priority to the agricultural sectors, the other focusing on tariff revenue preservation. In order to be WTO compatible, EPAs must translate into 90 percent of bilateral trade fully liberalised. We use this criterion to simulate EPAs for each negotiating regional block. ACP exports to the EU are forecast to be 10 percent higher with the EPAs than under the GSP/EBA option. On average ACP countries are forecast to lose 70 percent of tariff revenues on EU imports in the long run. Yet imports from other regions of the world will continue to provide tariff revenues. Thus when tariff revenue losses are computed on total ACP imports, losses are limited to 26 percent on average in the long run and even 19 percent when the product lists are optimised. The final impact on the economy depends on the importance of tariffs in government revenue and on potential compensatory effects. However this long term and less visible effect will mainly depend on the capacity of each ACP country to reorganise its fiscal base.Preferential Trade Agreements, Africa, EPAs, Partial Equilibrium Simulations, International Relations/Trade,
Corrigendum: Pneumococcal vaccine impacts on the population genomics of non-typeable haemophilus influenzae: (Microbial Genomics 2021; 9, 10.1099/mgen.0.000209)
No full textThere was a change in the author names in the published article. The new list should read: David W. Cleary1,2, Vanessa T. Devine3, Denise E. Morris1, Karen L. Osman1, Rebecca A. Gladstone4, Stephen D. Bentley4, Saul N. Faust1,5, Stuart C. Clarke1,2,6 1Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK. 2NIHR Southampton Biomedical Research Centre, University Hospital Southampton Foundation NHS Trust, Southampton, UK. 3Northern Ireland Centre for Stratified Medicine and Clinical Translational Research Innovation Centre, Londonderry, UK. 4Pathogen Genomics, Wellcome Trust Sanger Institute, UK. 5NIHR Southampton Clinical Research Facility, University Hospital Southampton Foundation NHS Trust, Southampton, UK. 6Global Health Research Institute, University of Southampton, Southampton, UK.</p
Serializing Evil: David Peace and the Formulae of Crime Fiction
No full textTraditionally, in crime fiction, a series is grounded in the permanence of the protagonist that keeps being the same all through the different stories that are told by the author, possibly evolving over time, but always keeping identifiable and providing the series with its unifying element. It is not so with David Peace. Unversally considered as one of the most brilliant and unusual novelist in contemporary crime fiction, Peace is the author of two series: the so called Red Riding Quartet (set in Yorkshire, UK, and also adapted as a television series) and the Tokyo trilogy (not completed yet, with its third novel still on the way). In both series, Peace chooses to construct a web of interlaced stories where the protagonists are all different while the setting stays the same. In the Red Riding Quartet, this strategy seems even more sophisticated, in that the protagonist of each book ends by either dying or going crazy, to be replaced, in the next novel, by one of the secondary characters that suddenly switches to a primary role.
By his own admission in several interviews, Peace is interested in portraying the many sides of evil. Consequently, this strategic and stylistic choice seems to suggest a very specific stance, an ethic of persuasion that any human being, in given circumstances, may become a criminal.
Just like in Dickens, the story is always well documented and moulded by a sharp awareness of the historic conditions marking the context, be it a small city in Yorkshire, in Thatcher’s years, or the recently defeated Tokyo. The settings are normally overdetermined, and so are also the choices of the characters and their behaviours, that appear tightly, often compulsively oriented by strongly restraining circumstances
Microbial enrichment culture responsible for the complete oxidative biodegradation of 3‑Amino-1,2,4-triazol-5-one (ATO), the reduced daughter product of the insensitive munitions compound 3‑Nitro-1,2,4-triazol-5-one (NTO)
No full text3-Nitro-1,2,4-triazol-5-one (NTO) is one of the main ingredients of many insensitive munitions, which are being used as replacements for conventional explosives. As its use becomes widespread, more research is needed to assess its environmental fate. Previous studies have shown that NTO is biologically reduced to 3-amino-1,2,4-triazol-5-one (ATO). However, the final degradation products of ATO are still unknown. We have studied the aerobic degradation of ATO by enrichment cultures derived from the soil. After multiple transfers, ATO degradation was monitored in closed bottles through measurements of inorganic carbon and nitrogen species. The results indicate that the members of the enrichment culture utilize ATO as the sole source of carbon and nitrogen. As ATO was mineralized to CO₂, N₂, and NH₄⁺, microbial growth was observed in the culture. Co-substrates addition did not increase the ATO degradation rate. Quantitative polymerase chain reaction analysis revealed that the organisms that enriched using ATO as carbon and nitrogen source were Terrimonas spp., Ramlibacter-related spp., Mesorhizobium spp., Hydrogenophaga spp., Ralstonia spp., Pseudomonas spp., Ectothiorhodospiraceae, and Sphingopyxis. This is the first study to report the complete mineralization of ATO by soil microorganisms, expanding our understanding of natural attenuation and bioremediation of the explosive NTO.Journal ArticleFinal article publishe
Post-war British working-class fiction with special reference to the novels of John Braine, Alan Sillitoe, Stan Barstow, David Storey and Barry Hines
No full textThis study is about British working-class fiction in the post-war period.
It covers various authors such as Robert Tressell, George Orwell, Walter Greenwood, Lewis Grassic Gibbon and DH Lawrence from the early twentieth century; writers traditionally classified as 'Angry Young Men' like John Osborne, Arnold Wesker, Shelagh Delaney, John Wain and
Kingsley Amis; and working-class novelists like John Braine, Stan Barstow, David Storey, Alan Sillitoe and Barry Hines from the 1950s and 1960s.
Some of the main issues dealt with in the course of this study are language, form, community, self/identity/autobiography, sexuality and relationship with bourgeois art. The major argument centres on two questions: representation of working-class life, and the
relationship between working-class literary tradition and dominant ideologies.
We will be arguing that while working-class fiction succeeded in challenging and rupturing bourgeois literary tradition, on the level of language and linguistic medium of expression for example, it utterly failed to break away from dominant, bourgeois modes of literary production in relation to form, for instance.
Our argument is situated within Marxist approaches to literature, a political and aesthetic position from which we attempt an analysis and an evaluation of this working-class literary tradition. These critical approaches provide us also with the theoretical tool to define the political perspective of this tradition, and to judge whether it was confined to a descriptive mode of representation or
located in a radical, political outlook
Author, Author, o la celebración del ser y del autor (Parte II)
No full textIn the last years David Lodge has been particularly concerned with the way in which both science and the humanities are challenging the traditional idea of the self as unique and
autonomous: “If the self is a fiction, it may perhaps be the supreme fiction, the greatest
achievement of human consciousness, the one that makes us human.” For Lodge the novel
is the genre that best reflects the subjectivity of human experience, thus offering us the
richest and most comprehensive record of human consciousness. His last novel, Author,
Author, like the previous one, Thinks... is a clear apology of the autonomous, individual
self, not only because its main character is a writer, Henry James, who always defended that
the subject of the novel was the whole of human consciousness, but because it allows us to
have access to his inner thoughts and feelings, precisely those that cannot be described by
science.En los últimos años David Lodge se ha interesado particularmente por el modo en que
tanto la ciencia como las humanidades han cuestionado el concepto tradicional del ser
humano como individuo único y autónomo: “If the self is a fiction, it may perhaps be the
supreme fiction, the greatest achievement of human consciousness, the one that makes us
human.” Para Lodge la novela es el género que mejor refleja la subjetividad de la experiencia
humana, ofreciéndonos la más rica y extensa descripción de la consciencia humana. Su
última novela, Author, Author, como la anterior, Thinks... es una clara apología del ser indi-
vidual y autónomo, no sólo porque su principal personaje sea un autor, Henry James, que
siempre defendió que el principal tema de la novela debía ser la totalidad de la consciencia
humana, sino también porque nos permite tener acceso a sus pensamientos y sentimientos
más íntimos, precisamente aquellos que no pueden ser descritos por la ciencia
N omega-nitro-L-arginine methyl ester inhibits inflammatory liver injury induced by interleukin-2
No full textAdministration of interleukin-2 (IL-2) for treatment of metastatic disease often results in inflammatory liver injury. Previous studies have implicated increased leukocyte and platelet adhesion and enhanced nitric oxide production as causative factors in the development of IL-2-induced hepatic injury. This study investigated the capacity of N omega-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthesis inhibitor, to limit IL-2-induced hepatic edema and hepatocellular damage in mice. Using hepatic intravital microscopy, we also examined the effects of L-NAME on IL-2-induced increases in leukocyte and platelet adhesion. Administration of IL-2 increased leukocyte and platelet adhesion in post-sinusoidal venules and decreased hepatic perfusion. Cotreatment with L-NAME had no effect on leukocyte adhesion but increased platelet-endothelial adhesion and microvascular thrombosis. Chronic IL-2 treatment induced hepatic edema and hepatocellular injury. However, coadministration of L-NAME attenuated IL-2-induced edema and completely inhibited hepatocellular damage. These findings suggest that nitric oxide may play a central role in IL-2-induced inflammatory liver injury.LR: 20061115; PUBM: Print; JID: 8405628; 0 (Enzyme Inhibitors); 0 (Interleukin-2); 10102-43-9 (Nitric Oxide); 50903-99-6 (NG-Nitroarginine Methyl Ester); EC 1.14.13.39 (Nitric Oxide Synthase); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase); ppublishSource type: Electronic(1
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