71 research outputs found
Corrigendum to "European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2023 Guidelines” [Eur. Urol. 85 (2024) 17–31, (S0302283823030737), (10.1016/j.eururo.2023.08.016)]
No full textThe authors regret the oversight in the initially published version of this article, where the name of Prof. Paramananthan Mariappan, along with his affiliation to the Edinburgh Bladder Cancer Surgery (EBCS), Western General Hospital, at The University of Edinburgh, Edinburgh, United Kingdom, was inadvertently omitted from the author list. This has now been updated. The authors would like to apologise for any inconvenience caused
Manufacturing Processes for Permanent Magnets: Part II—Bonding and Emerging Methods
No full textPermanent magnets produce magnetic fields and maintain the field even in the presence of an opposing magnetic field. They are widely used in electric machines, electronics, and medical devices. Part I reviews the conventional manufacturing processes for commercial magnets, including Nd-Fe-B, Sm-Co, alnico, and ferrite in cast and sintered forms. In Part II, bonding, emerging advanced manufacturing processes, as well as magnet recycling methods are briefly reviewed for their current status, challenges, and future directions.This article is published as Cui, Jun, John Ormerod, David S. Parker, Ryan Ott, Andriy Palasyuk, Scott McCall, Mariappan Parans Paranthaman et al. "Manufacturing Processes for Permanent Magnets: Part II—Bonding and Emerging Methods." JOM 74, no. 6 (2022): 2492-2506.
DOI: 10.1007/s11837-022-05188-1.
Copyright 2022 The Author(s).
Attribution 4.0 International (CC BY 4.0).
Posted with permission.
DOE Contract Number(s): AC05-00OR22725; AC02-07CH11358; AC52- 07NA27344
Electrochemical performance of spinel-type Ni doped ZnCo2O4 mesoporous rods as an electrode for supercapacitors
No full textSynthesis, characterization, bioactivity and antibacterial studies of silver doped calcium borosilicate glass-ceramics
No full textThermal stability of anisotropic bonded magnets prepared by additive manufacturing
No full textIn this research, anisotropic NdFeB + SmFeN hybrid and NdFeB bonded magnets are additively printed in a polyphenylene sulfide (PPS) polymer binder. Printed NdFeB + SmFeN PPS bonded magnets displayed excellent magnetic properties (Br [remanence] = 6.9 kG [0.69 T], Hcj [coercivity] = 8.3 kOe [660 kA/m], and BHmax [energy product] = 9.9 MGOe [79 kJ/m3]) with superior corrosion resistance and thermal stability. The anisotropic NdFeB bonded magnet shows a high coercivity of 14.6 kOe (1162 kA/m) with a BHmax of 8.7 MGOe (69 kJ/m3). The coercivity and remanence temperature coefficients for NdFeB + SmFeN hybrid bonded magnets are −0.10%/K and −0.46%/K, and for NdFeB bonded magnets are −0.14%/K and −0.53%/K in the range of 300–400 K, indicating that the hybrid bonded magnets are thermally stable. The average flux aging loss for hybrid magnets was also determined to be very stable over 2000 h at 448 K (175°C) in air with 2.04% compared to that of NdFeB magnets with 3.62%.This article is published as Gandha, Kinjal, Mariappan Parans Paranthaman, Haobo Wang, Xubo Liu, and Ikenna C. Nlebedim. "Thermal stability of anisotropic bonded magnets prepared by additive manufacturing." Journal of the American Ceramic Society 106, no. 1 (2023): 166-171.
DOI: 10.1111/jace.18609
Copyright 2022 The Author(s).
Attribution 4.0 International (CC BY 4.0).
Posted with permission.
DOE Contract Number(s): AC02-07CH11358; AC05-00OR22725
Interaction of TNF with angiotensin II contributes to mitochondrial oxidative stress and cardiac damage in rats.
No full textRecent evidence suggests that tumor necrosis factor alpha (TNF) and angiotensin II (ANGII) induce oxidative stress contribute to cardiovascular disease progression. Here, we examined whether an interaction between TNF and ANGII contributes to altered cardiac mitochondrial biogenesis and ATP production to cause cardiac damage in rats. Rats received intraperitoneal injections of TNF (30 µg/kg), TNF + losartan (LOS, 1 mg/kg), or vehicle for 5 days. Left ventricular (LV) function was measured using echocardiography. Rats were sacrificed and LV tissues removed for gene expression, electron paramagnetic resonance and mitochondrial assays. TNF administration significantly increased expression of the NADPH oxidase subunit, gp91phox, and the angiotensin type 1 receptor (AT-1R) and decreased eNOS in the LV of rats. Rats that received TNF only had increased production rates of superoxide, peroxynitrite and total reactive oxygen species (ROS) in the cytosol and increased production rates of superoxide and hydrogen peroxide in mitochondria. Decreased activities of mitochondrial complexes I, II, and III and mitochondrial genes were observed in rats given TNF. In addition, TNF administration also resulted in a decrease in fractional shortening and an increase in Tei index, suggesting diastolic dysfunction. TNF administration with concomitant LOS treatment attenuated mitochondrial damage, restored cardiac function, and decreased expression of AT1-R and NADPH oxidase subunits. Mitochondrial biogenesis and function is severely impaired by TNF as evidenced by downregulation of mitochondrial genes and increased free radical production, and may contribute to cardiac damage. These defects are independent of the downregulation of mitochondrial gene expression, suggesting novel mechanisms for mitochondrial dysfunction in rats given TNF
Social media and its impact during the Covid-19
No full textAbstract: The primary object of this study is to survey the impact of social media on Covid-19. Therefore, a lot of research has been conducted to determine how social media is being used during the Covid-19 pandemic. Since social media have become the only means of connecting people throughout the world during the Covid-19 pandemic, this paper explores the way social media are affecting people and how this affects the Covid-19 pandemic. To that end, structured questionnaires were distributed to 256 participants. In a questionnaire, the message of respondents has been included, along with their motivational and burden factors, which are evident in their use of social media during the Covid-19 pandemic. People experience emotional problems due to the Covid-19 pandemic and are forced to look after their dependents, while some have the chance to increase their income with social media use. This research contributed to our present understanding of the public's reactions to social media during the Covid-19 pandemic. Our study found that people used social media a lot during the Covid-19 pandemic. Therefore, we can minimize the difficulties they will encounter on social media, helping them use it easily.
Keywords: Social media, Covid-19 pandemic, Emotional, Public.
Title: Social media and its impact during the Covid-19
Author: Lee Zi Shin, Sun Li Ting, Dr. Logenthini Mariappan
International Journal of Recent Research in Social Sciences and Humanities (IJRRSSH)
ISSN 2349-7831
Vol. 10, Issue 1, January 2023 - March 2023
Page No: 51-62
Paper Publications
Website: www.paperpublications.org
Published Date: 17-March-2023
DOI: https://doi.org/10.5281/zenodo.7745015
Paper Download Link (Source)
https://www.paperpublications.org/upload/book/Social%20media%20and%20its%20impact%20during-17032023-3.pdfInternational Journal of Recent Research in Social Sciences and Humanities (IJRRSSH), ISSN 2349-7831, Paper Publications, Website: www.paperpublications.or
Blueberry supplementation attenuates oxidative stress within monocytes and modulates immune cell levels in adults with metabolic syndrome: a randomized, double-blind, placebo-controlled trial
No full textBlueberry supplementation for six weeks significantly attenuated oxidative stress in the monocytes in patients with MetS.</p
TNF-induced mitochondrial damage: a link between mitochondrial complex I activity and left ventricular dysfunction
No full textMitochondrial damage is implicated in the progression of cardiac disease. Considerable evidence suggests that proinflammatory cytokines induce oxidative stress and contribute to cardiac dysfunction. This study was conducted to determine whether a TNF-induced increase in superoxide (O(2)(*)(-)) contributes to mitochondrial damage in the left ventricle (LV) by impairing respiratory complex I activity. We employed an electron paramagnetic resonance (EPR) method to measure O(2)(*)(-) and oxygen consumption in mitochondrial respiratory complexes, using an oxygen label. Adult male Sprague-Dawley rats were divided into four groups: control, TNF treatment (ip), TNF+ apocynin (APO; 200 micromol/kg bw, orally), and TNF+ Tempol (Temp; 300 micromol/kg bw, orally). TNF was injected daily for 5 days. Rats were sacrificed, LV tissue was collected, and mitochondria were isolated for EPR studies. Total LV ROS production was significantly higher in TNF animals than in controls; APO or Temp treatment ameliorated TNF-induced LV ROS production. Total mitochondrial ROS production was significantly higher in the TNF and TNF+ APO groups than in the control and TNF+ Temp groups. These findings suggest that TNF alters the cellular redox state, reduces the expression of four complex I subunits by increasing mitochondrial O(2)(*)(-) production and depleting ATP synthesis, and decreases oxygen consumption, thereby resulting in mitochondrial damage and leading to LV dysfunction
Diet‐induced Renal Changes in Zucker Rats Are Ameliorated by the Superoxide Dismutase Mimetic TEMPOL
No full textDiabetic nephropathy is the leading cause of renal failure in the United States. The obese Zucker rat (OZR; fa/fa) is a commonly used model of type 2 diabetes and metabolic syndrome (MetS), and of the nephropathy and renal oxidative stress commonly seen in these disorders. Heterozygous lean Zucker rats (LZRs; fa/+) are susceptible to high-fat diet (HFD)-induced obesity and MetS. The present study was designed to investigate whether 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPOL), a membrane-permeable radical scavenger, could alleviate the renal effects of MetS in OZR and LZR fed a HFD, which resembles the typical Western diet. OZR and LZR were fed a HFD (OZR-HFD and LZR-HFD) or regular diet (OZR-RD and LZR-RD) and allowed free access to drinking water or water containing 1 mmol/l TEMPOL for 10 weeks. When compared to OZR-RD animals, OZR-HFD animals exhibited significantly higher levels of total renal cortical reactive oxygen species (ROS) production, plasma lipids, insulin, C-reactive protein, blood urea nitrogen (BUN), creatinine (Cr), and urinary albumin excretion (P \u3c 0.05); these changes were accompanied by a significant decrease in plasma high-density lipoprotein levels (P \u3c 0.05). The mRNA expression levels of desmin, tumor necrosis factor-alpha (TNF-alpha), nuclear factor kappaB (NFkappaB), and NAD(P)H oxidase-1 (NOX-1) were significantly higher in the renal cortical tissues of OZR-HFD animals; NFkappaB p65 DNA binding activity as determined by electrophoretic mobility shift assay was also significantly higher in these animals. The same trends were noted in LZR-HFD animals. Our data demonstrate that TEMPOL may prove beneficial in treating the early stages of the nephropathy often associated with MetS
- …
