3,994 research outputs found
Applications of Hodgkin-Huxley Equations to Excitable Tissue
No full text Denis Noble, “Applications of Hodgkin-Huxley Equations to Excitable Tissue,” p. 4, eq. 6a, should read: See PDF for Equation </jats:p
Contrasting activity profile of two distributed cortical networks as a function of attentional demands
No full textThe original publication is available at http://www.jneurosci.orgThis work was supported by R01 grant MH-073610 from the National Institutes of Health to Denis Paré
Extracellular Vesicles as Targeted Communicators in Complementary Medical Treatments
No full textThe supposed meridians of traditional oriental medicine have been a cause of conflict between traditional and modern medical science. A possible resolution has been proposed: That extracellular vesicles, including exosomes, may be the transmitters of traditional therapies such as massage and acupuncture. This article develops that idea by proposing that the pathways between surface and deep structures may be laid down during the embryonic migration of cells from one region of the developing body to distant regions. This hypothesis depends on the proven targeting of vesicular communication via cell surface binding molecules and their complementary binding sites on target cells. The hypothesis is therefore experimentally testable. The article also draws attention to a strong analogy with Charles Darwin’s theory of pangenesis for particulate communication between the soma and germline
Rebuttal: "The funny current in the context of the coupled clock pacemaker cell system".
No full textIs Tolerance Political? An Interview with Denis Lacorne
No full textcontribution à un site webDenis Lacorne is the author of "The Limits of Tolerance. Enlightenment Values and Religious Fanaticism" (Columbia University Press, 2019), the English translation of "Les limites de la tolérance" (Gallimard, awarded the Prix Montyon by the Académie Française). In his book, which is intellectually very inspiring because of the many questions it addresses and raises, Denis Lacorne traces the emergence of the notion of tolerance from its early thinkers to the Age of Enlightenment and finally questions the notion and its various understandings through more recent events in France and the United States. What is tolerance? Is tolerance political? Interview by Miriam Périer, CER
Timing of impulses from the central amygdala and bed nucleus of the stria terminalis to the brainstem
No full textThe amygdala and bed nucleus of the stria terminalis (BNST) are thought to subserve distinct functions with the former mediating rapid fear responses to discrete sensory cues and the latter longer “anxiety-like” states in response to diffuse environmental contingencies. Yet, these structures are reciprocally connected and their projection sites overlap extensively. To shed light on the significance of BNST-amygdala connections, we compared the antidromic response latencies of BNST and central amygdala (CE) neurons to brainstem stimulation. Whereas the frequency distribution of latencies was unimodal in BNST neurons (~10 ms mode), that of CE neurons was bimodal (~10 and ~30 ms modes). However, after stria terminalis (ST) lesions, only short-latency antidromic responses were observed, suggesting that CE axons with long conduction times course through the ST. Compared to the direct route, the ST greatly lengthens the path of CE axons to the brainstem, an apparently disadvantageous arrangement. Since BNST and CE share major excitatory basolateral amygdala (BL) inputs, lengthening the path of CE axons might allow synchronization of BNST and CE impulses to brainstem when activated by BL. To test this, we applied electrical BL stimuli and compared orthodromic response latencies in CE and BNST neurons. The latency difference between CE and BNST neurons to BL stimuli approximated that seen between the antidromic responses of BNST cells and CE neurons with long-conduction times. These results point to a hitherto unsuspected level of temporal coordination between the inputs and outputs of CE and BNST neurons, supporting the idea of shared functions.The original publication is available at: http://jn.physiology.org/cgi/content/full/100/6/342
Influence of Na/Ca exchange stoichiometry on model cardiac action potentials.
No full textCardiac action potential simulations were done with the stoichiometry of the Na/Ca exchanger set a 4: 1. Using the Hilgemann-Noble (1987) model, this stoichiometry reduces the resting potential unless regulation by intracellular calcium is incorporated. The K(d) required for such regulation is consistent with current experimental estimates of this parameter
Successes and failures in modeling heart cell electrophysiology.
No full textMathematical models of the electrical activity of the heart using equations for protein ion channels and other transporters began with the Noble 1962 model. These models then developed over a period of about 50 years. Cell types in all regions have been modeled and now are available for download from the CellML website (www.cellml.org). Simulation is a necessary tool of analysis in attempting to understand biological complexity. We often learn as much from the failures as from the successes of mathematical models. It is the iterative interaction between experiment and simulation that is important
Rehab Depot de la Plaine Saint-Denis
No full textRedesign for workshop Atelier Revision Intermediaire at the Depot de la Plaine Saint-Denis with a rehabilitation center as new functionRMITArchitecture and The Built Environmen
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