57 research outputs found

    sj-docx-1-msj-10.1177_13524585231208310 – Supplemental material for Smoking during pregnancy and risk of multiple sclerosis in offspring and mother: A Danish nationwide register-based cohort study

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    Supplemental material, sj-docx-1-msj-10.1177_13524585231208310 for Smoking during pregnancy and risk of multiple sclerosis in offspring and mother: A Danish nationwide register-based cohort study by Nete Munk Nielsen, Morten Frisch, Sanne Gørtz, Egon Stenager, Kristin Skogstrand, David M Hougaard, Alberto Ascherio, Klaus Rostgaard and Henrik Hjalgrim in Multiple Sclerosis Journal</p

    Emerg Infect Dis

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    In anticipation of licensure and introduction of rotavirus vaccine into the western market, we used modeling of national hospital registry data to determine the incidence and direct medical costs of annual rotavirus-associated admissions over >11 years in Denmark. Diarrhea-associated hospitalizations coded as nonspecified viral or presumed infectious have demonstrated a marked winter peak similar to that of rotavirus-associated hospitalizations, which suggests that the registered rotavirus-coded admissions are grossly underestimated. We therefore obtained more realistic estimates by 2 different models, which indicated 2.4 and 2.5 (for children <5 years of age) and 4.9 and 5.3 (for children <2 years of age) rotavirus-associated admissions per 1,000 children per year, respectively. These admissions amount to associated direct medical costs of US $1.7-1.8 million per year. Using 2 simple models to analyze readily available hospital discharge data resulted in more consistent and reliable estimates

    Incidence and Cost of Rotavirus Hospitalizations in Denmark

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    In anticipation of licensure and introduction of rotavirus vaccine into the western market, we used modeling of national hospital registry data to determine the incidence and direct medical costs of annual rotavirus-associated admissions over <11 years in Denmark. Diarrhea-associated hospitalizations coded as nonspecified viral or presumed infectious have demonstrated a marked winter peak similar to that of rotavirus-associated hospitalizations, which suggests that the registered rotavirus-coded admissions are grossly underestimated. We therefore obtained more realistic estimates by 2 different models, which indicated ≈2.4 and ≈2.5 (for children <5 years of age) and ≈4.9 and ≈5.3 (for children <2 years of age) rotavirus-associated admissions per 1,000 children per year, respectively. These admissions amount to associated direct medical costs of US $1.7–1.8 million per year. Using 2 simple models to analyze readily available hospital discharge data resulted in more consistent and reliable estimates

    Same-sex marriage, autoimmune thyroid gland dysfunction and other autoimmune diseases in Denmark 1989-2008

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    Autoimmune diseases have been little studied in gay men and lesbians. We followed 4.4 million Danes, including 9,615 same-sex married (SSM) persons, for 47 autoimmune diseases in the National Patient Registry between 1989 and 2008. Poisson regression analyses provided first hospitalization rate ratios (RRs) comparing rates between SSM individuals and persons in other marital status categories. SSM individuals experienced no unusual overall risk of autoimmune diseases. However, the risk of autoimmune thyroid dysfunction was increased, notably Hashimoto's thyroiditis (womenSSM, RR = 2.92; 95 % confidence interval (CI) 1.74-4.55) and Graves' disease (menSSM, RR = 1.88; 95 % CI 1.08-3.01). There was also an excess of primary biliary cirrhosis (womenSSM, RR = 4.09; 95 % CI 1.01-10.7), and of psoriasis (menSSM, RR = 2.48; 95 % CI 1.77-3.36), rheumatic fever (menSSM, RR = 7.55; 95 % CI 1.87-19.8), myasthenia gravis (menSSM, RR = 5.51; 95 % CI 1.36-14.4), localized scleroderma (menSSM, RR = 7.16; 95 % CI 1.18-22.6) and pemphigoid (menSSM, RR = 6.56; 95 % CI 1.08-20.6), while Dupuytren's contracture was reduced (menSSM, RR = 0.64; 95 % CI 0.39-0.99). The excess of psoriasis was restricted to same-sex married men with HIV/AIDS (menSSM, RR = 10.5; 95 % CI 6.44-15.9), whereas Graves' disease occurred in excess only among same-sex married men without HIV/AIDS (menSSM, RR = 1.99; 95 % CI 1.12-3.22). Lesbians and immunologically competent gay men in same-sex marriage face no unusual overall risk of autoimmune diseases. However, the observed increased risk of thyroid dysfunction in these lesbians and gay men deserves further study.</p

    [Detection of rotavirus infection in Danish children]

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    Rotavirus (RV) is the most frequent causative agent of severe diarrhoea in infants and young children worldwide, also in Denmark. However, the actual number of diagnosed RV cases among Danish children is unknown. If a new RV-vaccine is to be introduced in Denmark, updated data on RV disease burden is important and the validity of potential surveillance systems needs to be explored

    Author Correction:Vitamin D status and severity of COVID-19 (Scientific Reports, (2022), 12, 1, (19823), 10.1038/s41598-022-21513-9)

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    Sanne Grundvald Boelt was omitted from the author list in the original version of this Article. The Author Contributions section now reads: “A.A. contributed to the conception and idea of the work. N.M.N., A.S.C., L.B. and A.A. contributed to the design of the study. N.M.N., A.S.C., L.B. S.G.B contributed to the acquisition of data. N.M.N., A.H., L.B., S.G.B and T.G.J. contributed to the analyses of the data. All authors contributed to the interpretation of the data and the results in the manuscript. N.M.N. drafted the manuscript, made Fig. 1, T.G.J. made Fig. 2. All the authors revised the manuscript critically and has approved the final version.” The original Article has been corrected.</p
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