1,721,304 research outputs found
PET is better than perfusion SPECT for early diagnosis of Alzheimer's disease -- against
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Cognitive reserve and clinical expression of Alzheimer's disease: evidence and implications for brain PET imaging
No full textCognitive reserve (CR) refers to the hypothesized capacity of an adult brain to cope with brain damage in order to minimize symptomatology. The present review is focused on the contribution of brain PET in the understanding of the influence of CR on the disassociation between cognition and degree of Alzheimer's disease (AD) pathology. Theories for the explanation CR-related mechanism as well as PET imaging evidence for the existence of CR are described. Moreover functional imaging studies investigating specific networks for CR both in healthy subjects and AD patients are discussed. Finally implications for amyloid PET imaging are presented
The impact of molecular imaging in the management of movement disorders: An ongoing revolution
No full textIs dopamine transporter invariably impaired at the time of diagnosis in dementia with Lewy bodies?
Full text link[Regional cerebral blood flow and anxiety: a correlative study]
No full textThe effect of anxiety (measured by the state-trait anxiety inventory) on resting regional cerebral blood flow (rCBF) (measured by the 133-Xenon inhalation method) was studied in 38 female and 37 male patients undergoing rCBF examination for the first time. Significant negative correlations were found between anxiety and rCBF. This could contribute in understanding rCBF variability in the so-called "resting condition"
Standardised normal distribution analysis on spect datasets before and donepezil in Alzheimer's disease
No full textFusion of the MR image to SPECT with possible correction for partial volume effect.
No full textABSTRACT—Low spatial resolution and the related partial volume effects limit the diagnostic potential of brain single photon emission computed tomography (SPECT) imaging. As a possible remedy for this problem we propose a technique for the fusion of SPECT and MR images, which requires for a given patient the SPECT data and the T1-weighted MR image. Basically, after the reconstruction and coregistration steps, the high-frequency part of the MR, which would be unrecoverable by the set SPECT acquisition system +
reconstruction algorithm, is extracted and added to the SPECT image. The tuning of the weight of the MR on the resulting fused image can be performed very quickly, any iterative reconstruction algorithm can be used and, in the case that the SPECT projections are not available, the proposed technique can also be applied directly to the SPECT image, provided that the performance of the scanner is known. The procedure has the potential of increasing the diagnostic value of a SPECT image. Even in the locations of SPECT-MR mismatch it does not significantly affect quantitation over regions of interest (ROIs) whose dimensions are decidedly larger than the SPECT resolution distance. On the other hand, appreciable corrections for partial volume effects are expected in the locations where the contrast in the structural MR matches the corresponding contrast in functional activity
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