1,479 research outputs found
Minimizing Symmetric Convex Functions over Hybrid of Continuous and Discrete Convex Sets
No full textWe study the problem of minimizing a given symmetric strictly convex function over the Minkowski sum of an integral base-polyhedron and an M-convex set. This problem has a hybrid of continuous and discrete structures. This emerges from the problem of allocating mixed goods, consisting of both divisible and indivisible goods, to agents with binary valuations so that the fairness measure, such as the Nash welfare, is maximized. It is known that both an integral base-polyhedron and an M-convex set have similar and nice properties, and the non-hybrid case can be solved in polynomial time. While the hybrid case lacks some of these properties, we show the structure of an optimal solution. Moreover, we exploit a proximity inherent in the problem. Through our findings, we demonstrate that our problem is NP-hard even in the fair allocation setting where all indivisible goods are identical. Moreover, we provide a polynomial-time algorithm for the fair allocation problem when all divisible goods are identical
Intramural pure pigment gallstones, a case report
No full textA case of intramural pure pigment gallstones, which were fortuitously found in post-mortem examination, is presented. The incidence, mechanism of formation of the stones and roentgenological diagnosis of the intramural gallstones, porcelain gall bladder, are mentioned.</p
Diagnosis, Treatment, and Management of COPD and Asthma
No full textChronic obstructive pulmonary disease (COPD) is a disorder characterized by airflow limitation and is one of the major causes of mortality and morbidity across the globe. Although several guidelines have been published over the past three decades, they were generated in response to the fact that COPD is a major cause of mortality and morbidity and remains an important social problem. In the 20th century, forced expiratory volume in one second (FEV1) was the single most important measure in patients with COPD from discriminative, evaluative, and predictive standpoints. We found that dyspnea is a better mortality predictor than FEV1 in 2002 and exercise capacity in 2003. Subsequently, it has become apparent that physical activity is more predictive of mortality. Furthermore, we have recently developed the tendency to use the reduction of the future risk of exacerbation as the endpoint of relatively large-scale clinical trials rather than the improvement of FEV1. Many researchers have continued to seek better outcome markers and have also discussed what should be used as primary or secondary endpoints in clinical trials in subjects with COPD. We have undoubtedly made great progress but still have a lot of work to do for the best interests of patients
STRESS TRANSFER MECHANISM OF COLUMN BASES OF COMPOSITE COLUMNS (PART 1)
No full textTo investigate stress transfer mechanism of base plate of composite columns with base; 13specimens were tested under monotonic and reversed loading. Experimental variable was chosenfor the amount of main reinforcement, applied axial load and with or without anchor bolts at base.Main discussion was concentrated on deformability, strain distribution of base plate and mainreinforcement and the failure mechanism.From the test results, it was showed that flexural strength of steel member was developed byproviding concrete and main reinforcement which restrains rotation of base plate and rising of con-crete. Also, the analytical model was formulated to estimate the strength of the test specimens andcomparisons were made between the calculated and experimental values.To investigate stress transfer mechanism of base plate of composite columns with base; 13specimens were tested under monotonic and reversed loading. Experimental variable was chosenfor the amount of main reinforcement, applied axial load and with or without anchor bolts at base.Main discussion was concentrated on deformability, strain distribution of base plate and mainreinforcement and the failure mechanism.From the test results, it was showed that flexural strength of steel member was developed byproviding concrete and main reinforcement which restrains rotation of base plate and rising of con-crete. Also, the analytical model was formulated to estimate the strength of the test specimens andcomparisons were made between the calculated and experimental values
DESIGN METHOD FOR MIXED STRUCTURES(PART 1, STRESS TRANSFER MECHANISM OF EXTERIOR JOINTS)
No full textThe object of this study is to make clear experimentally and theoretically the stresstransferring mechanism of exterior joints in mixed structures. Four specimens are testedunder reversed loading. The column is composed of steel and reinforced concrete and thebeam is made of steel. Experimental variable chosen is the ratio of the flexural strengthof steel element contained within composite column to the flexural strength of compositecolumn. Main discussion is concentrated on the failure mechanism, hysteretic characteristicsand the ultimate strength. On the basis of test results, the analytical model is suggestedand the ultimate strength formula based on the method of superposition shows a goodagreement with the experimental results.The object of this study is to make clear experimentally and theoretically the stresstransferring mechanism of exterior joints in mixed structures. Four specimens are testedunder reversed loading. The column is composed of steel and reinforced concrete and thebeam is made of steel. Experimental variable chosen is the ratio of the flexural strengthof steel element contained within composite column to the flexural strength of compositecolumn. Main discussion is concentrated on the failure mechanism, hysteretic characteristicsand the ultimate strength. On the basis of test results, the analytical model is suggestedand the ultimate strength formula based on the method of superposition shows a goodagreement with the experimental results
INELASTIC SHEAR BEHAVIOR OF RIGID MOMENT-RESISTING CONNECTIONS IN CRUCIFORM STEEL REINFORCED CONCRETE FRAMES (Part 3)
No full textAn experimental study is made to know the effect of working axial compression on the reductionof load carrying capacity of interior beam-to-column connection in steel reinforced concrete frames.Experimental variable is the ratio of applied axial compression to the ultimate compressive strength.Main discussion is concentrated on the shear strength, failure mechanism, strain history of webpanel and flange portion and hysteretic characteristics involved in the large deformation range undermonotonic and repeated loading. It is concluded that the load carrying capacity of beam-to-columnconnection that is supposed to fail in shear is hardly affected by magnitude of axial compressionon columnAn experimental study is made to know the effect of working axial compression on the reductionof load carrying capacity of interior beam-to-column connection in steel reinforced concrete frames.Experimental variable is the ratio of applied axial compression to the ultimate compressive strength.Main discussion is concentrated on the shear strength, failure mechanism, strain history of webpanel and flange portion and hysteretic characteristics involved in the large deformation range undermonotonic and repeated loading. It is concluded that the load carrying capacity of beam-to-columnconnection that is supposed to fail in shear is hardly affected by magnitude of axial compressionon colum
INELASTIC SHEAR BEHAVIOR OF RIGID MOMENT-RESISTING CONNECTIONS IN L-SHAPED STEEL REINFORCED CONCRETE FRAMES
No full textThe main objective of this investigation was to study the shear behavior of rigid moment-resisting connections in L-shaped SRC frames subjected to monotonic and well-defined alternatelyrepeated loading to deflection larger than the yield deflection. 16 specimens which were designedso as to prevent the flexural and shear failure of structural beam and column element were testedwith a variety of the ratio of beam width to column width, involving steel panel alone, concretepanel alone and steel-concrete panel. Main discussion was concentrated on the shear strength, deformability, hypothetical failure mechanism and shapes of hysteresis curves of connections.The analytical model was formulated to simulate the behavior of the test specimens and comparisonswere made between the calculated and observed behavior.The main objective of this investigation was to study the shear behavior of rigid moment-resisting connections in L-shaped SRC frames subjected to monotonic and well-defined alternatelyrepeated loading to deflection larger than the yield deflection. 16 specimens which were designedso as to prevent the flexural and shear failure of structural beam and column element were testedwith a variety of the ratio of beam width to column width, involving steel panel alone, concretepanel alone and steel-concrete panel. Main discussion was concentrated on the shear strength,deformability, hypothetical failure mechanism and shapes of hysteresis curves of connections.The analytical model was formulated to simulate the behavior of the test specimens and comparisonswere made between the calculated and observed behavior
INELASTIC SHEAR BEHAVIOR RIGID MOMENT-REGISTING CONNECTIONS IN CRUCIFORM-SHAPED STEEL REINFORCED CONCRETE FRAMES (PART 1)
No full textThe main objective of this investigation was to study the shear behavior of interior beam-to-column connections in steel reinforced concrete frames subjected to monotonic loading.Six specimens which were designed so as to prevent flexural and shear failure of beam andcolumn members were tested, whose connection panels were made of pure steel, pure concrete orsteel-and-concrete. The effects of the ratio of beam width to column width on the behavior ofconnections were investigated.The test results showed that the shear strength of interior connection was considerably largerthan that of exterior and corner connection which was previously conducted by authors and theshear strength increases with the increase of the ratio of beam width to column width. From thetest results, the empirical equation for the shear strength of beam-to-column connections wassuggested.The main objective of this investigation was to study the shear behavior of interior beam-to-column connections in steel reinforced concrete frames subjected to monotonic loading.Six specimens which were designed so as to prevent flexural and shear failure of beam andcolumn members were tested, whose connection panels were made of pure steel, pure concrete orsteel-and-concrete. The effects of the ratio of beam width to column width on the behavior ofconnections were investigated.The test results showed that the shear strength of interior connection was considerably largerthan that of exterior and corner connection which was previously conducted by authors and theshear strength increases with the increase of the ratio of beam width to column width. From thetest results, the empirical equation for the shear strength of beam-to-column connections wassuggested
Fate of adipocyte progenitors during adipogenesis in mice fed a high-fat diet
No full text富山大学博士（医学）Article富山大学・富医薬博甲第388号・MUHAMMAD BILAL・2022/03/23
公開論文
Muhammad Bilal, Allah Nawaz, Tomonobu Kado, Muhammad Rahil Aslam, Yoshiko Igarashi, Ayumi Nishimura, Yoshiyuki Watanabe, Takahide Kuwano, Jianhui Liu, Hiroyuki Miwa, Takumi Era, Koichi Ikuta, Johji Imura, Kunimasa Yagi, Takashi Nakagawa, Shiho Fujisaka, Kazuyuki Tobe,
Fate of adipocyte progenitors during adipogenesis in mice fed a high-fat diet,Molecular Metabolism,Volume 54,2021,101328,
ISSN 2212-8778,
https://doi.org/10.1016/j.molmet.2021.101328
- …
