10 research outputs found
On the nature of activity induced tissue oxygenation changes and blood flow responses in rat cerebellar cortex
No full textGesamtdissertationDie biologischen Grundlagen der neurometabolisch-neurovaskulären Kopplung des
Gehirns sind nicht hinreichend bekannt. Lokale Änderungen der
Nervenzellaktivität sind begleitet von regionalen Änderungen des zerebralen
Blutflusses (CBF) und bedienen die Bedürfnisse eines gesteigerten Metabolismus
in aktivierten Gehirnregionen und bilden zugleich die Grundlage funktionell-
bildgebender Verfahren des Gehirns. Es ist derzeit ein intensives Bestreben
die Mechanismen und die Art der neuronalen Aktivität zu klären, die diesen CBF
Anstieg vermitteln und die Frage nach den individuellen metabolischen Kosten
der an der Signaltransduktion beteiligten Prozesse und Zelltypen und die Art
ihrer Energiegewinnung zu klären. In welchem Umfang exzitatorische neuronale
Aktivierung zu einem gesteigerten Sauerstoffmetabolismus führt und in welcher
Relation zum CBF, wird ebenso kontrovers diskutiert wie die Frage nach dem
Regulationsprinzip und dem initialen Auslöser der Kopplungskaskade. Die
Bedeutung inhibitorischer Einflüsse auf Energieverbrauch und CBF wurde bisher
kaum untersucht. Ziel der vorgestellten Arbeiten war es, die
neurophysiologische Grundlage aktivitätsinduzierter metabolischer und
hämodynamischer Antworten im zerebellären Kortex der Ratte zu spezifizieren.
Es wurde die Bedeutung von Variationen der synaptischen exzitatorischer
Aktivität im Vergleich zur Veränderung der Aktionspotentialrate für die
Induktion der CBF Antworten und den Sauerstoffverbrauch untersucht, die
Relation der Antworten zueinander, sowie deren Beeinflussbarkeit durch
Veränderungen des synaptischen inhibitorischen Tonus. Die kombinierte,
dynamische Erfassung von Veränderungen des CBF, des
Gewebssauerstoffpartialdruckes (tpO2) und der neuronalen Aktivität (mittels
Laser-Doppler Flussmessung, Sauerstoff- und Glas-Mikroelektroden;
Kletterfaser-Stimulation) ermöglichte es, die Beziehung der Signalantworten
zueinander zu etablieren und die Abhängigkeit des tpO2 Signals von
Sauerstoffverbrauch und CBF Antwort zu demonstrieren. Durch pharmakologische
Disinhibition konnte gezeigt werden, dass im Zerebellum der Blutfluss
unabhängig von der spontanen Aktionspotentialrate in Purkinje-Zellen ist und
Aktionspotentialrate und hämodynamische Antwort in aktivierten Hirnregionen
somit nicht proportional sein müssen. Blutflussanstieg und Sauerstoffverbrauch
bedurften andererseits der postsynaptischen Aktivierung neuronaler ionotroper
Glutamatrezeptoren. Zugleich erfuhren die stimulationsinduzierten Anstiege im
CBF und Sauerstoffverbrauch eine gleichsinnige Modifikation bei Variation des
inhibitorischen synaptischen Tonus. Zusammen liefern diese Studien
experimentelle Evidenz für die hypothetisierte Vorwärts-vermittelte (engl.:
Feed-forward) Regulation der neurometabolischen und neurovaskulären Kopplung
und weisen auf eine in Folge der glutamatergen Signaltransduktion an
exzitatorischen Synapsen initiierte neuronale Signalkaskade hin, die letzten
Endes sowohl in der Steigerung des Blutfluss mündet, als auch im Anstieg des
Sauerstoffmetabolismus.In the normal brain, local variations in nerve cell activity are accompanied
by regional changes in cerebral blood flow (CBF) and serve to sustain
increased energy metabolism within activated brain regions. This neurovascular
and neurometabolic coupling ensures energy homeostasis of the brain and is the
basis of signals used in functional neuroimaging to map brain function non-
invasively. There is a great effort to elucidate the mechanisms mediating
activity induced blood flow increases and to determine the type of neuronal
activity underlying evoked haemodynamic responses and to clarify the
individual energetic costs of the different processes and cell types involved
in information transfer and processing. To which extend transient changes in
excitatory neurotransmission are associated with increases in oxygen
consumption is under debate and the exact relationship between increases in
blood flow and oxygen metabolism is unknown. Furthermore, there is a lack of
studies on the influence of neuronal inhibition on energy consumption and CBF.
Generally, the basic principle of neurovascular and neurometabolic coupling
and the initial trigger for CBF and oxygen consumption increases need to be
determined. Aim of the studies was to specify the neurophysiological basis of
activity induced metabolic and haemodynamic responses in rat cerebellar
cortex. The relevance of changes in synaptic excitatory input or spiking-
output for changes in CBF and tissue oxygenation was investigated and the
relation between activity induced changes in synaptic activity, blood flow and
tissue oxygenation was studied. Lastly, the effect of variations in GABAergic
tone on local oxygen consumption and blood flow evoked by synaptic excitation
was investigated. Concurrent measures of neuronal activity by glass
microelectrodes and changes in tissue oxygen partial pressure (tpO2) by
polarographic microelectrodes and CBF by laser-Doppler flowmetry were made and
response magnitudes for different levels of activation were calculated.
Thereby the interrelation of the signal responses could be established. TpO2
responses within the activated region were shown to be the result of a
temporally staggered interplay of oxygen consumption induced by synaptic
excitation and increased oxygen supply due to the rise in CBF. By
pharmacological disinhibition the studies showed that an isolated increase in
Purkinje cell spike activity is not sufficient to increase CBF and
demonstrated that changes in spike activity and CBF not necessarily have to be
proportional. Importantly, activity induced rises in CBF and oxygen
consumption were both shown to be dependent on postsynaptic excitatory
activity. Moreover, CBF and oxygen consumption underwent similar modification
by shifting inhibitory GABAergic tone. Taken together, the studies of this
work provide experimental evidence for the hypothesized feed-forward
regulation of neurometabolic and neurovascular coupling and support the idea
of glutamatergic neurotransmission as being a common trigger of signalling
cascades finally giving rise to blood flow and oxygen consumption increases
within activated brain regions
Principle neuron spiking: neither necessary nor sufficient for cerebral blood flow at rest or during activation in rat cerebellum
No full textActivity-induced tissue oxygenation changes in rat cerebellar cortex: interplay of postsynaptic activation and blood flow
No full text
Pathway-specific variations in neurovascular and neurometabolic coupling in rat primary somatosensory cortex
No full textFunctional neuroimaging signals are generated, in part, by increases in cerebral blood flow (CBF) evoked by mediators, such as nitric oxide and arachidonic acid derivatives that are released in response to increased neurotransmission. However, it is unknown whether the vascular and metabolic responses within a given brain area differ when local neuronal activity is evoked by an activity in the distinct neuronal networks. In this study we assessed, for the first time, the differences in neuronal responses and changes in CBF and oxygen consumption that are evoked after the activation of two different inputs to a single cortical area. We show that, for a given level of glutamatergic synaptic activity, corticocortical and thalamocortical inputs evoked activity in pyramidal cells and different classes of interneurons, and produced different changes in oxygen consumption and CBF. Furthermore, increases in stimulation intensities either turned off or activated additional classes of inhibitory interneurons immunoreactive for different vasoactive molecules, which may contribute to increases in CBF. Our data imply that for a given cortical area, the amplitude of vascular signals will depend critically on the type of input, and that a positive blood oxygen level-dependent (BOLD) signal may be a consequence of the activation of both pyramidal cells and inhibitory interneurons
Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain
No full text
Modern functional imaging techniques of the brain measure local hemodynamic responses evoked by neuronal activity. Capillary pericytes recently were suggested to mediate neurovascular coupling in brain slices, but their role in vivo remains unexplored. We used two-photon microscopy to study in real time pericytes and the dynamic changes of capillary diameter and blood flow in the cortex of anesthetized mice, as well as in brain slices. The thromboxane A
2
analog, 9,11-dideoxy-9α,11α-methanoepoxy Prostaglandin F2α (U46619), induced constrictions in the vicinity of pericytes in a fraction of capillaries, whereas others dilated. The changes in vessel diameter resulted in changes in capillary red blood cell (RBC) flow. In contrast, during brief epochs of seizure activity elicited by local administration of the GABA
A
receptor antagonist, bicuculline, capillary RBC flow increased without pericyte-induced capillary diameter changes. Precapillary arterioles were the smallest vessels to dilate, together with penetrating and pial arterioles. Our results provide in vivo evidence that pericytes can modulate capillary blood flow in the brain, which may be important under pathological conditions. However, our data suggest that precapillary and penetrating arterioles, rather than pericytes in capillaries, are responsible for the blood flow increase induced by neural activity.
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Visualization of perfusion changes with laser speckle contrast imaging using the method of motion history image
Get PDFLaser speckle contrast imaging (LSCI) is a real-time imaging modality reflecting microvascular perfusion. We report on the application of the motion history image (MHI) method on LSCI data obtained from the two hemispheres of a mouse. Through the generation of a single image, MHI stresses the microvascular perfusion changes. Our experimental results performed during a pinprick-triggered spreading depolarization demonstrate the effectiveness of MHI: MHI allows the visualization of perfusion changes without loss of resolution and definition. Moreover, MHI provides close results to the ones given by the generalized differences (GD) algorithm. However, MHI has the advantage of giving information on the temporal evolution of the perfusion variations, which GD does not
Is spreading depolarization characterized by an abrupt, massive release of gibbs free energy from the human brain cortex?
Get PDFIn the evolution of the cerebral cortex, the sophisticated organization in a steady state far away from thermodynamic equilibrium has produced the side effect of two fundamental pathological network events: ictal epileptic activity and spreading depolarization. Ictal epileptic activity describes the partial disruption, and spreading depolarization describes the near-complete disruption of the physiological double Gibbs-Donnan steady state. The occurrence of ictal epileptic activity in patients has been known for decades. Recently, unequivocal electrophysiological evidence has been found in patients that spreading depolarizations occur abundantly in stroke and brain trauma. The authors propose that the ion changes can be taken to estimate relative changes in Gibbs free energy from state to state. The calculations suggest that in transitions from the physiological state to ictal epileptic activity to spreading depolarization to death, the cortex releases Gibbs free energy in a stepwise fashion. Spreading depolarization thus appears as a twilight state close to death. Consistently, electrocorticographic recordings in the core of focal ischemia or after cardiac arrest display a smooth transition from the initial spreading depolarization component to the later ultraslow negative potential, which is assumed to reflect processes in cellular death. © The Author(s) 2013.Peer Reviewe
Proceedings of the 4th World Conference on Research Integrity
Get PDFFor a complete list of authors, please look at article.Table of contents
I1 Proceedings of the 4th World Conference on Research Integrity
Concurrent Sessions:
1. Countries' systems and policies to foster research integrity
CS01.1 Second time around: Implementing and embedding a review of responsible conduct of research policy and practice in an Australian research-intensive university
Susan Patricia O'Brien
CS01.2 Measures to promote research integrity in a university: the case of an Asian university
Danny Chan, Frederick Leung
2. Examples of research integrity education programmes in different countries
CS02.1 Development of a state-run “cyber education program of research ethics” in Korea
Eun Jung Ko, Jin Sun Kwak, TaeHwan Gwon, Ji Min Lee, Min-Ho Lee
CS02.3 Responsible conduct of research teachers’ training courses in Germany: keeping on drilling through hard boards for more RCR teachers
Helga Nolte, Michael Gommel, Gerlinde Sponholz
3. The research environment and policies to encourage research integrity
CS03.1 Challenges and best practices in research integrity: bridging the gap between policy and practice
Yordanka Krastev, Yamini Sandiran, Julia Connell, Nicky Solomon
CS03.2 The Slovenian initiative for better research: from national activities to global reflections
Ursa Opara Krasovec, Renata Sribar
CS03.3 Organizational climate assessments to support research integrity: background of the Survey of Organizational Research Climate (SOuRCe) and the experience with its use at Michigan State University
Brian C. Martinson, Carol R. Thrush, C.K. Gunsalus
4. Expressions of concern and retractions
CS04.1 Proposed guidelines for retraction notices and their dissemination
Ivan Oransky, Adam Marcus
CS04.2 Watching retractions: analysis of process and practice, with data from the Wiley retraction archives
Chris Graf, Verity Warne, Edward Wates, Sue Joshua
CS04.3 An exploratory content analysis of Expressions of Concern
Miguel Roig
CS04.4 An ethics researcher in the retraction process
Michael Mumford
5. Funders' role in fostering research integrity
CS05.1 The Fonds de Recherche du Québec’s institutional rules on the responsible conduct of research: introspection in the funding agency activities
Mylène Deschênes, Catherine Olivier, Raphaëlle Dupras-Leduc
CS05.2 U.S. Public Health Service funds in an international setting: research integrity and compliance
Zoë Hammatt, Raju Tamot, Robin Parker, Cynthia Ricard, Loc Nguyen-Khoa, Sandra Titus
CS05.3 Analyzing decision making of funders of public research as a case of information asymmetry
Karsten Klint Jensen
CS05.4 Research integrity management: Empirical investigation of academia versus industry
Simon Godecharle, Ben Nemery, Kris Dierickx
5A: Education: For whom, how, and what?
CS05A.1 Research integrity or responsible conduct of research? What do we aim for?
Mickey Gjerris, Maud Marion Laird Eriksen, Jeppe Berggren Hoej
CS05A.2 Teaching and learning about RCR at the same time: a report on Epigeum’s RCR poll questions and other assessment activities
Nicholas H. Steneck
CS05A.4 Minding the gap in research ethics education: strategies to assess and improve research competencies in community health workers/promoteres
Camille Nebeker, Michael Kalichman, Elizabeth Mejia Booen, Blanca Azucena Pacheco, Rebeca Espinosa Giacinto, Sheila Castaneda
6. Country examples of research reward systems and integrity
CS06.1 Improving systems to promote responsible research in the Chinese Academy of Sciences
Ding Li, Qiong Chen, Guoli Zhu, Zhonghe Sun
CS06.4 Exploring the perception of research integrity amongst public health researchers in India
Parthasarathi Ganguly, Barna Ganguly
7. Education and guidance on research integrity: country differences
CS07.1 From integrity to unity: how research integrity guidance differs across universities in Europe.
Noémie Aubert Bonn, Kris Dierickx, Simon Godecharle
CS07.2 Can education and training develop research integrity? The spirit of the UNESCO 1974 recommendation and its updating
Daniele Bourcier, Jacques Bordé, Michèle Leduc
CS07.3 The education and implementation mechanisms of research ethics in Taiwan's higher education: an experience in Chinese web-based curriculum development for responsible conduct of research
Chien Chou, Sophia Jui-An Pan
CS07.4 Educating principal investigators in Swiss research institutions: present and future perspectives
Louis Xaver Tiefenauer
8. Measuring and rewarding research productivity
CS08.1 Altimpact: how research integrity underpins research impact
Daniel Barr, Paul Taylor
CS08.2 Publication incentives: just reward or misdirection of funds?
Lyn Margaret Horn
CS08.3 Why Socrates never charged a fee: factors contributing to challenges for research integrity and publication ethics
Deborah Poff
9. Plagiarism and falsification: Behaviour and detection
CS09.1 Personality traits predict attitude towards plagiarism of self and others in biomedicine: plagiarism, yes we can?
Martina Mavrinac, Gordana Brumini, Mladen Petrovečki
CS09.2 Investigating the concept of and attitudes toward plagiarism for science teachers in Brazil: any challenges for research integrity and policy?
Christiane Coelho Santos, Sonia Vasconcelos
CS09.3 What have we learnt?: The CrossCheck Service from CrossRef
Rachael Lammey
CS09.4 High p-values as a sign of data fabrication/falsification
Chris Hartgerink, Marcel van Assen, Jelte Wicherts
10. Codes for research integrity and collaborations
CS10.1 Research integrity in cross-border cooperation: a Nordic example
Hanne Silje Hauge
CS10.3 Research integrity, research misconduct, and the National Science Foundation's requirement for the responsible conduct of research
Aaron Manka
CS10.4 A code of conduct for international scientific cooperation: human rights and research integrity in scientific collaborations with international academic and industry partners
Raffael Iturrizaga
11. Countries' efforts to establish mentoring and networks
CS11.1 ENRIO (European Network of Research Integrity Offices): a network facilitating common approaches on research integrity in Europe
Nicole Foeger
CS11.2 Helping junior investigators develop in a resource-limited country: a mentoring program in Peru
A. Roxana Lescano, Claudio Lanata, Gissella Vasquez, Leguia Mariana, Marita Silva, Mathew Kasper, Claudia Montero, Daniel Bausch, Andres G Lescano
CS11.3 Netherlands Research Integrity Network: the first six months
Fenneke Blom, Lex Bouter
CS11.4 A South African framework for research ethics and integrity for researchers, postgraduate students, research managers and administrators
Laetus OK Lategan
12. Training and education in research integrity at an early career stage
CS12.1 Research integrity in curricula for medical students
Gustavo Fitas Manaia
CS12.2 Team-based learning for training in the responsible conduct of research supports ethical decision-making
Wayne T. McCormack, William L. Allen, Shane Connelly, Joshua Crites, Jeffrey Engler, Victoria Freedman, Cynthia W. Garvan, Paul Haidet, Joel Hockensmith, William McElroy, Erik Sander, Rebecca Volpe, Michael F. Verderame
CS12.4 Research integrity and career prospects of junior researchers
Snezana Krstic
13. Systems and research environments in institutions
CS13.1 Implementing systems in research institutions to improve quality and reduce risk
Louise Handy
CS13.2 Creating an institutional environment that supports research integrity
Debra Schaller-Demers
CS13.3 Ethics and Integrity Development Grants: a mechanism to foster cultures of ethics and integrity
Paul Taylor, Daniel Barr
CS13.4 A culture of integrity at KU Leuven
Inge Lerouge, Gerard Cielen, Liliane Schoofs
14. Peer review and its role in research integrity
CS14.1 Peer review research across disciplines: transdomain action in the European Cooperation in Science and Technology (COST) “New Frontiers of Peer Review (PEERE)”
Ana Marusic, Flaminio Squazzoni
CS14.2 Using blinding to reduce bias in peer review
David Vaux
CS14.3 How to intensify the role of reviewers to promote research integrity
Khalid Al-Wazzan, Ibrahim Alorainy
CS14.4 Credit where credit’s due: professionalizing and rewarding the role of peer reviewer
Chris Graf, Verity Warne
15. Research ethics and oversight for research integrity: Does it work?
CS15.1 The psychology of decision-making in research ethics governance structures: a theory of bounded rationality
Nolan O'Brien, Suzanne Guerin, Philip Dodd
CS15.2 Investigator irregularities: iniquity, ignorance or incompetence?
Frank Wells, Catherine Blewett
CS15.3 Academic plagiarism
Fredric M. Litto
16. Research integrity in Europe
CS16.1 Whose responsibility is it anyway?: A comparative analysis of core concepts and practice at European research-intensive universities to identify and develop good practices in research integrity
Itziar De Lecuona, Erika Löfstrom, Katrien Maes
CS16.2 Research integrity guidance in European research universities
Kris Dierickx, Noémie Bonn, Simon Godecharle
CS16.3 Research Integrity: processes and initiatives in Science Europe member organisations
Tony Peatfield, Olivier Boehme, Science Europe Working Group on Research Integrity
CS16.4 Promoting research integrity in Italy: the experience of the Research Ethics and Bioethics Advisory Committee of the Consiglio Nazionale delle Ricerche (CNR)
Cinzia Caporale, Daniele Fanelli
17. Training programs for research integrity at different levels of experience and seniority
CS17.1 Meaningful ways to incorporate research integrity and the responsible conduct of research into undergraduate, graduate, postdoctoral and faculty training programs
John Carfora, Eric Strauss, William Lynn
CS17.2 "Recognize, respond, champion": Developing a one-day interactive workshop to increase confidence in research integrity issues
Dieter De Bruyn, Bracke Nele, Katrien De Gelder, Stefanie Van der Burght
CS17.4 “Train the trainer” on cultural challenges imposed by international research integrity conversations: lessons from a project
José Roberto Lapa e Silva, Sonia M. R. Vasconcelos
18. Research and societal responsibility
CS18.1 Promoting the societal responsibility of research as an integral part of research integrity
Helene Ingierd
CS18.2 Social responsibility as an ethical imperative for scientists: research, education and service to society
Mark Frankel
CS18.3 The intertwined nature of social responsibility and hope in science
Daniel Vasgird, Stephanie Bird
CS18.4 Common barriers that impede our ability to create a culture of trustworthiness in the research community
Mark Yarborough
19. Publication ethics
CS19.1 The authors' forum: A proposed tool to improve practices of journal editors and promote a responsible research environment
Ibrahim Alorainy, Khalid Al-Wazzan
CS19.2 Quantifying research integrity and its impact with text analytics
Harold Garner
CS19.3 A closer look at authorship and publication ethics of multi- and interdisciplinary teams
Lisa Campo-Engelstein, Zubin Master, Elise Smith, David Resnik, Bryn Williams-Jones
CS19.4 Invisibility of duplicate publications in biomedicine
Mario Malicki, Ana Utrobicic, Ana Marusic
20. The causes of bad and wasteful research: What can we do?
CS20.1 From countries to individuals: unravelling the causes of bias and misconduct with multilevel meta-meta-analysis
Daniele Fanelli, John PA Ioannidis
CS20.2 Reducing research waste by integrating systems of oversight and regulation
Gerben ter Riet, Tom Walley, Lex Marius Bouter
CS20.3 What are the determinants of selective reporting?: The example of palliative care for non-cancer conditions
Jenny van der Steen, Lex Bouter
CS20.4 Perceptions of plagiarism, self-plagiarism and redundancy in research: preliminary results from a national survey of Brazilian PhDs
Sonia Vasconcelos, Martha Sorenson, Francisco Prosdocimi, Hatisaburo Masuda, Edson Watanabe, José Carlos Pinto, Marisa Palácios, José Lapa e Silva, Jacqueline Leta, Adalberto Vieyra, André Pinto, Mauricio Sant’Ana, Rosemary Shinkai
21. Are there country-specific elements of misconduct?
CS21.1 The battle with plagiarism in Russian science: latest developments
Boris Yudin
CS21.2 Researchers between ethics and misconduct: A French survey on social representations of misconduct and ethical standards within the scientific community
Etienne Vergès, Anne-Sophie Brun-Wauthier, Géraldine Vial
CS21.3 Experience from different ways of dealing with research misconduct and promoting research integrity in some Nordic countries
Torkild Vinther
CS21.4 Are there specifics in German research misconduct and the ways to cope with it?
Volker Bähr, Charité
22. Research integrity teaching programmes and their challenges
CS22.1 Faculty mentors and research integrity
Michael Kalichman, Dena Plemmons
CS22.2 Training the next generation of scientists to use principles of research quality assurance to improve data integrity and reliability
Rebecca Lynn Davies, Katrina Laube
CS22.3 Fostering research integrity in a culturally-diverse environment
Cynthia Scheopner, John Galland
CS22.4 Towards a standard retraction form
Hervé Maisonneuve, Evelyne Decullier
23. Commercial research and integrity
CS23.1 The will to commercialize: matters of concern in the cultural economy of return-on-investment research
Brian Noble
CS23.2 Quality in drug discovery data reporting: a mission impossible?
Anja Gilis, David J. Gallacher, Tom Lavrijssen, Malwitz David, Malini Dasgupta, Hans Mols
CS23.3 Instituting a research integrity policy in the context of semi-private-sector funding: an example in the field of occupational health and safety
Paul-Emile Boileau
24. The interface of publication ethics and institutional policies
CS24.1 The open access ethical paradox in an open government effort
Tony Savard
CS24.2 How journals and institutions can work together to promote responsible conduct
Eric Mah
CS24.3 Improving cooperation between journals and research institutions in research integrity cases
Elizabeth Wager, Sabine Kleinert
25. Reproducibility of research and retractions
CS25.1 Promoting transparency in publications to reduce irreproducibility
Veronique Kiermer, Andrew Hufton, Melanie Clyne
CS25.2 Retraction notices issued for publications by Latin American authors: what lessons can we learn?
Sonia Vasconcelos, Renan Moritz Almeida, Aldo Fontes-Pereira, Fernanda Catelani, Karina Rocha
CS25.3 A preliminary report of the findings from the Reproducibility Project: Cancer biology
Elizabeth Iorns, William Gunn
26. Research integrity and specific country initiatives
CS26.1 Promoting research integrity at CNRS, France
Michèle Leduc, Lucienne Letellier
CS26.2 In pursuit of compliance: is the tail wagging the dog?
Cornelia Malherbe
CS26.3 Newly established research integrity policies and practices: oversight systems of Japanese research universities
Takehito Kamata
27. Responsible conduct of research and country guidelines
CS27.1 Incentives or guidelines? Promoting responsible research communication through economic incentives or ethical guidelines?
Vidar Enebakk
CS27.3 Responsible conduct of research: a view from Canada
Lynn Penrod
CS27.4 The Danish Code of Conduct for Research Integrity: a national initiative to promote research integrity in Denmark
Thomas Nørgaard, Charlotte Elverdam
28. Behaviour, trust and honesty
CS28.1 The reasons behind non-ethical behaviour in academia
Yves Fassin
CS28.2 The psychological profile of the dishonest scholar
Cynthia Fekken
CS28.3 Considering the implications of Dan Ariely’s keynote speech at the 3rd World Conference on Research Integrity in Montréal
Jamal Adam, Melissa S. Anderson
CS28.4 Two large surveys on psychologists’ views on peer review and replication
Jelte Wicherts
Brett Buttliere
29. Reporting and publication bias and how to overcome it
CS29.1 Data sharing: Experience at two open-access general medical journals
Trish Groves
CS29.2 Overcoming publication bias and selective reporting: completing the published record
Daniel Shanahan
CS29.3 The EQUATOR Network: promoting responsible reporting of health research studies
Iveta Simera, Shona Kirtley, Eleana Villanueva, Caroline Struthers, Angela MacCarthy, Douglas Altman
30. The research environment and its implications for integrity
CS30.1 Ranking of scientists: the Russian experience
Elena Grebenshchikova
CS30.4 From cradle to grave: research integrity, research misconduct and cultural shifts
Bronwyn Greene, Ted Rohr
PARTNER SYMPOSIA
Partner Symposium A
Organized by EQUATOR Network, Enhancing the Quality and Transparency of Health Research
P1 Can we trust the medical research literature?: Poor reporting and its consequences
Iveta Simera
P2 What can BioMed Central do to improve published research?
Daniel Shanahan, Stephanie Harriman
P3 What can a "traditional" journal do to improve published research?
Trish Groves
P4 Promoting good reporting practice for reliable and usable research papers: EQUATOR Network, reporting guidelines and other initiatives
Caroline Struthers
Partner Symposium C
Organized by ENRIO, the European Network of Research Integrity Officers
P5 Transparency and independence in research integrity investigations in Europe
Krista Varantola, Helga Nolte, Ursa Opara, Torkild Vinther, Elizabeth Wager, Thomas Nørgaard
Partner Symposium D
Organized by IEEE, the Institute of Electrical and Electronics Engineers
Re-educating our author community: IEEE's approach to bibliometric manipulation, plagiarism, and other inappropriate practices
P6 Dealing with plagiarism in the connected world: An Institute of Electrical and Electronics Engineers (IEEE) perspective
Jon Rokne
P7 Should evaluation of raises, promotion, and research proposals be tied to bibliometric indictors? What the Institute of Electrical and Electronics Engineers (IEEE) is doing to answer this question
Gianluca Setti
P8 Recommended practices to ensure conference content quality
Gordon MacPherson
Partner Symposium E
Organized by the Committee on Freedom and Responsibility in the Conduct of Science of ICSU, the International Council for Science
