87 research outputs found
Integration of Stimulated Raman Histology (SRH) into intraoperative neuropathology in neurosurgery : Köln, Deutschland. DGNC 2022
No full textT-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10 : Freiburg, Deutschland. Berta-Ottenstein-Symposium 2022
No full textIntraoperative differentiation between Glioblastoma and CNS-Lymphoma by AI-based analysis of stimulated raman histology (SRH)
No full textT-Cell Dysfunction in the Glioblastoma Microenvironment is Mediated by Myeloid Cells Releasing Interleukin-10 : Florenz, Italien: EANS Research Course 2022
No full text
Untersuchung zur TGFb1-vermittelten Expression von Olfml3 und Tmem119 in Mikroglia-Zellen
No full textT-Cell Dysfunction in the Glioblastoma Microenvironment is Mediated by Myeloid Cells Releasing Interleukin-10 : Belgrad, Serbien: EANS Congress 2022
No full textDexamethasone in Patients with Glioblastoma: A Systematic Review and Meta-Analysis.
No full textOBJECTIVE
Glioblastomas are the most common primary central nervous system (CNS) tumors. Although modern management strategies have modestly improved overall survival, the prognosis remains dismal, with treatment side effects often impinging on the clinical course. Glioblastomas cause neurological dysfunction by infiltrating CNS tissue and via perifocal oedema formation. The administration of steroids such as dexamethasone is thought to alleviate symptoms by reducing oedema. However, despite its widespread use, the evidence for the administration of dexamethasone is limited and conflicting. Therefore, we aimed to review the current evidence concerning the use and outcomes of dexamethasone in patients with glioblastoma.
METHODS
We performed a systematic review and meta-analysis according to the PRISMA-P guidelines. We performed a restricted search using the keywords "Dexamethasone" and "Glioblastoma" on PubMed, Web of Science, Cochrane Library, and Academic Search Premier. We included studies reporting on overall survival (OS) and progression-free survival (PFS) in glioblastoma patients receiving higher or lower dexamethasone doses. The risk of bias was assessed using ROBINS-I. We performed a meta-analysis using a random effects model for OS and PFS.
RESULTS
Twenty-two retrospective studies were included. Higher doses of dexamethasone were associated with poorer OS (hazard ratio 1.62, confidence interval 1.40-1.88) and PFS (1.49, 1.23-1.81). OS remained worse even when studies corrected for clinical status (1.52, 1.38-1.67).
CONCLUSION
Despite the widespread use of dexamethasone in glioblastoma patients, its use is correlated with worse long-term outcomes. Consequently, Dexamethasone administration should be restricted to selected symptomatic patients. Future prospective studies are crucial to confirm these findings
An Evaluation of the Effects of Adult Social Interaction on Infant Vocalizations
No full textThe results of previous studies suggest that infant vocalizations may be sensitive to social interaction as a reinforcer (e.g., Poulson, 1983, 1988; Rheingold, Gewirtz, & Ross, 1959). The purpose of Study 1 was to conduct descriptive analyses to examine teacher-infant interactions in three early education settings to determine (a) the prevalence of vocalizations, (b) the temporal contiguity between infant vocalizations and adult social interaction, and (c) the nature of adult social interaction. The purpose of Study 2 was to replicate the results of previous experimental analyses by demonstrating higher levels of vocalizations in a reinforcement condition as compared to levels of vocalizations in an extinction (EXT) condition. Results of Study 1 showed that (a) levels of vocalizations were similar across classrooms, (b) potential neutral contingencies between social interaction and vocalizations existed in two of the three classrooms, and (c) the nature of adult social interaction varied across the classrooms. Results of Study 2 failed to replicate those of previous research in demonstrating consistently higher levels of vocalizations in the reinforcement condition as compared to levels of vocalizations in the EXT condition. The author discusses potential reasons for this failure to replicate, including the possibility of automatically maintained vocalizations. Additional experimental analyses are necessary to further explain the inconsistent results obtained in Study 2
Clinical severity of aneurysmal subarachnoid hemorrhage over time: systematic review.
No full textThe incidence of aneurysmal subarachnoid hemorrhage (aSAH) is well studied. Yet, little is known about the trend of aSAH severity. This systematic review aims to analyze the distribution of aSAH severity over time. We performed a systematic review of the literature according to the PRISMA-P guidelines. We included studies from January 1968 up to December 2022. Studies were included if they either reported the severity of aSAH as single increments of the corresponding 5-point scale or as a binary measure (good grade 1-3, poor grade 4-5) on the Hunt and Hess (HH) or World Federation of Neurosurgical Societies (WFNS) scale. Studies with fewer than 50 patients, (systematic) reviews, and studies including non-aSAH patients were excluded. A total of 2465 publications were identified, of which 214 met the inclusion and exclusion criteria. In total, 102,845 patients with an aSAH were included. Over the last five decades the number of good-grade HH (0.741 fold, p = 0.004) and WFNS (0.749 fold, p < 0.001) has decreased. Vice versa, an increase in number of poor grade HH (2.427 fold, p = 0.004), WFNS (2.289 fold, p < 0.001), as well as HH grade 5 (6.737 fold, p = 0.010), WFNS grade 4 (1.235 fold, p = 0.008) and WFNS grade 5 (8.322 fold, p = 0.031) was observed. This systematic review shows a worldwide 2-3 fold increase of poor grade aSAH patients and an 6-8 fold increase of grade 5 patients, over the last 50 years. Whether this evolution is due to more severe hemorrhage, improvements in neuro-intensive care and prehospital management, or to a change in grading behavior is unknown. This study strongly emphasizes the necessity for an improved grading system to differentiate grade 4 and grade 5 patients for meaningful clinical decision- making
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