187 research outputs found
Category for truncated current Lie algebras
No full textIn this paper, we study an analogue of the Bernstein–Gelfand–Gelfand category O for truncated current Lie algebras gn attached to a complex semisimple Lie algebra. This category admits Verma modules and simple modules, each parametrized by the dual space of the truncated currents on a choice of Cartan subalgebra in g. Our main result describes an inductive procedure for computing composition multiplicities of simples inside Vermas for gn, in terms of similar composition multiplicities for ln−1 where l is a Levi subalgebra. As a consequence, these numbers are expressed as integral linear combinations of Kazhdan–Lusztig polynomials evaluated at 1. This generalizes recent work of the first author, where the case n=1 was treated
Human neutrophil clearance of bacterial pathogens triggers anti-microbial gamma delta T cell responses in early infection
No full textHuman blood Vc9/Vd2 T cells, monocytes and neutrophils share a responsiveness toward inflammatory chemokines and are rapidly recruited to sites of infection. Studying their interaction in vitro and relating these findings to in vivo observations in patients may therefore provide crucial insight into inflammatory events. Our present data demonstrate that Vc9/Vd2 T cells provide potent survival signals resulting in neutrophil activation and the release of the neutrophil chemoattractant CXCL8 (IL-8). In turn, Vc9/Vd2 T cells readily respond to neutrophils harboring phagocytosed bacteria, as evidenced by expression of CD69, interferon (IFN)-c and tumor necrosis factor (TNF)-a. This response is dependent on the ability of these bacteria to produce the microbial metabolite (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP), requires cell-cell contact of Vc9/Vd2 T cells with accessory monocytes through lymphocyte function-associated antigen-1 (LFA-1), and results in a TNF-a dependent proliferation of Vc9/Vd2 T cells. The antibiotic fosmidomycin, which targets the HMB-PP biosynthesis pathway, not only has a direct antibacterial effect on most HMB-PP producing bacteria but also possesses rapid anti-inflammatory properties by inhibiting cd T cell responses in vitro. Patients with acute peritoneal-dialysis (PD)-associated bacterial peritonitis – characterized by an excessive influx of neutrophils and monocytes into the peritoneal cavity – show a selective activation of local Vc9/Vd2 T cells by HMB-PP producing but not by HMB-PP deficient bacterial pathogens. The cd T celldriven perpetuation of inflammatory responses during acute peritonitis is associated with elevated peritoneal levels of cd T cells and TNF-a and detrimental clinical outcomes in infections caused by HMB-PP positive microorganisms. Taken together, our findings indicate a direct link between invading pathogens, neutrophils, monocytes and microbe-responsive cd T cells in early infection and suggest novel diagnostic and therapeutic approaches.Martin S. Davey, Chan-Yu Lin, Gareth W. Roberts, Sinéad Heuston, Amanda C. Brown, James A. Chess, Mark A. Toleman, Cormac G.M. Gahan, Colin Hill, Tanya Parish, John D. Williams, Simon J. Davies, David W. Johnson, Nicholas Topley, Bernhard Moser and Matthias Eber
Effect of freezing of milk samples on the cultural results
No full textPT: J; CR: BURROWS W, 1968, TXB MICROBIOLOGY CRUICKSHANK R, 1965, MEDICAL MICROBIOLOGY FROBISHER M, 1968, FUNDAMENTALS MICROBI KOWALSKI JJ, 1977, J AM VET MED ASSOC, V170, P1175 LEUDECKE LO, 1972, J DAIRY SCI, V55, P417 MERCHANT IA, 1967, VETERINARY BACTERIOL PELCZAR MJ, 1965, MICROBIOLOGY ROBERTS SJ, 1969, J AM VET MED ASS 1, V155, P157 WILSON GS, 1965, TOPLEY WILSONS PRINC; NR: 9; TC: 12; J9: ZBL VETERINARMED REIHE B; PG: 6; GA: GU359Source type: Electronic(1
Membrane Longevity in Peritoneal Dialysis Impact of Infection and Bio-Incompatible m Solutions
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Pathogen-specific local immune fingerprints in acute disease: towards point-of-care diagnosis of bacterial infection [Abstract]
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