1,720,995 research outputs found
Diagnosis and therapy of conjunctival tumors [Diagnosi e terapia delle lesioni neoplastiche congiuntivali]
No full text[Use of dermo-adipose grafts in facial morphology restoration in cases of progressive partial lipodystrophy]
No full textIL BODY CONTOURING ATTRAVERSO GLI ULTRASUONI ESTERNI A BASSA FREQUENZA. EFFICACIA DELLA TECNICA XUAL
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Eyelid neoplasms: Case reports [La patologia neoplastica palpebrale mnella nostra esperienza]
No full textInsulitis in Human Type 1 Diabetic Pancreas: From Stem Cell Grafting to Islet Organoids for a Successful Cell-Based Therapy
No full textType 1 diabetes (T1D) is an autoimmune disease with immune cells' islet infiltration (called "insulitis"), which leads to beta cell loss. Despite being the critical element of T1D occurrence and pathogenesis, insulitis is often present in a limited percentage of islets, also at diagnosis. Therefore, it is needed to define reproducible methods to detect insulitis and beta-cell decline, to allow accurate and early diagnosis and to monitor therapy. However, this goal is still far due to the morphological aspect of islet microvasculature, which is rather dense and rich, and is considerably rearranged during insulitis. More studies on microvasculature are required to understand if contrast-enhanced ultrasound sonography measurements of pancreatic blood-flow dynamics may provide a clinically deployable predictive marker to predict disease progression and therapeutic reversal in pre-symptomatic T1D patients. Therefore, it is needed to clarify the relation between insulitis and the dynamics of β cell loss and with coexisting mechanisms of dysfunction, according to clinical stage, as well as the micro vessels' dynamics and microvasculature reorganization. Moreover, the ideal cell-based therapy of T1D should start from an early diagnosis allowing a sufficient isolation of specific Procr+ progenitors, followed by the generation and expansion of islet organoids, which could be transplanted coupled to an immune-regulatory therapy which will permit the maintenance of pancreatic islets and an effective and long-lasting insulitis reversa
Evaluation of endothelial progenitor cells as cardiovascular prognostic biomarkers in hemodialysis patients
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