86,788 research outputs found
Madame Colyn de Nole
No full textPostal que reproduce una pintura del año 1631-1632 de Antoon van Dyck. Representa a la esposa de Colyn de Nole junto a su hija en una escena de interior, ambas visten a la moda de la época. https://www.sammlung.pinakothek.de/en/bookmark/artwork/wq4jAO6GWoEn la postal aparece el siguiente texto: MünchenEn Sammlung Pinakothek aparece titulada: Bildnis der Anna van Thielen, Gattin des Malers Theodoor Rombouts, mit ihrer Tochter Anna Mari
Nolen, Mrs. F. E. (child)
No full textPhotograph from the C.R. Savage Portrait Studio. Name associated with the photograph: Mrs. F. E. Nole
Nolen, Mrs. F. E. (girl)
No full textPhotograph from the C.R. Savage Portrait Studio. Name associated with the photograph: Mrs. F. E. Nole
Biogeographic variability in wildfire severity and post-fire vegetation recovery across the European forests via remote sensing-derived spectral metrics
No full textWildfires have large-scale and profound effects on forest ecosystems, and they force burned forest areas toward a wide range of post-fire successional trajectories from simple reduction of ecosystem functions to transitions to other stable non-forest states. Fire disturbances represent a key driver of changes in forest structure and composition due to post-fire succession processes, thus contributing to modify ecosystem resilience to subsequent disturbances. Here, we aimed to provide useful insights into wildfire severity and post-fire recovery processes at the European continental scale, contributing to improved description and interpretation of large-scale wildfire spatial patterns and their effects on forest ecosystems in the context of climate change. We analyzed fire severity and short-term post-fire vegetation recovery patterns across the European forests between 2004 and 2015 using Corine Land Cover Forest classes and bioregions, based on MODIS-derived spectral metrics of the relativized burn ratio (RBR), normalized difference vegetation index (NDVI) and relative recovery indicator (RRI). The RBR-based fire severity showed geographic differences and interannual variability in the Boreal bioregion compared to that in other biogeographic regions. The NBR-based RRI showed a slower post-fire vegetation recovery rate with respect to the NDVI, highlighting the differential sensitivities of the analyzed remote sensing-spectral metrics. Moreover, the RRI showed a significant decreasing trend during the observation period, suggesting a growing lag in post-fire vegetation recovery across European forests
VGI and crisis mapping in an emergency situation. Comparison of four case studies: Haiti, Kibera, Kathmandu, Centre Italy
No full textOver the last decade new voluntary mapping patterns are commonly known as VGI - Volunteered Geographic Information - that is, geo-localized information created voluntarily and consciously by web users. These are supported by platforms such as OpenStreetMap that have been shown in many emergency cases and not, a valid source of data, such detailed to be used tor rescue operations. Another completely open source platform that has revolutionized the world of geographic information and how to make reports Is Ushaidi that through interactive maps represents testimonies, reports, diaries, and citizen reports
Early estimation of ground displacements and building damage after seismic events using SAR and LiDAR data: The case of the Amatrice earthquake in central Italy, on 24th August 2016
No full textThe increasing accessibility of Synthetic Aperture Radar (SAR) and Light Detection and Ranging (LiDAR) data, grants the opportunity to experiment new methods to support disaster risk management. However, while SAR analyses are becoming extremely popular, thanks, in particular, to the availability of open source satellite images such as those from the Copernicus project, LiDAR analyses are still less common because of the scarce availability of this type of data over significant time frequencies. In this paper we propose an innovative procedure based on the use of SAR and LiDAR data to rapidly assess seismic damage in the early post-emergency phases. The methodology was applied to the case study of the town of Amatrice (Central Italy), which was hit by a strong earthquake swarm that started in August 2016. Specifically, SAR data is used for a large-scale analysis of terrain displacements following the seismic event, while LiDAR reliefs are used to carry out a change detection and to identify the level of damage at a building-scale in the urban settlement of Amatrice. Results will show how the proposed approach can be extremely effective both in the non-emergency phases to monitor seismic-affected areas and support emergency planning, as well as during the immediate post-earthquake phases to assess the damage it has caused and to support first aid dispositions
Chemotherapy of advanced malignant-melanoma : review
No full textThe role of medical treatment in advanced or metastatic malignant melanoma is still controversial, and there is no standard systemic therapy. Dacarbazine has been the most widely used single drug, despite its response rate range of 10-25%. A number of new drugs, polychemo-therapeutic regimens and combined modalities have been explored. Fotemustine, a new chloronitrosourea, is one of the most promising, and is active against disseminated malignant melanoma, in particular against brain metastases. Cisplatin has modest activity as single agent but positive results have been reported when it is combined with dacarbazine. Modulation of the activity of cisplatin and dacarbazine by tamoxifen has recently been postulated. The results of the few clinical trials in malignant melanoma are interesting but controversial. Interleukin-2 and interferon are active in this disease, but no more so than individual chemotherapeutic drugs. However, despite their high cost, combinations of immuno- and chemotherapeutic agents have been extensively investigated in order to evaluate possible synergisms. The above-mentioned efforts have produced contradictory results that are partly related to the difficulty in establishing whether a positive or negative treatment outcome is due to the chosen therapy or patient selection. For these reasons, patients with advanced malignant melanoma should be treated according to research protocols in specialized centers until an effective approach is developed
Reversal of resistance to doxifluridine and fluorouracil in metastatic colorectal cancer: the role of high-dose folinic acid
No full textThe benefits from medical treatment in colorectal cancer are limited. Fluorouracil remains the only recognized drug, and how to treat unresponsive patients is still debated. To evaluate the role of folinic acid (FA) in circumvence resistance in colorectal cancer, 28 patients pretreated with fluoropyrimidine were candidated to receive one of the following schedules: fluorouracil (600 mg/ml associated with FA (500 mg/ml weekly for 6 weeks (Regimen A: 21 cases), or fluorouracil (370 mg/ml plus FA (200 mg/ml daily for 5 days every 4 weeks (Regimen B: 7 cases). Fourteen patients were pretreated with doxifluridine, a new fluoropyrimidine derivative with a peculiar mechanism of action, and the remaining 14 patients with fluorouracil. All but 2 patients were unresponsive to first-line treatments. When the treatment began, the median age of the patients was 60 years (range, 30-68). The performance status (ECOG) was 0/1 in 25 of them, and the primary tumor was in the colon and rectum in 19 and 9 patients, respectively. Sites of disease were liver (64%), lung (35%), local recurrence (10%) and peritoneum (10%). A median of 3 cycles (range, 1-7) was delivered, and no objective response was observed in the group of patients pretreated with doxifluridine or in the group pretreated with fluorouracil. In 5 cases a significant decrease in baseline CEA values was observed. Therapy was well tolerated, and no grade 4 toxicity was encountered. Severe toxicity was limited and included diarrhea (7 patients), stomatitis (1 patient) and nausea/vomiting (1 patient). High-dose FA has no role in reversing resistance to fluoropyrimidine, and other mechanisms of refractoriness are surely involved. FA should be associated with fluoropyrimidine as first-line therapy together with other biochemical modulators. Further rescue therapies need to be developed
Mitoxantrone in patients affected by hepatocellular carcinoma with unfavorable prognostic factors
No full textPatients affected by hepatocellular carcinoma (HCC) with unfaborable prognostic factors have limited therapeutic options due to moderate responsiveness to chemotherapeutic agents and lack of compliance with such treatments. In this study the feasibility and efficacy were evaluated of a treatment with mitoxantrone (dihydroxyanthracenedione, DHAD), 12 mg/m2i.v. on day 1 every 3 weeks. We included 18 patients with poor-risk HCC ineligible for our other trials in relation to their performance status [8], pretreatments [6], age over 70 years [5], severe concomitant illness [6], and altered blood count [platelets < 100,000/mm3) [8]. Of 17 evaluable cases, there were 4 partial remissions (23%) (95% confidence interval, 10-47%), 6 no changes, and 7 progressions. There were no drug-related deaths, and side effects were moderate and documented only in a few cases. Median survival of evaluable patients was 5 months (range, 1-15). The results were comparable with those obtained with adriamycin but without important toxicity. We conclude that DHAD seems to be safe and moderately active in poor-risk HCC
Synergistic activity of oxaliplatin and 5-fluorouracil in patients with metastatic colorectal cancer with progressive disease while on or after 5-fluorouracil
No full textFrom February 1995 through October 1996, 25 patients with metastatic colorectal cancer showing a clinical resistance to 5-fluorouracil (5-FU) entered this study. Thirteen received oxaliplatin alone and 12 received it in combination with 5-FU. Oxaliplatin was administered at 130 mg/m(2) over a 2-hour infusion every 3 weeks, alone or added either to 5-FU as a continuous infusion at 200 mg/m(2) to 300 mg/m(2) (six patients) or to a 5-FU bolus, 375 mg/m(2), plus leucovorin, 100 mg/m(2) daily for 5 days every 3 weeks (6 patients).
Eighty-six of 98 administered cycles were evaluable for toxicity (47 for oxaliplatin plus 5-FU and 39 for oxaliplatin alone). Hematologic toxicity was mild, occurring as grade 2 leukopenia in 23% of the cycles of 5-FU and oxaliplatin and in 5% of the cycles of oxaliplatin alone. The most common toxicity was neurologic (grade 1 to 2 in 60%-6% of the cycles of the combination, respectively, and 68%-10% of oxaliplatin given alone) as hand-foot paresthesia or hypersensitivity to cold. No grade 4 toxicity was reported and only three patients in the 5-FU group developed grade 3 diarrhea. Grade 2 nausea and vomiting occurred in 33% of the cycles when both drugs were given and in 15% when oxaliplatin was administered alone.
The combination of oxaliplatin and 5-FU induced four partial remissions (33%; 95% confidence interval, 6%-60%), whereas eight patients of the whole group had stable disease. No response occurred when oxaliplatin was administered as a single agent. The results of this study confirm the antitumor activity of oxaliplatin when added to 5-FU in patients who have metastatic colorectal cancer previously refractory to 5-FU. The possible therapeutic synergy with 5-FU was not accompanied by increased toxicity
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